"Droxidopa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
| Descriptor ID |
D015103
|
| MeSH Number(s) |
D02.092.211.215.311.560.220 D02.092.311.830.220 D12.125.154.800.875
|
| Concept/Terms |
Droxidopa- Droxidopa
- threo-DOPS
- threo DOPS
- 3,4-threo-DOPS
- 3,4 threo DOPS
- DL-threo-3,4-Dihydroxyphenylserine
- DL threo 3,4 Dihydroxyphenylserine
|
Below are MeSH descriptors whose meaning is more general than "Droxidopa".
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