Sterol 14-Demethylase

"Sterol 14-Demethylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

Descriptor ID	D058886
MeSH Number(s)	D08.244.453.878.500 D08.244.453.915.880 D08.811.682.690.708.170.499.500 D08.811.682.690.708.170.915.880 D12.776.422.220.453.878.500 D12.776.422.220.453.915.880
Concept/Terms	Sterol 14-Demethylase Sterol 14-Demethylase 14-Demethylase, Sterol Sterol 14 Demethylase Sterol 14-alpha-Demethylase 14-alpha-Demethylase, Sterol Sterol 14 alpha Demethylase Lanosterol 14 alpha-Demethylase 14 alpha-Demethylase, Lanosterol Lanosterol 14 alpha Demethylase CYP51 Cytochrome P-450 CYP51 Cytochrome P 450 Cytochrome P-450, CYP51 P-450, CYP51 Cytochrome Eburicol 14alpha-Demethylase 14alpha-Demethylase, Eburicol Eburicol 14alpha Demethylase Obtusifoliol 14alpha-Demethylase 14alpha-Demethylase, Obtusifoliol Obtusifoliol 14alpha Demethylase Cytochrome P-450 CYP51 CYP51, Cytochrome P-450 Cytochrome P 450 CYP51 P-450 CYP51, Cytochrome Sterol 14-Demethylases 14-Demethylases, Sterol Sterol 14 Demethylases Eburicol 14 alpha-Demethylase 14 alpha-Demethylase, Eburicol Eburicol 14 alpha Demethylase

Below are MeSH descriptors whose meaning is more general than "Sterol 14-Demethylase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 51 [D08.244.453.878]
Sterol 14-Demethylase [D08.244.453.878.500]
Steroid Hydroxylases [D08.244.453.915]
Sterol 14-Demethylase [D08.244.453.915.880]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 51 [D08.811.682.690.708.170.499]
Sterol 14-Demethylase [D08.811.682.690.708.170.499.500]
Steroid Hydroxylases [D08.811.682.690.708.170.915]
Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 51 [D12.776.422.220.453.878]
Sterol 14-Demethylase [D12.776.422.220.453.878.500]
Steroid Hydroxylases [D12.776.422.220.453.915]
Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Below are MeSH descriptors whose meaning is related to "Sterol 14-Demethylase".

Below are MeSH descriptors whose meaning is more specific than "Sterol 14-Demethylase".

publications

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