"Proprotein Convertase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
| Descriptor ID |
D045664
|
| MeSH Number(s) |
D08.811.277.656.300.760.640 D08.811.277.656.837.500 D08.811.277.656.959.350.640
|
| Concept/Terms |
Proprotein Convertase 1- Proprotein Convertase 1
- Convertase 1, Proprotein
- PC1 Prohormone Convertase
- PC3 Endoprotease
- Endoprotease, PC3
- PC3 Prohormone Convertase
- Convertase, PC3 Prohormone
- Prohormone Convertase, PC3
- Neuroendocrine Convertase PC1
- Convertase PC1, Neuroendocrine
- Proprotein Convertase SPC3
- Convertase SPC3, Proprotein
- Proinsulin Convertase 1
- Prohormone Convertase 3
- Prohormone Convertase, PC1
- Convertase, PC1 Prohormone
- PC1 Endoprotease
- Endoprotease, PC1
- Prohormone Convertase 1
|
Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 1".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 1".
This graph shows the total number of publications written about "Proprotein Convertase 1" by people in this website by year, and whether "Proprotein Convertase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 1" by people in Profiles.
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Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Hum Mol Genet. 2015 Jun 15; 24(12):3582-94.
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Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population. PLoS One. 2013; 8(2):e57857.
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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes. 2012 Feb; 61(2):383-90.
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Genetic and functional characterization of PCSK1. Methods Mol Biol. 2011; 768:247-53.