"Thrombospondins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
| Descriptor ID |
D019699
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| MeSH Number(s) |
D12.776.395.550.895 D12.776.543.550.895
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thrombospondins".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondins".
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Below are the most recent publications written about "Thrombospondins" by people in Profiles.