"X-linked Nuclear Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
| Descriptor ID |
D000075924
|
| MeSH Number(s) |
D08.811.399.340.375
|
| Concept/Terms |
X-linked Nuclear Protein- X-linked Nuclear Protein
- Nuclear Protein, X-linked
- X linked Nuclear Protein
- RAD54 Homolog Protein
- Homolog Protein, RAD54
- ATRX Protein
|
Below are MeSH descriptors whose meaning is more general than "X-linked Nuclear Protein".
Below are MeSH descriptors whose meaning is more specific than "X-linked Nuclear Protein".
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