"Cytokine TWEAK" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
| Descriptor ID |
D000074049
|
| MeSH Number(s) |
D12.644.276.374.750.155 D12.776.467.374.750.155 D23.529.374.750.155
|
| Concept/Terms |
Cytokine TWEAK- Cytokine TWEAK
- TWEAK, Cytokine
- TNF-Related Weak Inducer of Apoptosis
- TNF Related Weak Inducer of Apoptosis
- TWEAK Cytokine
- Cytokine, TWEAK
- Tumor Necrosis Factor Ligand Superfamily Member 12
- Apo3 Ligand
- Ligand, Apo3
|
Below are MeSH descriptors whose meaning is more general than "Cytokine TWEAK".
Below are MeSH descriptors whose meaning is more specific than "Cytokine TWEAK".
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Below are the most recent publications written about "Cytokine TWEAK" by people in Profiles.