"Acetazolamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Descriptor ID |
D000086
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| MeSH Number(s) |
D02.886.675.867.060 D03.383.129.708.867.060
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Acetazolamide".
Below are MeSH descriptors whose meaning is more specific than "Acetazolamide".
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Below are the most recent publications written about "Acetazolamide" by people in Profiles.
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Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier. West J Med. 1991 Mar; 154(3):289-93.
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A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis. Am J Med. 1987 Dec; 83(6):1024-30.