"Genes, BRCA2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
| Descriptor ID |
D024522
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.105 G05.360.340.024.340.415.400.105
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Genes, BRCA2".
Below are MeSH descriptors whose meaning is more specific than "Genes, BRCA2".
This graph shows the total number of publications written about "Genes, BRCA2" by people in this website by year, and whether "Genes, BRCA2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 1 | 2 | 3 |
| 2007 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Genes, BRCA2" by people in Profiles.
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Screening and Preventative Strategies for Patients at High Risk for Breast Cancer. JCO Oncol Pract. 2021 04; 17(4):e575-e581.
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Sexual function, menopausal symptoms, depression and cancer worry in women with BRCA mutations. Psychooncology. 2020 02; 29(2):331-338.
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Medication Use for the Risk Reduction of Primary Breast Cancer in Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2019 09 03; 322(9):868-886.
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Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2019 08 20; 322(7):666-685.
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Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations. Gynecol Oncol. 2018 12; 151(3):489-493.
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Bone loss in women with BRCA1 and BRCA2 mutations. Gynecol Oncol. 2018 03; 148(3):535-539.
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Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2014 Feb 18; 160(4):255-66.
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Rapid increase in breast magnetic resonance imaging use: trends from 2000 to 2011. JAMA Intern Med. 2014 Jan; 174(1):114-21.
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Risk management options elected by women after testing positive for a BRCA mutation. Gynecol Oncol. 2014 Feb; 132(2):428-33.
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Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians. Am J Prev Med. 2011 Jan; 40(1):61-6.