Hypoxanthine Phosphoribosyltransferase
"Hypoxanthine Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
| Descriptor ID |
D007041
|
| MeSH Number(s) |
D08.811.913.400.725.450
|
| Concept/Terms |
Hypoxanthine Phosphoribosyltransferase- Hypoxanthine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine
- IMP Pyrophosphorylase
- Pyrophosphorylase, IMP
- HGPRT
- HPRT
- HPRTase
- Hypoxanthine-Guanine Phosphoribosyltransferase
- Hypoxanthine Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine-Guanine
- Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Guanine
|
Below are MeSH descriptors whose meaning is more general than "Hypoxanthine Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Hypoxanthine Phosphoribosyltransferase".
This graph shows the total number of publications written about "Hypoxanthine Phosphoribosyltransferase" by people in this website by year, and whether "Hypoxanthine Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hypoxanthine Phosphoribosyltransferase" by people in Profiles.
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hprt mutant frequencies, nonpulmonary malignancies, and domestic radon exposure: "postmortem" analysis of an interesting hypothesis. Environ Mol Mutagen. 2001; 37(1):7-16.