"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study. J Am Geriatr Soc. 2017 Dec; 65(12):2627-2633.
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Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. Alzheimers Dement. 2017 Dec; 13(12):1307-1316.
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Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathol. 2017 05; 133(5):839-856.
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Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease. Alzheimers Dement. 2017 Aug; 13(8):933-939.
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Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis. 2017; 59(4):1307-1315.
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Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2017 02; 13(2):119-129.
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Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes. Neurobiol Aging. 2015 Oct; 36(10):2702-8.
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Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement. 2016 Mar; 12(3):233-43.
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Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord. 2014 Jan-Mar; 28(1):36-43.
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Glucose levels and risk of dementia. N Engl J Med. 2013 Aug 08; 369(6):540-8.