Neuroleptic Malignant Syndrome

"Neuroleptic Malignant Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

Descriptor ID	D009459
MeSH Number(s)	C10.228.140.079.737 C10.720.737 C25.723.705.600
Concept/Terms	Neuroleptic Malignant Syndrome Neuroleptic Malignant Syndrome Neuroleptic Malignant Syndromes Syndrome, Neuroleptic Malignant Syndromes, Neuroleptic Malignant NMS (Neuroleptic Malignant Syndrome) NMSs (Neuroleptic Malignant Syndrome) Neuroleptic-Induced Neuroleptic Malignant Syndrome Neuroleptic-Induced Neuroleptic Malignant Syndrome Neuroleptic Induced Neuroleptic Malignant Syndrome Neuroleptic-Malignant Syndrome, Neuroleptic Induced Neuroleptic Malignant Syndrome, Neuroleptic Induced

Below are MeSH descriptors whose meaning is more general than "Neuroleptic Malignant Syndrome".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Basal Ganglia Diseases [C10.228.140.079]
Neuroleptic Malignant Syndrome [C10.228.140.079.737]
Neurotoxicity Syndromes [C10.720]
Neuroleptic Malignant Syndrome [C10.720.737]
Chemically-Induced Disorders [C25]
Poisoning [C25.723]
Neurotoxicity Syndromes [C25.723.705]
Neuroleptic Malignant Syndrome [C25.723.705.600]

Below are MeSH descriptors whose meaning is more specific than "Neuroleptic Malignant Syndrome".

publications

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