"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
| Descriptor ID |
D027081
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| MeSH Number(s) |
D08.811.399.403.741.149 D12.776.097.237
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".
Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".
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Below are the most recent publications written about "DNA Gyrase" by people in Profiles.
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Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli. J Infect Dis. 2013 Mar 15; 207(6):919-28.