"COP9 Signalosome Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Descriptor ID |
D000075686
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MeSH Number(s) |
D05.500.139 D08.811.037.750.250 D08.811.277.656.300.887.375
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Concept/Terms |
COP9 Signalosome Complex- COP9 Signalosome Complex
- Signalosome Complex, COP9
- Constitutive Photomorphogenesis 9 Signalsome
- COP9 Signalsome
- Signalsome, COP9
- Constitutive Photomorphogenesis 9 Signalosome
- COP9 Signalosome (CSN)
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Below are MeSH descriptors whose meaning is more general than "COP9 Signalosome Complex".
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