Header Logo

Immunoreceptor Tyrosine-Based Activation Motif

"Immunoreceptor Tyrosine-Based Activation Motif" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

expand / collapse MeSH information
A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.


expand / collapse publications
This graph shows the total number of publications written about "Immunoreceptor Tyrosine-Based Activation Motif" by people in this website by year, and whether "Immunoreceptor Tyrosine-Based Activation Motif" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.

© 2024 Kaiser Permanente