"Apolipoprotein E2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D053329
|
| MeSH Number(s) |
D10.532.091.500.249 D12.776.070.400.500.249 D12.776.521.120.500.249
|
| Concept/Terms |
Apolipoprotein E2- Apolipoprotein E2
- APOE-epsilon2
- APOE epsilon2
- ApoE2
- APOE-epsilon 2
- APOE epsilon 2
- Apo E-2
- Apo E 2
- Apo E2
- Apolipoprotein E-epsilon2
- Apolipoprotein E epsilon2
- Apolipoprotein E-2
- Apolipoprotein E 2
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E2".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E2".
This graph shows the total number of publications written about "Apolipoprotein E2" by people in this website by year, and whether "Apolipoprotein E2" was a major or minor topic of these publications.
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Below are the most recent publications written about "Apolipoprotein E2" by people in Profiles.
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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667.
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Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations. Neurosurgery. 2006 May; 58(5):838-43; discussion 838-43.