"Receptors, LDL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
| Descriptor ID |
D011973
|
| MeSH Number(s) |
D12.776.543.750.710.450
|
| Concept/Terms |
Receptors, LDL- Receptors, LDL
- LDL Receptors
- LDL Receptors, Lipoprotein
- Receptors, Lipoprotein LDL
- Lipoprotein LDL Receptors
- Low Density Lipoprotein Receptors
- Receptors, Lipoprotein, LDL
- Receptors, Low Density Lipoprotein
- LDL Receptor
- Receptor, LDL
- Low Density Lipoprotein Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptors, LDL".
Below are MeSH descriptors whose meaning is more specific than "Receptors, LDL".
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