Pregnancy-Associated Plasma Protein-A

"Pregnancy-Associated Plasma Protein-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

Descriptor ID	D011266
MeSH Number(s)	D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700
Concept/Terms	Pregnancy-Associated Plasma Protein-A Pregnancy-Associated Plasma Protein-A Pregnancy Associated Plasma Protein A IGFBP-4 Protease IGFBP 4 Protease Protease, IGFBP-4 IGFBP-4-Specific Proteinase Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease PAPP-A PAPP-alpha PAPP alpha Pregnancy Associated alpha Plasma Protein Pregnancy-Associated alpha-Plasma Protein IGFBP-4 Metalloproteinase IGFBP 4 Metalloproteinase Metalloproteinase, IGFBP-4 Insulin-Like-Growth Factor Binding Protein-4 Protease Insulin Like Growth Factor Binding Protein 4 Protease

Below are MeSH descriptors whose meaning is more general than "Pregnancy-Associated Plasma Protein-A".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Metalloendopeptidases [D08.811.277.656.300.480]
Pregnancy-Associated Plasma Protein-A [D08.811.277.656.300.480.632]
Metalloproteases [D08.811.277.656.675]
Metalloendopeptidases [D08.811.277.656.675.374]
Pregnancy-Associated Plasma Protein-A [D08.811.277.656.675.374.632]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Pregnancy Proteins [D12.776.780]
Pregnancy-Associated Plasma Protein-A [D12.776.780.700]

Below are MeSH descriptors whose meaning is more specific than "Pregnancy-Associated Plasma Protein-A".

publications

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