"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
|
| MeSH Number(s) |
A03.734.414 A06.407.414
|
| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
|
Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024 Mar; 627(8003):347-357.
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Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic ß-Cell Dysfunction. Diabetes. 2018 05; 67(5):885-897.
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Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet. 2016 Jul 07; 99(1):56-75.
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Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Ther. 2015 Nov; 22(11):876-82.
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Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol Genet Metab. 2010 May; 100(1):77-82.
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Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes. Diabetes. 2006 Apr; 55(4):1074-9.
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Gestational diabetes mellitus. J Clin Invest. 2005 Mar; 115(3):485-91.
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Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes: impact on glucose tolerance and beta-cell function. J Clin Endocrinol Metab. 2004 Jun; 89(6):2846-51.
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Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes. 2002 Sep; 51(9):2796-803.
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Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. Diabetes. 2000 May; 49(5):782-8.