"ADAM17 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
| Descriptor ID |
D000072198
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.375 D09.400.430.500.375 D12.776.395.033.375
|
| Concept/Terms |
ADAM17 Protein- ADAM17 Protein
- TACE (Enzyme)
- TNF-alpha Converting Enzyme
- TNF alpha Converting Enzyme
- Tumor Necrosis Factor Alpha Convertase
- ADAM-17
- Tumor Necrosis Factor-alpha Converting Enzyme
- Tumor Necrosis Factor alpha Converting Enzyme
- TNF-alpha Convertase
- Convertase, TNF-alpha
- TNF alpha Convertase
- CD156b Antigen
- Antigen, CD156b
- ADAM-17 Protein
- ADAM 17 Protein
- Disintegrin and Metalloproteinase Domain-Containing Protein 17
- Disintegrin and Metalloproteinase Domain Containing Protein 17
- TACA (Enzyme)
- Tumor Necrosis Factor-alpha Convertase
|
Below are MeSH descriptors whose meaning is more general than "ADAM17 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM17 Protein".
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Below are the most recent publications written about "ADAM17 Protein" by people in Profiles.