"Thyroid Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
| Descriptor ID |
D000074482
|
| MeSH Number(s) |
D12.776.260.400.871 D12.776.660.823 D12.776.930.888
|
| Concept/Terms |
Thyroid Nuclear Factor 1- Thyroid Nuclear Factor 1
- Thyroid Transcription Factor 1
- TITF-1 Protein
- TITF 1 Protein
- Homeobox Protein Nkx-2.1
- Homeobox Protein Nkx 2.1
- Nkx-2.1, Homeobox Protein
- NK2 Homeobox 1 Protein
- TITF1 Protein
- TTF-1 Thyroid Nuclear Factor
- TTF 1 Thyroid Nuclear Factor
- Thyroid-Specific Enhancer-Binding Protein
- Enhancer-Binding Protein, Thyroid-Specific
- Thyroid Specific Enhancer Binding Protein
|
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