Poly(A)-Binding Protein II
"Poly(A)-Binding Protein II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
| Descriptor ID |
D039103
|
| MeSH Number(s) |
D12.776.157.725.452.500 D12.776.664.962.452.500
|
| Concept/Terms |
Poly(A)-Binding Protein II- Poly(A)-Binding Protein II
- PAB2 Poly(A) Binding Protein
- Poly(A) Binding Protein, Nuclear 1
- Pabp2 Gene Product
- Pabp2 Protein
- Poly(A) Binding Protein II
- PAB II
- PABP2
|
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