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Gregory N Clarke, PhD

TitleSenior Investigator
InstitutionKaiser Permanente Northwest
DepartmentCenter for Health Research - Northwest
ORCID ORCID Icon0000-0002-4529-8694 Additional info
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    Other Positions
    TitleAssociate Director, Science Programs
    InstitutionKaiser Permanente Northwest
    DepartmentCenter for Health Research - Northwest

    TitleCenter for Health Research Distinguished Investigator
    InstitutionKaiser Permanente Northwest
    DepartmentCenter for Health Research - Northwest


    Collapse Overview 
    Collapse overview
    Dr. Greg Clarke’s areas of interest include the prevention and treatment of depression, anxiety, and insomnia in both adults and youth as well as population-level mental health improvement through the use of e-health interventions (e.g., websites, mobile devices).

    Dr. Clarke has been the principal investigator and co-investigator on over a dozen grants funded by the National Institute of Mental Health, conducting controlled-outcome trials of depression treatment and prevention in at-risk populations. Some of his most recent controlled trials have examined the costs and clinical outcomes of preventing and treating depression in adolescent offspring of depressed parents enrolled in an HMO, the medication and psychotherapy treatment of depression in adolescents who have failed to respond to an initial antidepressant medication, simultaneous insomnia treatment and antidepressant medication for depressed youth, and Internet self-care programs for depressed adults and adolescents.

    Dr. Clarke received his PhD in clinical psychology from the University of Oregon in 1985, and has conducted mental health research for over 30 years.

    Collapse Research 
    Collapse research activities and funding
    R03MH048118     (CLARKE, GREGORY N)Feb 1, 1991 - Jan 31, 1995
    NIH/NIMH
    SCHOOL BASED PREVENTION OF ADOLESCENT DEPRESSION
    Role: Principal Investigator

    R01MH051318     (CLARKE, GREGORY N)May 1, 1994 - Apr 30, 2000
    NIH/NIMH
    HMO SERVICE MODEL FOR OFFSPRING OF DEPRESSED PARENTS
    Role: Principal Investigator

    R01HS010535     (CLARKE, GREGORY N)Jun 1, 1999 - May 31, 2004
    AHRQ
    HMO COLLABORATIVE CARE TREATMENT FOR DEPRESSED YOUTH
    Role: Principal Investigator

    R01AA011733     (CLARKE, GREGORY N)Jul 1, 1999 - Mar 31, 2005
    NIH/NIAAA
    HMO TREATMENT OF DEPRESSION &SUBSTANCE ABUSE
    Role: Principal Investigator

    R24MH061422     (CLARKE, GREGORY N)Aug 17, 2000 - May 31, 2006
    NIH/NIMH
    INTERNET-BASED INTERVENTIONS FOR YOUTH DISORDERS
    Role: Principal Investigator

    U01MH061869     (CLARKE, GREGORY N)Sep 25, 2000 - Aug 31, 2008
    NIH/NIMH
    Treatment of Resistant Depression in Adolescents 2
    Role: Principal Investigator

    R01MH064541     (CLARKE, GREGORY N)Dec 1, 2001 - Dec 31, 2013
    NIH/NIMH
    4/4-Prevention of Depression: Impact on Transition to Early Adulthood
    Role: Principal Investigator

    R01HS013854     (CLARKE, GREGORY N)Sep 30, 2002 - Mar 31, 2005
    AHRQ
    Followup of Depressed Adolescents Receiving CBT + SSRIs
    Role: Principal Investigator

    R01MH073918     (CLARKE, GREGORY N)Jul 1, 2006 - Apr 30, 2012
    NIH/NIMH
    Brief, Primary Care CBT for Unmedicated Depressed Youth
    Role: Principal Investigator

    R34MH082034     (CLARKE, GREGORY N)Sep 8, 2008 - Jun 30, 2012
    NIH/NIMH
    Development and Piloting of CBT for Insomnia in Youth with Comorbid Depression
    Role: Principal Investigator

    R01MH090160     (CLARKE, GREGORY N)Apr 1, 2010 - Mar 31, 2014
    NIH/NIMH
    Antidepressant Adherence via Telephonic Interactive Voice Recognition (IVR)
    Role: Principal Investigator

    R01MH087505     (CLARKE, GREGORY N)Sep 1, 2010 - Jun 30, 2015
    NIH/NIMH
    Internet CBT for Depression: Comparing Pure, Guided, and Stepped Care
    Role: Principal Investigator

    R01MH101118     (CLARKE, GREGORY N)May 1, 2014 - Mar 31, 2019
    NIH/NIMH
    An Efficacy-Effectiveness Trial of Cognitive Bias Modification for Youth Anxiety
    Role: Principal Investigator

    R01MH104647     (CLARKE, GREGORY N)Sep 5, 2014 - Aug 31, 2018
    NIH/NIMH
    CBT-Insomnia Augmenting Usual Care SSRIs to Improve Youth Depression Outcomes
    Role: Principal Investigator

    R01MH112147     (ASARNOW, JOAN ROSENBAUM)Sep 1, 2016 - Aug 31, 2021
    NIH/NIMH
    Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kavanaugh BC, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Schneider MB, Carpenter LL. Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation With a 2-Coil Device in Treatment-Resistant Major Depressive Disorder. J ECT. 2018 Dec; 34(4):258-265. PMID: 29613944.
      View in: PubMed
    2. Lu CY, Penfold RB, Toh S, Sturtevant JL, Madden JM, Simon G, Ahmedani BK, Clarke G, Coleman KJ, Copeland LA, Daida YG, Davis RL, Hunkeler EM, Owen-Smith A, Raebel MA, Rossom R, Soumerai SB, Kulldorff M. Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis. Med Care. 2018 May; 56(5):365-372. PMID: 29634627.
      View in: PubMed
    3. Garber J, Weersing VR, Hollon SD, Porta G, Clarke GN, Dickerson JF, Beardslee WR, Lynch FL, Gladstone TG, Shamseddeen W, Brent DA. Prevention of Depression in At-Risk Adolescents: Moderators of Long-term Response. Prev Sci. 2018 Feb; 19(Suppl 1):6-15. PMID: 26830893.
      View in: PubMed
    4. Dickerson JF, Lynch FL, Leo MC, DeBar LL, Pearson J, Clarke GN. Cost-effectiveness of Cognitive Behavioral Therapy for Depressed Youth Declining Antidepressants. Pediatrics. 2018 Feb; 141(2). PMID: 29351965.
      View in: PubMed
    5. Dickerson JF, Feeny DH, Clarke GN, MacMillan AL, Lynch FL. Evidence on the longitudinal construct validity of major generic and utility measures of health-related quality of life in teens with depression. Qual Life Res. 2018 02; 27(2):447-454. PMID: 29149441.
      View in: PubMed
    6. Carpenter LL, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Stannard EL, Schneider MB. rTMS with a two-coil array: Safety and efficacy for treatment resistant major depressive disorder. Brain Stimul. 2017 Sep - Oct; 10(5):926-933. PMID: 28642024.
      View in: PubMed
    7. Lynch FL, Dickerson JF, Feeny DH, Clarke GN, MacMillan AL. Measuring Health-related Quality of Life in Teens With and Without Depression. Med Care. 2016 Dec; 54(12):1089-1097. PMID: 27261639.
      View in: PubMed
    8. Clarke G, DeBar LL, Pearson JA, Dickerson JF, Lynch FL, Gullion CM, Leo MC. Cognitive Behavioral Therapy in Primary Care for Youth Declining Antidepressants: A Randomized Trial. Pediatrics. 2016 May; 137(5). PMID: 27244782; PMCID: PMC4845864 [Available on 05/01/17].
    9. Weersing VR, Shamseddeen W, Garber J, Hollon SD, Clarke GN, Beardslee WR, Gladstone TR, Lynch FL, Porta G, Iyengar S, Brent DA. Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. J Am Acad Child Adolesc Psychiatry. 2016 Mar; 55(3):219-26. PMID: 26903255.
      View in: PubMed
    10. Brent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Nov; 72(11):1110-8. PMID: 26421861; PMCID: PMC4635056 [Available on 11/01/16].
    11. Clarke G, McGlinchey EL, Hein K, Gullion CM, Dickerson JF, Leo MC, Harvey AG. Cognitive-behavioral treatment of insomnia and depression in adolescents: A pilot randomized trial. Behav Res Ther. 2015 Jun; 69:111-8. PMID: 25917009; PMCID: PMC4418229.
    12. Richardson LP, Ludman E, McCauley E, Lindenbaum J, Larison C, Zhou C, Clarke G, Brent D, Katon W. Collaborative care for adolescents with depression in primary care: a randomized clinical trial. JAMA. 2014 Aug 27; 312(8):809-16. PMID: 25157724; PMCID: PMC4492537.
    13. Lu CY, Zhang F, Lakoma MD, Madden JM, Rusinak D, Penfold RB, Simon G, Ahmedani BK, Clarke G, Hunkeler EM, Waitzfelder B, Owen-Smith A, Raebel MA, Rossom R, Coleman KJ, Copeland LA, Soumerai SB. Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. BMJ. 2014 Jun 18; 348:g3596. PMID: 24942789; PMCID: PMC4062705.
    14. Beardslee WR, Brent DA, Weersing VR, Clarke GN, Porta G, Hollon SD, Gladstone TR, Gallop R, Lynch FL, Iyengar S, DeBar L, Garber J. Prevention of depression in at-risk adolescents: longer-term effects. JAMA Psychiatry. 2013 Nov; 70(11):1161-70. PMID: 24005242; PMCID: PMC3978119.
    15. Lewandowski RE, Acri MC, Hoagwood KE, Olfson M, Clarke G, Gardner W, Scholle SH, Byron S, Kelleher K, Pincus HA, Frank S, Horwitz SM. Evidence for the management of adolescent depression. Pediatrics. 2013 Oct; 132(4):e996-e1009. PMID: 24043282; PMCID: PMC4074649.
    16. Mansoor B, Rengasamy M, Hilton R, Porta G, He J, Spirito A, Emslie GJ, Mayes TL, Clarke G, Wagner KD, Shamseddeen W, Birmaher B, Ryan N, Brent D. The bidirectional relationship between body mass index and treatment outcome in adolescents with treatment-resistant depression. J Child Adolesc Psychopharmacol. 2013 Sep; 23(7):458-67. PMID: 24024532.
      View in: PubMed
    17. Tham SW, Holley AL, Zhou C, Clarke GN, Palermo TM. Longitudinal course and risk factors for fatigue in adolescents: the mediating role of sleep disturbances. J Pediatr Psychol. 2013 Nov; 38(10):1070-80. PMID: 23860262; PMCID: PMC3809725.
    18. Clarke G, Yarborough BJ. Evaluating the promise of health IT to enhance/expand the reach of mental health services. Gen Hosp Psychiatry. 2013 Jul-Aug; 35(4):339-44. PMID: 23701698; PMCID: PMC3716575.
    19. Mohr DC, Burns MN, Schueller SM, Clarke G, Klinkman M. Behavioral intervention technologies: evidence review and recommendations for future research in mental health. Gen Hosp Psychiatry. 2013 Jul-Aug; 35(4):332-8. PMID: 23664503; PMCID: PMC3719158.
    20. Debar LL, Wilson GT, Yarborough BJ, Burns B, Oyler B, Hildebrandt T, Clarke GN, Dickerson J, Striegel RH. Cognitive Behavioral Treatment for Recurrent Binge Eating in Adolescent Girls: A Pilot Trial. Cogn Behav Pract. 2013 May 01; 20(2):147-161. PMID: 23645978.
      View in: PubMed
    21. Hilton RC, Rengasamy M, Mansoor B, He J, Mayes T, Emslie GJ, Porta G, Clarke GN, Wagner KD, Birmaher B, Keller MB, Ryan N, Shamseddeen W, Asarnow JR, Brent DA. Impact of treatments for depression on comorbid anxiety, attentional, and behavioral symptoms in adolescents with selective serotonin reuptake inhibitor-resistant depression. J Am Acad Child Adolesc Psychiatry. 2013 May; 52(5):482-92. PMID: 23622849; PMCID: PMC3756470.
    22. Rengasamy M, Mansoor BM, Hilton R, Porta G, He J, Emslie GJ, Mayes T, Clarke GN, Wagner KD, Keller MB, Ryan ND, Birmaher B, Shamseddeen W, Asarnow JR, Brent DA. The bi-directional relationship between parent-child conflict and treatment outcome in treatment-resistant adolescent depression. J Am Acad Child Adolesc Psychiatry. 2013 Apr; 52(4):370-7. PMID: 23582868; PMCID: PMC3737571.
    23. Lewandowski Holley A, Law EF, Zhou C, Murphy L, Clarke G, Palermo TM. Reciprocal longitudinal associations between pain and depressive symptoms in adolescents. Eur J Pain. 2013 Aug; 17(7):1058-67. PMID: 23280775; PMCID: PMC3620896.
    24. Paulk NK, Wursthorn K, Haft A, Pelz C, Clarke G, Newell AH, Olson SB, Harding CO, Finegold MJ, Bateman RL, Witte JF, McClard R, Grompe M. In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice. Mol Ther. 2012 Oct; 20(10):1981-7. PMID: 22871666; PMCID: PMC3464641.
    25. Clarke G, Harvey AG. The complex role of sleep in adolescent depression. Child Adolesc Psychiatr Clin N Am. 2012 Apr; 21(2):385-400. PMID: 22537732; PMCID: PMC3605974.
    26. Murray CB, Murphy LK, Palermo TM, Clarke GM. Pain and sleep-wake disturbances in adolescents with depressive disorders. J Clin Child Adolesc Psychol. 2012; 41(4):482-90. PMID: 22420746; PMCID: PMC3538877.
    27. McMakin DL, Olino TM, Porta G, Dietz LJ, Emslie G, Clarke G, Wagner KD, Asarnow JR, Ryan ND, Birmaher B, Shamseddeen W, Mayes T, Kennard B, Spirito A, Keller M, Lynch FL, Dickerson JF, Brent DA. Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression. J Am Acad Child Adolesc Psychiatry. 2012 Apr; 51(4):404-11. PMID: 22449646; PMCID: PMC3536476.
    28. Maalouf FT, Porta G, Vitiello B, Emslie G, Mayes T, Clarke G, Wagner KD, Asarnow JR, Spirito A, Keller M, Birmaher B, Ryan N, Shamseddeen W, Iyengar S, Brent D. Do sub-syndromal manic symptoms influence outcome in treatment resistant depression in adolescents? A latent class analysis from the TORDIA study. J Affect Disord. 2012 Apr; 138(1-2):86-95. PMID: 22284022.
      View in: PubMed
    29. Wagner KD, Asarnow JR, Vitiello B, Clarke G, Keller M, Emslie GJ, Ryan N, Porta G, Iyengar S, Ritz L, Zelanzny J, Onorato M, Brent D. Out of the black box: treatment of resistant depression in adolescents and the antidepressant controversy. J Child Adolesc Psychopharmacol. 2012 Feb; 22(1):5-10. PMID: 22251022; PMCID: PMC3281287.
    30. Shamseddeen W, Clarke G, Keller MB, Wagner KD, Birmaher B, Emslie GJ, Ryan N, Asarnow JR, Porta G, Brent DA. Adjunctive sleep medications and depression outcome in the treatment of serotonin-selective reuptake inhibitor resistant depression in adolescents study. J Child Adolesc Psychopharmacol. 2012 Feb; 22(1):29-36. PMID: 22251024.
      View in: PubMed
    31. Clarke G, Dickerson J, Gullion CM, DeBar LL. Trends in youth antidepressant dispensing and refill limits, 2000 through 2009. J Child Adolesc Psychopharmacol. 2012 Feb; 22(1):11-20. PMID: 22251026.
      View in: PubMed
    32. Shamseddeen W, Clarke G, Wagner KD, Ryan ND, Birmaher B, Emslie G, Asarnow JR, Porta G, Mayes T, Keller MB, Brent DA. Treatment-resistant depressed youth show a higher response rate if treatment ends during summer school break. J Am Acad Child Adolesc Psychiatry. 2011 Nov; 50(11):1140-8. PMID: 22024002.
      View in: PubMed
    33. Asarnow JR, Porta G, Spirito A, Emslie G, Clarke G, Wagner KD, Vitiello B, Keller M, Birmaher B, McCracken J, Mayes T, Berk M, Brent DA. Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA study. J Am Acad Child Adolesc Psychiatry. 2011 Aug; 50(8):772-81. PMID: 21784297; PMCID: PMC3143365.
    34. Woldu H, Porta G, Goldstein T, Sakolsky D, Perel J, Emslie G, Mayes T, Clarke G, Ryan ND, Birmaher B, Wagner KD, Asarnow JR, Keller MB, Brent D. Pharmacokinetically and clinician-determined adherence to an antidepressant regimen and clinical outcome in the TORDIA trial. J Am Acad Child Adolesc Psychiatry. 2011 May; 50(5):490-8. PMID: 21515198; PMCID: PMC3621085.
    35. Vitiello B, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller MB, Birmaher B, Ryan ND, Kennard B, Mayes TL, DeBar L, Lynch F, Dickerson J, Strober M, Suddath R, McCracken JT, Spirito A, Onorato M, Zelazny J, Porta G, Iyengar S, Brent DA. Long-term outcome of adolescent depression initially resistant to selective serotonin reuptake inhibitor treatment: a follow-up study of the TORDIA sample. J Clin Psychiatry. 2011 Mar; 72(3):388-96. PMID: 21208583; PMCID: PMC3070064.
    36. Lynch FL, Dickerson JF, Clarke G, Vitiello B, Porta G, Wagner KD, Emslie G, Asarnow JR, Keller MB, Birmaher B, Ryan ND, Kennard B, Mayes T, DeBar L, McCracken JT, Strober M, Suddath RL, Spirito A, Onorato M, Zelazny J, Iyengar S, Brent D. Incremental cost-effectiveness of combined therapy vs medication only for youth with selective serotonin reuptake inhibitor-resistant depression: treatment of SSRI-resistant depression in adolescents trial findings. Arch Gen Psychiatry. 2011 Mar; 68(3):253-62. PMID: 21383263; PMCID: PMC3679348.
    37. Sakolsky DJ, Perel JM, Emslie GJ, Clarke GN, Wagner KD, Vitiello B, Keller MB, Birmaher B, Asarnow JR, Ryan ND, McCracken JT, Strober MJ, Iyengar S, Porta G, Brent DA. Antidepressant exposure as a predictor of clinical outcomes in the Treatment of Resistant Depression in Adolescents (TORDIA) study. J Clin Psychopharmacol. 2011 Feb; 31(1):92-7. PMID: 21192150; PMCID: PMC3603695.
    38. Shamseddeen W, Asarnow JR, Clarke G, Vitiello B, Wagner KD, Birmaher B, Keller MB, Emslie G, Iyengar S, Ryan ND, McCracken JT, Porta G, Mayes T, Brent DA. Impact of physical and sexual abuse on treatment response in the Treatment of Resistant Depression in Adolescent Study (TORDIA). J Am Acad Child Adolesc Psychiatry. 2011 Mar; 50(3):293-301. PMID: 21334569.
      View in: PubMed
    39. Emslie GJ, Mayes T, Porta G, Vitiello B, Clarke G, Wagner KD, Asarnow JR, Spirito A, Birmaher B, Ryan N, Kennard B, DeBar L, McCracken J, Strober M, Onorato M, Zelazny J, Keller M, Iyengar S, Brent D. Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomes. Am J Psychiatry. 2010 Jul; 167(7):782-91. PMID: 20478877; PMCID: PMC3257891.
    40. Brent D, Melhem N, Ferrell R, Emslie G, Wagner KD, Ryan N, Vitiello B, Birmaher B, Mayes T, Zelazny J, Onorato M, Devlin B, Clarke G, DeBar L, Keller M. Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study. Am J Psychiatry. 2010 Feb; 167(2):190-7. PMID: 20008943; PMCID: PMC2887294.
    41. Goldstein BI, Shamseddeen W, Spirito A, Emslie G, Clarke G, Wagner KD, Asarnow JR, Vitiello B, Ryan N, Birmaher B, Mayes T, Onorato M, Zelazny J, Brent DA. Substance use and the treatment of resistant depression in adolescents. J Am Acad Child Adolesc Psychiatry. 2009 Dec; 48(12):1182-92. PMID: 19858762.
      View in: PubMed
    42. Kennard BD, Clarke GN, Weersing VR, Asarnow JR, Shamseddeen W, Porta G, Berk M, Hughes JL, Spirito A, Emslie GJ, Keller MB, Wagner KD, Brent DA. Effective components of TORDIA cognitive-behavioral therapy for adolescent depression: preliminary findings. J Consult Clin Psychol. 2009 Dec; 77(6):1033-41. PMID: 19968380.
      View in: PubMed
    43. Garber J, Clarke GN, Weersing VR, Beardslee WR, Brent DA, Gladstone TR, DeBar LL, Lynch FL, D'Angelo E, Hollon SD, Shamseddeen W, Iyengar S. Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA. 2009 Jun 03; 301(21):2215-24. PMID: 19491183.
      View in: PubMed
    44. Spirito A, Abebe KZ, Iyengar S, Brent D, Vitiello B, Clarke G, Wagner KD, Asarnow J, Emslie G, Keller M. Sources of site differences in the efficacy of a multisite clinical trial: the Treatment of SSRI-Resistant Depression in Adolescents. J Consult Clin Psychol. 2009 Jun; 77(3):439-50. PMID: 19485586; PMCID: PMC2692068.
    45. Cuijpers P, Muñoz RF, Clarke GN, Lewinsohn PM. Psychoeducational treatment and prevention of depression: the "Coping with Depression" course thirty years later. Clin Psychol Rev. 2009 Jul; 29(5):449-58. PMID: 19450912.
      View in: PubMed
    46. Asarnow JR, Emslie G, Clarke G, Wagner KD, Spirito A, Vitiello B, Iyengar S, Shamseddeen W, Ritz L, Mccracken J, Strober M, Suddath R, Leonard H, Porta G, Keller M, Brent D. Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response. J Am Acad Child Adolesc Psychiatry. 2009 Mar; 48(3):330-9. PMID: 19182688.
      View in: PubMed
    47. Brent DA, Emslie GJ, Clarke GN, Asarnow J, Spirito A, Ritz L, Vitiello B, Iyengar S, Birmaher B, Ryan ND, Zelazny J, Onorato M, Kennard B, Mayes TL, Debar LL, McCracken JT, Strober M, Suddath R, Leonard H, Porta G, Keller MB. Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study. Am J Psychiatry. 2009 Apr; 166(4):418-26. PMID: 19223438; PMCID: PMC3593721.
    48. Clarke G, Kelleher C, Hornbrook M, Debar L, Dickerson J, Gullion C. Randomized effectiveness trial of an Internet, pure self-help, cognitive behavioral intervention for depressive symptoms in young adults. Cogn Behav Ther. 2009; 38(4):222-34. PMID: 19440896; PMCID: PMC2829099.
    49. DeBar LL, Dickerson J, Clarke G, Stevens VJ, Ritenbaugh C, Aickin M. Using a website to build community and enhance outcomes in a group, multi-component intervention promoting healthy diet and exercise in adolescents. J Pediatr Psychol. 2009 Jun; 34(5):539-50. PMID: 19091807; PMCID: PMC2722139.
    50. Brent D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, Vitiello B, Ritz L, Iyengar S, Abebe K, Birmaher B, Ryan N, Kennard B, Hughes C, DeBar L, McCracken J, Strober M, Suddath R, Spirito A, Leonard H, Melhem N, Porta G, Onorato M, Zelazny J. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA. 2008 Feb 27; 299(8):901-13. PMID: 18314433; PMCID: PMC2277341.
    51. Zuckerbrot RA, Cheung AH, Jensen PS, Stein RE, Laraque D. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): I. Identification, assessment, and initial management. Pediatrics. 2007 Nov; 120(5):e1299-312. PMID: 17974723.
      View in: PubMed
    52. Cheung AH, Zuckerbrot RA, Jensen PS, Ghalib K, Laraque D, Stein RE. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): II. Treatment and ongoing management. Pediatrics. 2007 Nov; 120(5):e1313-26. PMID: 17974724.
      View in: PubMed
    53. Lynch FL, Clarke GN. Estimating the economic burden of depression in children and adolescents. Am J Prev Med. 2006 Dec; 31(6 Suppl 1):S143-51. PMID: 17175409.
      View in: PubMed
    54. Wisdom JP, Clarke GN, Green CA. What teens want: barriers to seeking care for depression. Adm Policy Ment Health. 2006 Mar; 33(2):133-45. PMID: 16489480; PMCID: PMC3551284.
    55. Rohde P, Seeley JR, Kaufman NK, Clarke GN, Stice E. Predicting time to recovery among depressed adolescents treated in two psychosocial group interventions. J Consult Clin Psychol. 2006 Feb; 74(1):80-8. PMID: 16551145; PMCID: PMC2248603.
    56. Lynch FL, Hornbrook M, Clarke GN, Perrin N, Polen MR, O'Connor E, Dickerson J. Cost-effectiveness of an intervention to prevent depression in at-risk teens. Arch Gen Psychiatry. 2005 Nov; 62(11):1241-8. PMID: 16275811.
      View in: PubMed
    57. Clarke G, Debar L, Lynch F, Powell J, Gale J, O'Connor E, Ludman E, Bush T, Lin EH, Von Korff M, Hertert S. A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. J Am Acad Child Adolesc Psychiatry. 2005 Sep; 44(9):888-98. PMID: 16113617.
      View in: PubMed
    58. Clarke G, Eubanks D, Reid E, Kelleher C, O'Connor E, DeBar LL, Lynch F, Nunley S, Gullion C. Overcoming Depression on the Internet (ODIN) (2): a randomized trial of a self-help depression skills program with reminders. J Med Internet Res. 2005 Jun 21; 7(2):e16. PMID: 15998607; PMCID: PMC1550641.
    59. Kaufman NK, Rohde P, Seeley JR, Clarke GN, Stice E. Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. J Consult Clin Psychol. 2005 Feb; 73(1):38-46. PMID: 15709830.
      View in: PubMed
    60. Hinshaw SP, Hoagwood K, Jensen PS, Kratochvil C, Bickman L, Clarke G, Abikoff HB, Atkins M, Vitiello B. AACAP 2001 research forum: challenges and recommendations regarding recruitment and retention of participants in research investigations. J Am Acad Child Adolesc Psychiatry. 2004 Aug; 43(8):1037-45. PMID: 15266200.
      View in: PubMed
    61. March J, Kratochvil C, Clarke G, Beardslee W, Derivan A, Emslie G, Green EP, Heiligenstein J, Hinshaw S, Hoagwood K, Jensen P, Lavori P, Leonard H, McNulty J, Michaels MA, Mossholder A, Osher T, Petti T, Prentice E, Vitiello B, Wells K. AACAP 2002 research forum: placebo and alternatives to placebo in randomized controlled trials in pediatric psychopharmacology. J Am Acad Child Adolesc Psychiatry. 2004 Aug; 43(8):1046-56. PMID: 15266201.
      View in: PubMed
    62. Rohde P, Clarke GN, Mace DE, Jorgensen JS, Seeley JR. An efficacy/effectiveness study of cognitive-behavioral treatment for adolescents with comorbid major depression and conduct disorder. J Am Acad Child Adolesc Psychiatry. 2004 Jun; 43(6):660-8. PMID: 15167082.
      View in: PubMed
    63. Treatment for Adolescents With Depression Study (TADS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry. 2003 May; 42(5):531-42. PMID: 12707557.
      View in: PubMed
    64. Clarke G, Reid E, Eubanks D, O'Connor E, DeBar LL, Kelleher C, Lynch F, Nunley S. Overcoming depression on the Internet (ODIN): a randomized controlled trial of an Internet depression skills intervention program. J Med Internet Res. 2002 Dec; 4(3):E14. PMID: 12554545; PMCID: PMC1761939.
    65. Hollon SD, Muñoz RF, Barlow DH, Beardslee WR, Bell CC, Bernal G, Clarke GN, Franciosi LP, Kazdin AE, Kohn L, Linehan MM, Markowitz JC, Miklowitz DJ, Persons JB, Niederehe G, Sommers D. Psychosocial intervention development for the prevention and treatment of depression: promoting innovation and increasing access. Biol Psychiatry. 2002 Sep 15; 52(6):610-30. PMID: 12361671.
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    66. Clarke GN, Hornbrook M, Lynch F, Polen M, Gale J, O'Connor E, Seeley JR, Debar L. Group cognitive-behavioral treatment for depressed adolescent offspring of depressed parents in a health maintenance organization. J Am Acad Child Adolesc Psychiatry. 2002 Mar; 41(3):305-13. PMID: 11886025.
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    67. Clarke GN, Hornbrook M, Lynch F, Polen M, Gale J, Beardslee W, O'Connor E, Seeley J. A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Arch Gen Psychiatry. 2001 Dec; 58(12):1127-34. PMID: 11735841.
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    68. Dierker LC, Albano AM, Clarke GN, Heimberg RG, Kendall PC, Merikangas KR, Lewinsohn PM, Offord DR, Kessler R, Kupfer DJ. Screening for anxiety and depression in early adolescence. J Am Acad Child Adolesc Psychiatry. 2001 Aug; 40(8):929-36. PMID: 11501693.
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    69. Keller MB, Ryan ND, Strober M, Klein RG, Kutcher SP, Birmaher B, Hagino OR, Koplewicz H, Carlson GA, Clarke GN, Emslie GJ, Feinberg D, Geller B, Kusumakar V, Papatheodorou G, Sack WH, Sweeney M, Wagner KD, Weller EB, Winters NC, Oakes R, McCafferty JP. Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry. 2001 Jul; 40(7):762-72. PMID: 11437014.
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    70. Rohde P, Clarke GN, Lewinsohn PM, Seeley JR, Kaufman NK. Impact of comorbidity on a cognitive-behavioral group treatment for adolescent depression. J Am Acad Child Adolesc Psychiatry. 2001 Jul; 40(7):795-802. PMID: 11437018.
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    71. DeBar LL, Clarke GN, O'Connor E, Nichols GA. Treated prevalence, incidence, and pharmacotherapy of child and adolescent mood disorders in an HMO. Ment Health Serv Res. 2001 Jun; 3(2):73-89. PMID: 12109840.
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    72. MacKinnon DP, Goldberg L, Clarke GN, Elliot DL, Cheong J, Lapin A, Moe EL, Krull JL. Mediating mechanisms in a program to reduce intentions to use anabolic steroids and improve exercise self-efficacy and dietary behavior. Prev Sci. 2001 Mar; 2(1):15-28. PMID: 11519372.
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    73. Mundt JC, Clarke GN, Burroughs D, Brenneman DO, Griest JH. Effectiveness of antidepressant pharmacotherapy: the impact of medication compliance and patient education. Depress Anxiety. 2001; 13(1):1-10. PMID: 11233454.
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    74. Clarke GN, Herinckx HA, Kinney RF, Paulson RI, Cutler DL, Lewis K, Oxman E. Psychiatric hospitalizations, arrests, emergency room visits, and homelessness of clients with serious and persistent mental illness: findings from a randomized trial of two ACT programs vs. usual care. Ment Health Serv Res. 2000 Sep; 2(3):155-64. PMID: 11256724.
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    75. Goldberg L, MacKinnon DP, Elliot DL, Moe EL, Clarke G, Cheong J. The adolescents training and learning to avoid steroids program: preventing drug use and promoting health behaviors. Arch Pediatr Adolesc Med. 2000 Apr; 154(4):332-8. PMID: 10768668.
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    76. Paulson R, Herinckx H, Demmler J, Clarke G, Cutler D, Birecree E. Comparing practice patterns of consumer and non-consumer mental health service providers. Community Ment Health J. 1999 Jun; 35(3):251-69. PMID: 10401895.
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    77. Lewinsohn PM, Clarke GN. Psychosocial treatments for adolescent depression. Clin Psychol Rev. 1999 Apr; 19(3):329-42. PMID: 10097874.
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    78. Clarke GN, Rohde P, Lewinsohn PM, Hops H, Seeley JR. Cognitive-behavioral treatment of adolescent depression: efficacy of acute group treatment and booster sessions. J Am Acad Child Adolesc Psychiatry. 1999 Mar; 38(3):272-9. PMID: 10087688.
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    79. Herinckx HA, Kinney RF, Clarke GN, Paulson RI. Assertive community treatment versus usual care in engaging and retaining clients with severe mental illness. Psychiatr Serv. 1997 Oct; 48(10):1297-306. PMID: 9323749.
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    80. Sack WH, Seeley JR, Clarke GN. Does PTSD transcend cultural barriers? A study from the Khmer Adolescent Refugee Project. J Am Acad Child Adolesc Psychiatry. 1997 Jan; 36(1):49-54. PMID: 9000781.
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    81. Goldberg L, Elliot D, Clarke GN, MacKinnon DP, Moe E, Zoref L, Green C, Wolf SL, Greffrath E, Miller DJ, Lapin A. Effects of a multidimensional anabolic steroid prevention intervention. The Adolescents Training and Learning to Avoid Steroids (ATLAS) Program. JAMA. 1996 Nov 20; 276(19):1555-62. PMID: 8918852.
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    82. Goldberg L, Elliot DL, Clarke GN, MacKinnon DP, Zoref L, Moe E, Green C, Wolf SL. The Adolescents Training and Learning to Avoid Steroids (ATLAS) prevention program. Background and results of a model intervention. Arch Pediatr Adolesc Med. 1996 Jul; 150(7):713-21. PMID: 8673196.
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    83. Savin D, Sack WH, Clarke GN, Meas N, Richart I. The Khmer Adolescent Project: III. A study of trauma from Thailand's Site II refugee camp. J Am Acad Child Adolesc Psychiatry. 1996 Mar; 35(3):384-91. PMID: 8714328.
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    84. Sack WH, Clarke GN, Seeley J. Multiple forms of stress in Cambodian adolescent refugees. Child Dev. 1996 Feb; 67(1):107-16. PMID: 8605822.
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    85. Hoberman HM, Clarke GN, Saunders SM. Psychosocial interventions for adolescent depression: issues, evidence, and future directions. Prog Behav Modif. 1996; 30:25-73. PMID: 7567676.
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    86. Clarke GN. Improving the transition from basic efficacy research to effectiveness studies: methodological issues and procedures. J Consult Clin Psychol. 1995 Oct; 63(5):718-25. PMID: 7593864.
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    87. Sack WH, Clarke GN, Seeley J. Posttraumatic stress disorder across two generations of Cambodian refugees. J Am Acad Child Adolesc Psychiatry. 1995 Sep; 34(9):1160-6. PMID: 7559310.
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    88. Sack WH, Clarke GN, Kinney R, Belestos G, Him C, Seeley J. The Khmer Adolescent Project. II: Functional capacities in two generations of Cambodian refugees. J Nerv Ment Dis. 1995 Mar; 183(3):177-81. PMID: 7891065.
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    89. Clarke GN, Hawkins W, Murphy M, Sheeber LB, Lewinsohn PM, Seeley JR. Targeted prevention of unipolar depressive disorder in an at-risk sample of high school adolescents: a randomized trial of a group cognitive intervention. J Am Acad Child Adolesc Psychiatry. 1995 Mar; 34(3):312-21. PMID: 7896672.
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    90. Sack WH, McSharry S, Clarke GN, Kinney R, Seeley J, Lewinsohn P. The Khmer Adolescent Project. I. Epidemiologic findings in two generations of Cambodian refugees. J Nerv Ment Dis. 1994 Jul; 182(7):387-95. PMID: 8021638.
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    91. Lewinsohn PM, Clarke GN, Seeley JR, Rohde P. Major depression in community adolescents: age at onset, episode duration, and time to recurrence. J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug; 33(6):809-18. PMID: 7598758.
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    92. Clarke GN, Sack WH, Ben R, Lanham K, Him C. English language skills in a group of previously traumatized Khmer adolescent refugees. J Nerv Ment Dis. 1993 Jul; 181(7):454-6. PMID: 8320549.
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    93. Gonzales LR, Lewinsohn PM, Clarke GN. Longitudinal follow-up of unipolar depressives: an investigation of predictors of relapse. J Consult Clin Psychol. 1985 Aug; 53(4):461-9. PMID: 4031201.
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