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Willa D. Brenowitz, PhD, MPH

TitleInvestigator
InstitutionKaiser Permanente Northwest
DepartmentCenter for Health Research
Address3800 N. Interstate Avenue
Portland OR 97227
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD. Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia. JAMA Netw Open. 2024 Jul 01; 7(7):e2424539. PMID: 39078629; PMCID: PMC11289698.
      Citations:    
    2. Gao Y, Andrews S, Daghlas I, Brenowitz WD, Raji CA, Yaffe K, Leng Y. Snoring and risk of dementia: a prospective cohort and Mendelian randomization study. Sleep. 2024 Jun 29. PMID: 38943476.
      Citations:    
    3. Andrews SJ, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K, Alzheimer?s Disease Neuroimaging Initiative. Modifiable risk factors, APOE and risk of Alzheimer disease: one size does not fit all. medRxiv. 2024 Apr 29. PMID: 38746455; PMCID: PMC11092714.
      Citations:    
    4. Buto PT, Wang J, La Joie R, Zimmerman SC, Glymour MM, Ackley SF, Hoffmann TJ, Yaffe K, Zeki Al Hazzouri A, Brenowitz WD. Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK biobank participants. Alzheimers Dement. 2024 Jan 06. PMID: 38183377.
      Citations:    
    5. Qian H, Khadka A, Martinez SM, Singh S, Brenowitz WD, Zeki Al Hazzouri A, Hill-Jarrett TG, Glymour MM, Vable AM. Food Insecurity, Memory, and Dementia Among US Adults Aged 50 Years and Older. JAMA Netw Open. 2023 Nov 01; 6(11):e2344186. PMID: 37988079; PMCID: PMC10663972.
      Citations:    
    6. Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y. Snoring and risk of dementia: a prospective cohort and Mendelian randomization study. medRxiv. 2023 Oct 13. PMID: 37873444; PMCID: PMC10593011.
      Citations:    
    7. Kamath V, Jiang K, Manning KJ, Mackin RS, Walker KA, Powell D, Lin FR, Chen H, Brenowitz WD, Yaffe K, Simonsick EM, Deal JA. Olfactory Dysfunction and Depression Trajectories in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2023 Jun 26. PMID: 37357824.
      Citations:    Fields:    
    8. Ospina-Romero M, Brenowitz WD, Glymour MM, Westrick A, Graff RE, Hayes-Larson E, Mayeda ER, Ackley SF, Kobayashi LC. Education, incident cancer, and rate of memory decline in a national sample of US adults in mid-to-later-life. J Geriatr Oncol. 2023 06; 14(5):101530. PMID: 37210786; PMCID: PMC10332197.
      Citations:    Fields:    Translation:Humans
    9. Brenowitz WD, Fornage M, Launer LJ, Habes M, Davatzikos C, Yaffe K. Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife. Ann Neurol. 2023 Mar; 93(3):629-634. PMID: 36511390.
      Citations:    Fields:    Translation:Humans
    10. Brenowitz WD, Yaffe K. Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials. Nat Rev Neurol. 2022 Dec; 18(12):747-757. PMID: 36316487; PMCID: PMC9894623.
      Citations:    Fields:    Translation:Humans
    11. Armstrong NM, Vieira Ligo Teixeira C, Gendron C, Brenowitz WD, Lin FR, Swenor B, Powell DS, Deal JA, Simonsick EM, Jones RN. Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States. J Affect Disord. 2022 11 15; 317:114-122. PMID: 35932940.
      Citations:    Fields:    Translation:Humans
    12. Duchowny KA, Ackley SF, Brenowitz WD, Wang J, Zimmerman SC, Caunca MR, Glymour MM. Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study. JAMA Netw Open. 2022 06 01; 5(6):e2218314. PMID: 35737388; PMCID: PMC9227006.
      Citations: 10     Fields:    Translation:Humans
    13. Powell DS, Brenowitz WD, Yaffe K, Armstrong NM, Reed NS, Lin FR, Gross AL, Deal JA. Examining the Combined Estimated Effects of Hearing Loss and Depressive Symptoms on Risk of Cognitive Decline and Incident Dementia. J Gerontol B Psychol Sci Soc Sci. 2022 05 05; 77(5):839-849. PMID: 34655295; PMCID: PMC9071460.
      Citations: 3     Fields:    Translation:Humans
    14. Zimmerman SC, Brenowitz WD, Calmasini C, Ackley SF, Graff RE, Asiimwe SB, Staffaroni AM, Hoffmann TJ, Glymour MM. Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife. JAMA Netw Open. 2022 04 01; 5(4):e225491. PMID: 35377426; PMCID: PMC8980909.
      Citations: 3     Fields:    Translation:Humans
    15. Armstrong NM, Vieira Ligo Teixeira C, Gendron C, Brenowitz WD, Lin FR, Swenor B, Deal JA, Simonsick EM, Jones RN. Associations of dual sensory impairment with incident mobility and ADL difficulty. J Am Geriatr Soc. 2022 07; 70(7):1997-2007. PMID: 35343588; PMCID: PMC9283239.
      Citations: 2     Fields:    Translation:Humans
    16. Brenowitz WD, Robbins NM, Strotmeyer ES, Yaffe K. Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults. Neurology. 2022 05 03; 98(18):e1837-e1845. PMID: 35264428; PMCID: PMC9109146.
      Citations: 4     Fields:    Translation:Humans
    17. Brenowitz WD. Invited Commentary: Body Mass Index and Risk of Dementia-Potential Explanations for Life-Course Differences in Risk Estimates and Future Research Directions. Am J Epidemiol. 2021 12 01; 190(12):2511-2514. PMID: 33831175; PMCID: PMC8796800.
      Citations: 1     Fields:    Translation:Humans
    18. Le JT, Agr?n E, Keenan TDL, Clemons TE, Brenowitz WD, Yaffe K, Chew EY, AREDS2 Research Group. Assessing bidirectional associations between cognitive impairment and late age-related macular degeneration in the Age-Related Eye Disease Study 2. Alzheimers Dement. 2022 07; 18(7):1296-1305. PMID: 34758100; PMCID: PMC9085971.
      Citations: 1     Fields:    Translation:Humans
    19. Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. Current Alzheimer disease research highlights: evidence for novel risk factors. Chin Med J (Engl). 2021 Sep 09; 134(18):2150-2159. PMID: 34507318; PMCID: PMC8478399.
      Citations: 5     Fields:    Translation:Humans
    20. Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC. The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship. Alzheimer Dis Assoc Disord. 2021 Jul-Sep 01; 35(3):271-274. PMID: 32568784; PMCID: PMC7749066.
      Citations: 1     Fields:    Translation:Humans
    21. Besser LM, Brenowitz WD, Meyer OL, Hoermann S, Renne J. Methods to Address Self-Selection and Reverse Causation in Studies of Neighborhood Environments and Brain Health. Int J Environ Res Public Health. 2021 06 16; 18(12). PMID: 34208454; PMCID: PMC8296350.
      Citations: 8     Fields:    Translation:Humans
    22. Ackley SF, Hayes-Larson E, Brenowitz WD, Swinnerton K, Mungas D, Fletcher E, Singh B, Whitmer RA, DeCarli C, Maria Glymour M. Amyloid-PET imaging offers small improvements in predictions of future cognitive trajectories. Neuroimage Clin. 2021; 31:102713. PMID: 34153689; PMCID: PMC8233225.
      Citations: 2     Fields:    Translation:Humans
    23. Brenowitz WD, Wallhagen MI. Does Hearing Impairment Affect Physical Function?: Current Evidence, Potential Mechanisms, and Future Research Directions for Healthy Aging. JAMA Netw Open. 2021 06 01; 4(6):e2114782. PMID: 34170308.
      Citations: 1     Fields:    Translation:Humans
    24. Brenowitz WD, Zimmerman SC, Filshtein TJ, Yaffe K, Walter S, Hoffmann TJ, Jorgenson E, Whitmer RA, Glymour MM. Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer's Disease: Genetic Risk Score for Alzheimer's Disease Reduces BMI by Age 50. Am J Epidemiol. 2021 Apr 12. PMID: 33843952.
      Citations: 6     Fields:    Translation:Humans
    25. Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O'Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Na?l V, Narasimhalu K, Chen CLH, Lamoureux EL. The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis. Ophthalmology. 2021 07; 128(7):981-992. PMID: 33333104.
      Citations: 19     Fields:    Translation:HumansPHPublic Health
    26. Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER, Filshtein TJ, Power MC, Elahi FM, Brickman AM, Glymour MM. Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis. BMJ. 2021 02 25; 372:n156. PMID: 33632704; PMCID: PMC7905687.
      Citations: 47     Fields:    Translation:Humans
    27. Brenowitz WD, Zeki Al Hazzouri A, Vittinghoff E, Golden SH, Fitzpatrick AL, Yaffe K. Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline. J Alzheimers Dis. 2021; 83(3):1379-1389. PMID: 34420969; PMCID: PMC9095065.
      Citations: 7     Fields:    Translation:Humans
    28. Ospina-Romero M, Glymour MM, Hayes-Larson E, Mayeda ER, Graff RE, Brenowitz WD, Ackley SF, Witte JS, Kobayashi LC. Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020 11 02; 3(11):e2025515. PMID: 33185677; PMCID: PMC7666424.
      Citations: 24     Fields:    Translation:Humans
    29. Bock MA, Bahorik A, Brenowitz WD, Yaffe K. Apathy and risk of probable incident dementia among community-dwelling older adults. Neurology. 2020 12 15; 95(24):e3280-e3287. PMID: 33055276; PMCID: PMC7836653.
      Citations: 9     Fields:    Translation:Humans
    30. Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD. Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders. Ann Neurol. 2021 01; 89(1):177-181. PMID: 32951248; PMCID: PMC8048405.
      Citations: 15     Fields:    Translation:Humans
    31. Brenowitz WD, Filshtein TJ, Yaffe K, Walter S, Ackley SF, Hoffmann TJ, Jorgenson E, Whitmer RA, Glymour MM. Association of genetic risk for Alzheimer disease and hearing impairment. Neurology. 2020 10 20; 95(16):e2225-e2234. PMID: 32878991; PMCID: PMC7713783.
      Citations: 10     Fields:    Translation:Humans
    32. Brenowitz WD, Besser LM, Kukull WA, Keene CD, Glymour MM, Yaffe K. Clinician-judged hearing impairment and associations with neuropathologic burden. Neurology. 2020 09 22; 95(12):e1640-e1649. PMID: 32759190; PMCID: PMC7713726.
      Citations: 5     Fields:    Translation:HumansCells
    33. Brenowitz WD, Kaup AR, Yaffe K. Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores. Alzheimers Dement. 2020 10; 16(10):1384-1392. PMID: 32657033; PMCID: PMC7901640.
      Citations: 4     Fields:    Translation:Humans
    34. Hwang PH, Longstreth WT, Brenowitz WD, Thielke SM, Lopez OL, Francis CE, DeKosky ST, Fitzpatrick AL. Dual sensory impairment in older adults and risk of dementia from the GEM Study. Alzheimers Dement (Amst). 2020; 12(1):e12054. PMID: 32671180; PMCID: PMC7340796.
      Citations: 15     
    35. Edwards RD, Brenowitz WD, Portacolone E, Covinsky KE, Bindman A, Glymour MM, Torres JM. Difficulty and help with activities of daily living among older adults living alone with cognitive impairment. Alzheimers Dement. 2020 08; 16(8):1125-1133. PMID: 32588985; PMCID: PMC7416441.
      Citations: 13     Fields:    Translation:Humans
    36. Brenowitz WD, Manly JJ, Murchland AR, Nguyen TT, Liu SY, Glymour MM, Levine DA, Crowe M, Hohman TJ, Dufouil C, Launer LJ, Hedden T, Eng CW, Wadley VG, Howard VJ. State School Policies as Predictors of Physical and Mental Health: A Natural Experiment in the REGARDS Cohort. Am J Epidemiol. 2020 05 05; 189(5):384-393. PMID: 31595946; PMCID: PMC7306678.
      Citations: 4     Fields:    Translation:Humans
    37. Gauthreaux K, Bonnett TA, Besser LM, Brenowitz WD, Teylan M, Mock C, Chen YC, Chan KCG, Keene CD, Zhou XH, Kukull WA. Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy. J Neuropathol Exp Neurol. 2020 05 01; 79(5):465-473. PMID: 32186726; PMCID: PMC7160616.
      Citations: 8     Fields:    Translation:Humans
    38. Besser LM, Brenowitz WD, Park J, Tolea MI, Galvin JE. Intention to Screen for Alzheimer's Disease by Residential Locale. Int J Environ Res Public Health. 2020 03 27; 17(7). PMID: 32230914; PMCID: PMC7178144.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    39. Han F, Bonnett T, Brenowitz WD, Teylan MA, Besser LM, Chen YC, Chan G, Cao KG, Gao Y, Zhou XH. Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression. PLoS One. 2020; 15(1):e0227924. PMID: 31951629; PMCID: PMC6968868.
      Citations: 2     Fields:    Translation:Humans
    40. Zahodne LB, Sharifian N, Manly JJ, Sumner JA, Crowe M, Wadley VG, Howard VJ, Murchland AR, Brenowitz WD, Weuve J. Life course biopsychosocial effects of retrospective childhood social support and later-life cognition. Psychol Aging. 2019 Nov; 34(7):867-883. PMID: 31566397; PMCID: PMC6829036.
      Citations: 6     Fields:    Translation:Humans
    41. Filshtein TJ, Brenowitz WD, Mayeda ER, Hohman TJ, Walter S, Jones RN, Elahi FM, Glymour MM. Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality. Alzheimers Dement. 2019 07; 15(7):907-916. PMID: 31327391; PMCID: PMC7049165.
      Citations: 8     Fields:    Translation:Humans
    42. Ospina-Romero M, Abdiwahab E, Kobayashi L, Filshtein T, Brenowitz WD, Mayeda ER, Glymour MM. Rate of Memory Change Before and After Cancer Diagnosis. JAMA Netw Open. 2019 06 05; 2(6):e196160. PMID: 31225893; PMCID: PMC6593639.
      Citations: 24     Fields:    Translation:Humans
    43. Brenowitz WD, Kaup AR, Lin FR, Yaffe K. Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults. J Gerontol A Biol Sci Med Sci. 2019 05 16; 74(6):890-896. PMID: 30452551; PMCID: PMC6521912.
      Citations: 40     Fields:    Translation:Humans
    44. Brenowitz WD, Han F, Kukull WA, Nelson PT. Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging. 2018 02; 62:64-71. PMID: 29107848; PMCID: PMC5743774.
      Citations: 13     Fields:    Translation:HumansCells
    45. Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. Mixed neuropathologies and associations with domain-specific cognitive decline. Neurology. 2017 Oct 24; 89(17):1773-1781. PMID: 28939667; PMCID: PMC5664309.
      Citations: 11     Fields:    Translation:Humans
    46. Brenowitz WD, Keene CD, Hawes SE, Hubbard RA, Longstreth WT, Woltjer RL, Crane PK, Larson EB, Kukull WA. Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging. 2017 May; 53:83-92. PMID: 28236716.
      Citations: 29     Fields:    Translation:Humans
    47. Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement. 2017 Jun; 13(6):654-662. PMID: 27870939; PMCID: PMC5438283.
      Citations: 36     Fields:    Translation:Humans
    48. Brenowitz WD, Nelson PT, Besser LM, Heller KB, Kukull WA. Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes. Neurobiol Aging. 2015 Oct; 36(10):2702-8. PMID: 26239176; PMCID: PMC4562901.
      Citations: 47     Fields:    Translation:Humans
    49. Brenowitz WD, Hubbard RA, Crane PK, Gray SL, Zaslavsky O, Larson EB. Longitudinal associations between self-rated health and performance-based physical function in a population-based cohort of older adults. PLoS One. 2014; 9(11):e111761. PMID: 25365288.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    50. Brenowitz WD, Kukull WA, Beresford SA, Monsell SE, Williams EC. Social relationships and risk of incident mild cognitive impairment in U.S. Alzheimer's disease centers. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):253-60. PMID: 24577205; PMCID: PMC4139444.
      Citations: 8     Fields:    Translation:Humans
    51. Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT. Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration. J Alzheimers Dis. 2014; 39(3):691-702. PMID: 24270205; PMCID: PMC3946156.
      Citations: 55     Fields:    Translation:HumansCells
    52. Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus DH, Kukull W, Gustafson DR. Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord. 2014 Jan-Mar; 28(1):36-43. PMID: 24126214; PMCID: PMC3945175.
      Citations: 68     Fields:    Translation:Humans
    53. Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT. Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain. 2014 Jan; 137(Pt 1):255-67. PMID: 24271328; PMCID: PMC3891448.
      Citations: 68     Fields:    Translation:Humans
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