"KRIT1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.
| Descriptor ID |
D000075927
|
| MeSH Number(s) |
D12.776.220.600.450.458 D12.776.624.664.700.119 D12.776.631.560.465
|
| Concept/Terms |
KRIT1 Protein- KRIT1 Protein
- Krev Interaction Trapped Protein 1
- Cerebral Cavernous Malformations 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "KRIT1 Protein".
Below are MeSH descriptors whose meaning is more specific than "KRIT1 Protein".
This graph shows the total number of publications written about "KRIT1 Protein" by people in this website by year, and whether "KRIT1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "KRIT1 Protein" by people in Profiles.
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Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radic Biol Med. 2016 Mar; 92:100-109.
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Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity. Cerebrovasc Dis. 2014; 38(6):433-40.
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Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation. Cerebrovasc Dis. 2014; 37(1):57-63.