A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)

Descriptor ID	D006211
MeSH Number(s)	C10.228.140.079.800 C10.228.140.744.320 C10.228.662.575 C10.574.500.700 C16.320.400.650
Concept/Terms	Pantothenate Kinase-Associated Neurodegeneration Pantothenate Kinase-Associated Neurodegeneration Neurodegeneration, Pantothenate Kinase-Associated Pantothenate Kinase Associated Neurodegeneration Hallervorden-Spatz Syndrome Hallervorden Spatz Syndrome Neurodegeneration With Brain Iron Accumulation 1 Neurodegeneration with Brain Iron Accumulation Type 1 Pigmentary Pallidal Degeneration Degeneration, Pigmentary Pallidal PKAN Neuroaxonal Dystrophy, Juvenile-Onset PKAN Neuroaxonal Dystrophy, Juvenile Onset Neuroaxonal Dystrophy, Juvenile-Onset Dystrophies, Juvenile-Onset Neuroaxonal Dystrophy, Juvenile-Onset Neuroaxonal Juvenile-Onset Neuroaxonal Dystrophies Juvenile-Onset Neuroaxonal Dystrophy Neuroaxonal Dystrophies, Juvenile-Onset Neuroaxonal Dystrophy, Juvenile Onset Hallervorden-Spatz Disease Hallervorden Spatz Disease Pigmentary Pallidal Atrophy Pallidal Atrophy, Pigmentary

Below are MeSH descriptors whose meaning is more general than "Pantothenate Kinase-Associated Neurodegeneration".

Below are MeSH descriptors whose meaning is related to "Pantothenate Kinase-Associated Neurodegeneration".

Below are MeSH descriptors whose meaning is more specific than "Pantothenate Kinase-Associated Neurodegeneration".