Discs Large Homolog 1 Protein
"Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.
| Descriptor ID |
D000074288
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| MeSH Number(s) |
D08.811.913.696.650.450.500 D12.644.360.024.287 D12.776.157.057.023 D12.776.476.024.325 D12.776.543.213
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| Concept/Terms |
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