"Beclin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
| Descriptor ID |
D000071186
|
| MeSH Number(s) |
D12.644.360.075.335 D12.776.094.500 D12.776.476.075.335
|
| Concept/Terms |
Beclin-1- Beclin-1
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- GT197 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- Beclin1
- ATG6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Beclin-1".
Below are MeSH descriptors whose meaning is more specific than "Beclin-1".
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Below are the most recent publications written about "Beclin-1" by people in Profiles.