A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984)

Descriptor ID	D007625
MeSH Number(s)	C05.651.460.700.500 C10.292.562.750.250.500 C10.597.622.447.511.500 C10.668.491.500.700.500 C11.590.472.250.500 C11.768.585.658.500.627 C14.280.238.510 C18.452.660.410 C18.452.660.560.700.500 C23.888.592.636.447.511.500
Concept/Terms	Kearns-Sayre Syndrome Kearns-Sayre Syndrome Syndrome, Kearns-Sayre CPEO with Myopathy CPEO with Myopathies Myopathies, CPEO with Myopathy, CPEO with CPEO with Ragged Red Fibers Cpeo With Ragged-Red Fibers Kearn-Sayre Mitochondrial Cytopathy Cytopathy, Kearn-Sayre Mitochondrial Kearn Sayre Mitochondrial Cytopathy Mitochondrial Cytopathy, Kearn-Sayre Kearns Sayre Syndrome Sayre Syndrome, Kearns Syndrome, Kearns Sayre Kearns Syndrome Syndrome, Kearns Kearns' Syndrome Kearn Syndrome Syndrome, Kearns' Kearns-Sayre-Shy-Daroff Syndrome Kearns Sayre Shy Daroff Syndrome Syndrome, Kearns-Sayre-Shy-Daroff Oculocraniosomatic Syndrome Oculocraniosomatic Syndromes Syndrome, Oculocraniosomatic Ophthalmoplegia Plus Syndrome Ophthalmoplegia Plus Syndromes Syndrome, Ophthalmoplegia Plus Ophthalmoplegia, Pigmentary Degeneration of Retina, and Cardiomyopathy Ophthalmoplegia, Progressive External, With Ragged-Red Fibers Ophthalmoplegia-Plus Syndrome Kearns-Sayre Mitochondrial Cytopathy Chronic Progressive External Ophthalmoplegia with Myopathy

Below are MeSH descriptors whose meaning is more general than "Kearns-Sayre Syndrome".

Below are MeSH descriptors whose meaning is related to "Kearns-Sayre Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Kearns-Sayre Syndrome".