Histamine H1 Antagonists, Non-Sedating
"Histamine H1 Antagonists, Non-Sedating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
| Descriptor ID |
D039563
|
| MeSH Number(s) |
D27.505.519.625.375.425.400.500 D27.505.696.577.375.425.400.500
|
| Concept/Terms |
Histamine H1 Antagonists, Non-Sedating- Histamine H1 Antagonists, Non-Sedating
- Histamine H1 Antagonists, Non Sedating
- Second Generation H1 Antagonists
- H1 Antihistamines, Non-Sedating
- H1 Antihistamines, Non Sedating
- Non-Sedating H1 Antihistamines
- Second Generation Antihistamines
- Antihistamines, Second Generation
|
Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists, Non-Sedating".
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