"Centromere Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
| Descriptor ID |
D000076247
|
| MeSH Number(s) |
D12.776.157.687.173 D12.776.260.123 D12.776.660.235.100 D12.776.660.720.173 D12.776.664.235.100 D23.050.422.031
|
| Concept/Terms |
Centromere Protein A- Centromere Protein A
- CENPA Protein
- Centromere Protein 17K
- CENP-A Protein
- CENP A Protein
- Centromere Autoantigens 17K
- Autoantigens 17K, Centromere
|
Below are MeSH descriptors whose meaning is more general than "Centromere Protein A".
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Below are the most recent publications written about "Centromere Protein A" by people in Profiles.