"MutL Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
| Descriptor ID |
D000070956
|
| MeSH Number(s) |
D08.811.074.766 D08.811.277.040.025.215 D12.776.260.540
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "MutL Proteins".
Below are MeSH descriptors whose meaning is more specific than "MutL Proteins".
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Below are the most recent publications written about "MutL Proteins" by people in Profiles.