Src Homology 2 Domain-Containing, Transforming Protein 1

"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

Descriptor ID	D000071425
MeSH Number(s)	D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
Concept/Terms	Src Homology 2 Domain-Containing, Transforming Protein 1 Src Homology 2 Domain-Containing, Transforming Protein 1 Src Homology 2 Domain Containing, Transforming Protein 1 ShcA Protein SHC1 (Src Homology 2 Domain-Containing) Protein Src Homology 2 Domain-Containing-Transforming Protein C1 Src Homology 2 Domain Containing Transforming Protein C1 SHC (Src Homology 2 Domain-Containing) Transforming Protein 1 SHC1 Protein SHC-Transforming Protein 1 SHC Transforming Protein 1

Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Shc Signaling Adaptor Proteins [D12.644.360.024.330]
Src Homology 2 Domain-Containing, Transforming Protein 1 [D12.644.360.024.330.500]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Shc Signaling Adaptor Proteins [D12.776.157.057.162]
Src Homology 2 Domain-Containing, Transforming Protein 1 [D12.776.157.057.162.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Shc Signaling Adaptor Proteins [D12.776.476.024.424]
Src Homology 2 Domain-Containing, Transforming Protein 1 [D12.776.476.024.424.500]

Below are MeSH descriptors whose meaning is related to "Src Homology 2 Domain-Containing, Transforming Protein 1".

Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".

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