"Spastin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.
| Descriptor ID |
D000074181
|
| MeSH Number(s) |
D08.811.277.040.013.500.500 D08.811.277.040.025.024.500 D12.776.157.025.750.500 D12.776.220.600.450.465 D12.776.631.560.480
|
| Concept/Terms |
Spastin- Spastin
- Spastic Paraplegia 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Spastin".
Below are MeSH descriptors whose meaning is more specific than "Spastin".
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Below are the most recent publications written about "Spastin" by people in Profiles.