"DEAD Box Protein 58" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
| Descriptor ID |
D000071457
|
| MeSH Number(s) |
D08.811.913.696.445.735.720.249.750
|
| Concept/Terms |
DEAD Box Protein 58- DEAD Box Protein 58
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
- Probable ATP-Dependent RNA Helicase DDX58
- Probable ATP Dependent RNA Helicase DDX58
- RIG-I-like Receptor 1
- RIG I like Receptor 1
|
Below are MeSH descriptors whose meaning is more general than "DEAD Box Protein 58".
Below are MeSH descriptors whose meaning is more specific than "DEAD Box Protein 58".
This graph shows the total number of publications written about "DEAD Box Protein 58" by people in this website by year, and whether "DEAD Box Protein 58" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "DEAD Box Protein 58" by people in Profiles.
-
DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation. J Med Genet. 2022 03; 59(3):294-304.
-
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. Rheumatol Int. 2014 Oct; 34(10):1401-8.