"MutL Protein Homolog 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
| Descriptor ID |
D000070957
|
| MeSH Number(s) |
D08.811.074.766.500 D08.811.277.040.025.215.500 D12.776.260.540.500
|
| Concept/Terms |
MutL Protein Homolog 1- MutL Protein Homolog 1
- MLH1 Protein
- Colon Cancer, Nonpolyposis Type 2 Protein
- MutL Homolog 1
- COCA2 Protein
|
Below are MeSH descriptors whose meaning is more general than "MutL Protein Homolog 1".
Below are MeSH descriptors whose meaning is more specific than "MutL Protein Homolog 1".
This graph shows the total number of publications written about "MutL Protein Homolog 1" by people in this website by year, and whether "MutL Protein Homolog 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Protein Homolog 1" by people in Profiles.
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DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility. Int J Cancer. 2020 01 15; 146(2):363-372.
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Somatic alterations, metabolizing genes and smoking in rectal cancer. Int J Cancer. 2009 Jul 01; 125(1):158-64.
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Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. Genes Chromosomes Cancer. 2009 Jan; 48(1):1-9.
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The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. Genes Chromosomes Cancer. 2008 Oct; 47(10):835-44.
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Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut. 2009 May; 58(5):661-7.
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Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology. 2005 Sep; 129(3):837-45.
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Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy. Anticancer Res. 2003 Mar-Apr; 23(2C):1773-7.
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Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry. Gastroenterology. 2002 Apr; 122(4):940-7.