Methylenetetrahydrofolate Reductase (NADPH2)
"Methylenetetrahydrofolate Reductase (NADPH2)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.
| Descriptor ID |
D042965
|
| MeSH Number(s) |
D08.811.682.662.290 D12.776.331.775
|
| Concept/Terms |
Methylenetetrahydrofolate Reductase (NADPH2)- Methylenetetrahydrofolate Reductase (NADPH2)
- Methylenetetrahydrofolate Reductase (NADPH)
- Methylene-THF Reductase (NADPH)
- Methylenetetrahydrofolate Reductase
- 5,10-Methylenetetrahydrofolate Reductase (NADPH)
- Methylene Tetrahydrofolate Reductase
- Tetrahydrofolate Reductase, Methylene
|
Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Reductase (NADPH2)".
Below are MeSH descriptors whose meaning is more specific than "Methylenetetrahydrofolate Reductase (NADPH2)".
This graph shows the total number of publications written about "Methylenetetrahydrofolate Reductase (NADPH2)" by people in this website by year, and whether "Methylenetetrahydrofolate Reductase (NADPH2)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Methylenetetrahydrofolate Reductase (NADPH2)" by people in Profiles.
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Prenatal Multivitamin Use and MTHFR Genotype Are Associated with Newborn Cord Blood DNA Methylation. Int J Environ Res Public Health. 2020 12 09; 17(24).
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Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. Mol Nutr Food Res. 2013 Apr; 57(4):721-34.
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Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutr Cancer. 2011; 63(3):357-66.
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MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls. Eur J Cancer. 2009 May; 45(8):1443-9.
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Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption. Am J Obstet Gynecol. 2007 Oct; 197(4):385.e1-7.
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Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis. 2007 Aug; 28(8):1672-9.
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Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control. 2007 Mar; 18(2):153-63.
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MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. J Nutr. 2005 Oct; 135(10):2462-7.
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MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 2004 Feb; 13(2):285-92.
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An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. Kidney Int. 2001 Sep; 60(3):1106-13.