High-Temperature Requirement A Serine Peptidase 1
"High-Temperature Requirement A Serine Peptidase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
| Descriptor ID |
D000074289
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| MeSH Number(s) |
D08.811.277.656.300.760.420 D08.811.277.656.959.350.420
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "High-Temperature Requirement A Serine Peptidase 1".
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This graph shows the total number of publications written about "High-Temperature Requirement A Serine Peptidase 1" by people in this website by year, and whether "High-Temperature Requirement A Serine Peptidase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "High-Temperature Requirement A Serine Peptidase 1" by people in Profiles.
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Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet. 2024 Dec; 56(12):2659-2671.