Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).

Descriptor ID	D016511
MeSH Number(s)	C16.614.815 C18.452.284.800 C20.673.815
Concept/Terms	Severe Combined Immunodeficiency Severe Combined Immunodeficiency Combined Immunodeficiencies, Severe Combined Immunodeficiency, Severe Immunodeficiencies, Severe Combined Severe Combined Immunodeficiencies Immunodeficiency, Severe Combined Severe Combined Immune Deficiency Severe Combined Immunodeficiency Syndrome Severe Combined Immunologic Deficiency Immunodeficiency Syndrome, Severe Combined Immunologic Deficiency, Severe Combined Bare Lymphocyte Syndrome Bare Lymphocyte Syndrome Bare Lymphocyte Syndromes Lymphocyte Syndrome, Bare Lymphocyte Syndromes, Bare Syndrome, Bare Lymphocyte Syndromes, Bare Lymphocyte Omenn Syndrome Omenn Syndrome Syndrome, Omenn Reticuloendotheliosis, Familial Familial Reticuloendothelioses Familial Reticuloendotheliosis Reticuloendothelioses, Familial Omenn's Syndrome Omenns Syndrome Syndrome, Omenn's

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