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Lei Qian, PhD

TitleAssistant Investigator
InstitutionKaiser Permanente Southern California
DepartmentDepartment of Research and Evaluation
Address100 South Los Robles Avenue
Pasadena CA 91101
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    Dr. Qian is a biostatistician lead for the Division of Epidemiologic Research and the Division of Biostatistics Research. Most of Dr. Qian’s methodological research was inspired by the statistical issues seen in collaborative work, particularly in vaccine safety studies in the areas of the self-controlled study design, sequential analysis, and propensity score analysis. She is also interested in assessing the systematic intervention effects using difference-in-difference design and trends analysis with applications in vaccine, AIDS, and cardiovascular disease research. In addition, her research interests include analysis of longitudinal data, multi-level models, marginal structural models, Bayesian statistics, and survival analysis with competing risks.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qian L, Sy LS, Hong V, Glenn SC, Ryan DS, Morrissette K, Jacobsen SJ, Xu S. Disparities in Outpatient and Telehealth Visits During the COVID-19 Pandemic in a Large Integrated Health Care Organization: Retrospective Cohort Study. J Med Internet Res. 2021 09 01; 23(9):e29959. PMID: 34351865.
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    2. Mefford MT, Liu R, Bruxvoort K, Qian L, Doris JM, Koyama SY, Tseng HF, Reynolds K. Influenza vaccination and mortality among adults with heart failure in an integrated healthcare delivery system, 2009-2018. J Gen Intern Med. 2021 Aug 11. PMID: 34379280.
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    3. Bruxvoort K, Sy LS, Ackerson BK, Slezak J, Qian L, Towner W, Reynolds K, Solano Z, Carlson CM, Jacobsen SJ. Challenges in Phase 4 post-licensure safety studies using real world data in the United States: Hepatitis B vaccine example. Vaccine X. 2021 Aug; 8:100101. PMID: 34195599; PMCID: PMC8233154.
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    4. Xu S, Glenn S, Sy L, Qian L, Hong V, Ryan DS, Jacobsen S. Correction: Impact of the COVID-19 Pandemic on Health Care Utilization in a Large Integrated Health Care System: Retrospective Cohort Study. J Med Internet Res. 2021 May 05; 23(5):e30101. PMID: 33950848; PMCID: PMC8135025.
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    5. Amy Liu IL, Tanenbaum HC, Qian L, Sy LS, Chen W, Jacobsen SJ. Trends in Influenza Vaccine Uptake and Severe Influenza-Related Outcomes at Kaiser Permanente Southern California, 2007-2017. Perm J. 2021 05; 25. PMID: 33970069.
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    6. Xu S, Glenn S, Sy L, Qian L, Hong V, Ryan DS, Jacobsen S. Impact of the COVID-19 Pandemic on Health Care Utilization in a Large Integrated Health Care System: Retrospective Cohort Study. J Med Internet Res. 2021 04 29; 23(4):e26558. PMID: 33882020; PMCID: PMC8086778.
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    7. Ackerson BK, Sy LS, Glenn SC, Qian L, Park CH, Riewerts RJ, Jacobsen SJ. Pediatric Vaccination During the COVID-19 Pandemic. Pediatrics. 2021 07; 148(1). PMID: 33858983.
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    8. Ackerson B, Qian L, Sy LS, Bruxvoort K, Wu J, Luo Y, Diaz-Decaro J, Talarico C, Tseng HF. Completion of the two-dose recombinant zoster vaccine series in adults 50 years and older. Vaccine. 2021 02 05; 39(6):926-932. PMID: 33441234.
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    9. An J, Nichols GA, Qian L, Munis MA, Harrison TN, Li Z, Wei R, Weiss T, Rajpathak S, Reynolds K. Prevalence and incidence of microvascular and macrovascular complications over 15 years among patients with incident type 2 diabetes. BMJ Open Diabetes Res Care. 2021 01; 9(1). PMID: 33397671; PMCID: PMC7783518.
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    10. An J, Luong T, Qian L, Wei R, Liu R, Muntner P, Brettler J, Jaffe MG, Moran AE, Reynolds K. Treatment Patterns and Blood Pressure Control With Initiation of Combination Versus Monotherapy Antihypertensive Regimens. Hypertension. 2021 01; 77(1):103-113. PMID: 33190560.
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    11. Bruxvoort K, Slezak J, Huang R, Ackerson B, Sy LS, Qian L, Reynolds K, Towner W, Solano Z, Mercado C, Hyer R, Janssen R, Jacobsen SJ. Association of Number of Doses With Hepatitis B Vaccine Series Completion in US Adults. JAMA Netw Open. 2020 11 02; 3(11):e2027577. PMID: 33252692; PMCID: PMC7705595.
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    12. Mefford MT, Mittleman MA, Li BH, Qian LX, Reynolds K, Zhou H, Harrison TN, Geller AC, Sidney S, Sloan RP, Mostofsky E, Williams DR. Sociopolitical stress and acute cardiovascular disease hospitalizations around the 2016 presidential election. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):27054-27058. PMID: 33046627; PMCID: PMC7604431.
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    13. Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H, Li Z, Shaw SF, Caparosa SL, Nau CL, Saxena T, Rieg GK, Ackerson BK, Sharp AL, Skarbinski J, Naik TK, Murali SB. Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization. Ann Intern Med. 2020 11 17; 173(10):773-781. PMID: 32783686; PMCID: PMC7429998.
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    14. Tartof SY, Chen LH, Tian Y, Wei R, Im T, Yu K, Rieg G, Bider-Canfield Z, Wong F, Takhar HS, Qian L. Do Inpatient Antimicrobial Stewardship Programs help us in the Battle against Antimicrobial Resistance? Clin Infect Dis. 2020 Jul 15. PMID: 32667983.
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    15. Bruxvoort KJ, Bider-Canfield Z, Casey JA, Qian L, Pressman A, Liang AS, Robinson S, Jacobsen SJ, Tartof SY. Outpatient Urinary Tract Infections in an Era of Virtual Healthcare: Trends From 2008 to 2017. Clin Infect Dis. 2020 06 24; 71(1):100-108. PMID: 31437269; PMCID: PMC7456352.
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    16. An J, Nichols GA, Qian L, Harrison TN, Li Z, Munis MA, Wei R, Weiss T, Rajpathak S, Reynolds K. Time in suboptimal glycemic control over 10?years for patients newly diagnosed with type 2 diabetes. J Diabetes Complications. 2020 08; 34(8):107607. PMID: 32499115.
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    17. Mefford MT, Li BH, Qian L, Reading SR, Harrison TN, Scott RD, Cavendish JJ, Jacobsen SJ, Kanter MH, Woodward M, Reynolds K. Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014. Circulation. 2020 02 18; 141(7):509-519. PMID: 32065770.
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    18. Yu W, Zheng C, Xie F, Chen W, Mercado C, Sy LS, Qian L, Glenn S, Tseng HF, Lee G, Duffy J, McNeil MM, Daley MF, Crane B, McLean HQ, Jackson LA, Jacobsen SJ. The use of natural language processing to identify vaccine-related anaphylaxis at five health care systems in the Vaccine Safety Datalink. Pharmacoepidemiol Drug Saf. 2020 02; 29(2):182-188. PMID: 31797475; PMCID: PMC7528887.
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    19. Reynolds K, Mues KE, Harrison TN, Qian L, Chen S, Hsu JY, Philip KJ, Monda KL, Reading SR, Brar SS. Trends in statin utilization among adults with severe peripheral artery disease including critical limb ischemia in an integrated healthcare delivery system. Vasc Med. 2020 02; 25(1):3-12. PMID: 31512991.
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    20. Bruxvoort KJ, Liang AS, Harpaz R, Qian L, Sy LS, LaRussa P, Schmid DS, Luo Y, Takhar H, Tseng HF. Patient report of herpes zoster pain: Incremental benefits of zoster vaccine live. Vaccine. 2019 06 06; 37(26):3478-3484. PMID: 31088744; PMCID: PMC6548453.
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    21. Hechter RC, Qian L, Tartof SY, Sy LS, Klein NP, Weintraub E, Mercado C, Naleway A, McLean HQ, Jacobsen SJ. Vaccine safety in HIV-infected adults within the Vaccine Safety Datalink Project. Vaccine. 2019 05 31; 37(25):3296-3302. PMID: 31064675; PMCID: PMC6538462.
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    22. Zheng C, Yu W, Xie F, Chen W, Mercado C, Sy LS, Qian L, Glenn S, Lee G, Tseng HF, Duffy J, Jackson LA, Daley MF, Crane B, McLean HQ, Jacobsen SJ. The use of natural language processing to identify Tdap-related local reactions at five health care systems in the Vaccine Safety Datalink. Int J Med Inform. 2019 07; 127:27-34. PMID: 31128829; PMCID: PMC6645678.
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    23. Tartof SY, Qian L, Liu IA, Tseng HF, Sy LS, Hechter RC, Lewin BJ, Jacobsen SJ. Safety of Influenza Vaccination Administered During Hospitalization. Mayo Clin Proc. 2019 Mar; 94(3):397-407. PMID: 30635116.
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    24. Gervacio GB, Sidell M, Li X, Young DR, Batech M, Qian L, Reynolds K, Koebnick C. Health Status of Young Adults with Insurance Coverage Before and After Affordable Care Act Passage. Perm J. 2019; 23. PMID: 30939274.
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    25. Tartof SY, Hsu JW, Wei R, Rubenstein KB, Hu H, Arduino JM, Horberg M, Derose SF, Qian L, Rodriguez CV. Kidney Function Decline in Patients with CKD and Untreated Hepatitis C Infection. Clin J Am Soc Nephrol. 2018 Oct 08; 13(10):1471-1478. PMID: 30242027.
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    26. Hechter RC, Qian L, Luo Y, Ling Grant DS, Baxter R, Klein NP, Valdez Nunley K, Aukes L, Hogea C, Krishnarajah G, Patterson BJ, Im TM, Tseng HF. Impact of an electronic medical record reminder on hepatitis B vaccine initiation and completion rates among insured adults with diabetes mellitus. Vaccine. 2019 Jan 03; 37(1):195-201. PMID: 29958736.
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    27. Chen W, Qian L, Shi J, Franklin M. Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification. BMC Med Res Methodol. 2018 06 22; 18(1):63. PMID: 29929477.
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    28. Tseng HF, Sy LS, Qian L, Liu IA, Mercado C, Lewin B, Tartof SY, Nelson J, Jackson LA, Daley MF, Weintraub E, Klein NP, Belongia E, Liles EG, Jacobsen SJ. Pneumococcal Conjugate Vaccine Safety in Elderly Adults. Open Forum Infect Dis. 2018 Jun; 5(6):ofy100. PMID: 29977960.
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    29. Zerbo O, Modaressi S, Goddard K, Lewis E, Fireman BH, Daley MF, Irving SA, Jackson LA, Donahue JG, Qian L, Getahun D, DeStefano F, McNeil MM, Klein NP. Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings. JAMA Pediatr. 2018 May 01; 172(5):469-475. PMID: 29582071.
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    30. Hechter RC, Qian L, Yan S, Luo Y, Krishnarajah G, Tseng HF. Impact of the change of copay policy in Medicare Part D on zoster vaccine uptake among Medicare beneficiaries in a managed care organization. BMC Health Serv Res. 2017 07 21; 17(1):503. PMID: 28732518.
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    31. Zeiger RS, Schatz M, Dalal AA, Chen W, Sadikova E, Suruki RY, Kawatkar AA, Qian L. Blood Eosinophil Count and Outcomes in Severe Uncontrolled Asthma: A Prospective Study. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):144-153.e8. PMID: 27665383.
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    32. Vazquez-Benitez G, Kharbanda EO, Naleway AL, Lipkind H, Sukumaran L, McCarthy NL, Omer SB, Qian L, Xu S, Jackson ML, Vijayadev V, Klein NP, Nordin JD. Risk of Preterm or Small-for-Gestational-Age Birth After Influenza Vaccination During Pregnancy: Caveats When Conducting Retrospective Observational Studies. Am J Epidemiol. 2016 08 01; 184(3):176-86. PMID: 27449414.
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    33. Tartof SY, Qian L, Rieg GK, Yu KC, Sy LS, Tseng HF, Hechter RC, Jacobsen SJ. Safety of Seasonal Influenza Vaccination in Hospitalized Surgical Patients: A Cohort Study. Ann Intern Med. 2016 05 03; 164(9):593-9. PMID: 26974053.
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    34. Zeiger RS, Schatz M, Dalal AA, Qian L, Chen W, Ngor EW, Suruki RY, Kawatkar AA. Utilization and Costs of Severe Uncontrolled Asthma in a Managed-Care Setting. J Allergy Clin Immunol Pract. 2016 Jan-Feb; 4(1):120-9.e3. PMID: 26439182.
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    35. Langer-Gould A, Qian L, Tartof SY, Brara SM, Jacobsen SJ, Beaber BE, Sy LS, Chao C, Hechter R, Tseng HF. Vaccines and the risk of multiple sclerosis and other central nervous system demyelinating diseases. JAMA Neurol. 2014 Dec; 71(12):1506-13. PMID: 25329096.
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    36. Tartof SY, Tseng HF, Liu IL, Qian L, Sy LS, Hechter RC, Marcy SM, Jacobsen SJ. Inpatient admission for febrile seizure and subsequent outcomes do not differ in children with vaccine-associated versus non-vaccine associated febrile seizures. Vaccine. 2014 Nov 12; 32(48):6408-14. PMID: 25285882.
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    37. Chen W, Shi J, Qian L, Azen SP. Comparison of robustness to outliers between robust poisson models and log-binomial models when estimating relative risks for common binary outcomes: a simulation study. BMC Med Res Methodol. 2014 Jun 26; 14:82. PMID: 24965498.
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    38. Tartof SY, Tseng HF, Liu AL, Qian L, Sy LS, Hechter RC, Marcy SM, Jacobsen SJ. Exploring the risk factors for vaccine-associated and non-vaccine associated febrile seizures in a large pediatric cohort. Vaccine. 2014 May 07; 32(22):2574-81. PMID: 24674662.
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    39. Xu S, Newcomer S, Nelson J, Qian L, McClure D, Pan Y, Zeng C, Glanz J. Signal detection of adverse events with imperfect confirmation rates in vaccine safety studies using self-controlled case series design. Biom J. 2014 May; 56(3):513-25. PMID: 24402780.
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    40. Tseng HF, Sy LS, Liu IL, Qian L, Marcy SM, Weintraub E, Yih K, Baxter R, Glanz JM, Donahue J, Naleway A, Nordin J, Jacobsen SJ. Postlicensure surveillance for pre-specified adverse events following the 13-valent pneumococcal conjugate vaccine in children. Vaccine. 2013 May 24; 31(22):2578-83. PMID: 23579258.
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    41. Hechter RC, Qian L, Sy LS, Greene SK, Weintraub ES, Naleway AL, Rowhani-Rahbar A, Donahue JG, Daley MF, Vazquez-Benitez G, Lugg MM, Jacobsen SJ. Secular trends in diagnostic code density in electronic healthcare data from health care systems in the Vaccine Safety Datalink project. Vaccine. 2013 Feb 04; 31(7):1080-5. PMID: 23267842.
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    42. Tseng HF, Sy LS, Qian L, Marcy SM, Jackson LA, Glanz J, Nordin J, Baxter R, Naleway A, Donahue J, Weintraub E, Jacobsen SJ. Safety of a tetanus-diphtheria-acellular pertussis vaccine when used off-label in an elderly population. Clin Infect Dis. 2013 Feb; 56(3):315-21. PMID: 23196953.
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    43. Qian L, Tseng HF, Sy LS, Jacobsen SJ. Confounder adjustment in vaccine safety studies: comparing three offset terms for case-centered approach. Vaccine. 2013 Jan 02; 31(2):431-5. PMID: 22871350.
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