One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

Descriptor ID	D000071636
MeSH Number(s)	D08.811.277.352.650.625.716
Concept/Terms	Protein Phosphatase 2C Protein Phosphatase 2C 2C, Protein Phosphatase Phosphatase 2C, Protein PPM1 Protein Phosphatases Phosphatases, PPM1 Protein Protein Phosphatases, PPM1 Ptc2 Phosphatase Phosphatase, Ptc2 PPM1 Magnesium-Dependent Protein Phosphatases PPM1 Magnesium Dependent Protein Phosphatases Protein Phosphatase 2C epsilon Protein Phosphatase 2C epsilon PP2Cepsilon PPM1E Phosphatase Phosphatase, PPM1E Protein Phosphatase 2C beta Protein Phosphatase 2C beta PP2C beta beta, PP2C Ppm1b Phosphatase Phosphatase, Ppm1b Protein Phosphatase 2C delta Protein Phosphatase 2C delta Protein Phosphatase 1D Magnesium-Dependent, delta isoform Protein Phosphatase 1D Magnesium Dependent, delta isoform PPM1D Phosphatase Phosphatase, PPM1D Protein Phosphatase 2C gamma Protein Phosphatase 2C gamma PP2Cgamma PPM1G Phosphatase Phosphatase, PPM1G Magnesium-Dependent Protein Phosphatase 2C beta Magnesium-Dependent Protein Phosphatase 2C beta Magnesium Dependent Protein Phosphatase 2C beta

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2C".

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 2C".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2C".