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Eric Larson, MD, MPH, MACP

TitleSenior Investigator
InstitutionKaiser Permanente Washington
DepartmentHealth Research Institute
ORCID ORCID Icon0000-0003-1108-6164 Additional info
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    Other Positions
    TitleExecutive Director
    InstitutionKaiser Permanente Washington
    DepartmentHealth Research Institute

    TitleVice President for Research and Health Care Innovation
    InstitutionKaiser Foundation Health Plan of Washington


    Collapse Overview 
    Collapse overview
    Eric B. Larson, MD, MPH, is executive director of Kaiser Permanente Washington Health Research Institute (KPWHRI) and vice president for research and health care innovation at Kaiser Foundation Health Plan of Washington. A general internist, Dr. Larson is a national leader in geriatrics, health services, and clinical research and has been an elected member of the National Academy of Medicine since 2007.

    Dr. Larson pursues an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Kaiser Permanente Washington and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. Among ACT’s many groundbreaking findings:

    - Regular exercise is linked to reduced risk of dementia, Alzheimer's disease, and declines in how well people think.
    - Use of larger amounts of common medications that have strong anticholinergic side effects is linked to higher risks for developing dementia, including Alzheimer’s disease.
    - Risk for dementia in old age can be linked to early life factors, such as socioeconomic status, education, and mid-life vascular risk factors.
    - Risk for dementia is also tied to blood sugar levels, even without diabetes.

    With colleagues from Duke and Harvard, , Dr. Larson started and now helps lead the National Institutes of Health (NIH) Health Care Systems Research Collaboratory. The Collaboratory sponsors pragmatic clinical trials and aims to improve the way clinical trials are conducted so that patients and care providers have access to the best available clinical evidence for decision-making. Dr. Larson is also the principal investigator for the Electronic Medical Records and Genomics (eMERGE) project at KPWHRI and the UW. The goal of eMERGE research is to better understand the genomic basis of disease to tailor medical care to individual patients based on their genomic differences.

    Dr. Larson has written or co-authored more than a dozen books, including 2017’s Enlightened Aging: Building Resilience for Long, Active Life, which draws from his decades of work as a physician and the leader of the ACT study. He has also published more than 500 peer-reviewed scientific papers.

    Dr. Larson maintains a small but long-standing internal medicine practice. He served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010.

    Collapse Research 
    Collapse research activities and funding
    U01AG006781     (LARSON, ERIC B)Sep 30, 1986 - Apr 30, 2020
    NIH/NIA
    Alzheimer's Disease Patient Registry (ADPR/ACT)
    Role: Principal Investigator

    R03HS006006     (LARSON, ERIC B)Jan 1, 1988 - Jun 30, 1990
    AHRQ
    SINGLE PATIENT RANDOMIZED CLINICAL TRIAL SERVICE
    Role: Principal Investigator

    T32DK007627     (LARSON, ERIC B)Jul 1, 1988 - Jun 30, 1993
    NIH/NIDDK
    NATIONAL RESEARCH SERVICE AWARD IN PRIMARY CARE MEDICINE
    Role: Principal Investigator

    T32PE010002     (LARSON, ERIC B)Jul 1, 1988 - Jun 30, 1998
    HRSA/BHP
    NATIONAL RESEARCH SERVICE AWARD
    Role: Principal Investigator

    R01AG009769     (LARSON, ERIC B)May 1, 1991 - Apr 30, 2003
    NIH/NIA
    EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
    Role: Principal Investigator

    N01HC045216     (LARSON, ERIC B)Sep 30, 2004 - Sep 29, 2007
    NIH/NHLBI
    Re-Engineering the Clinical Research Enterprise
    Role: Principal Investigator

    U01HG004610     (LARSON, ERIC B)Sep 27, 2007 - Aug 14, 2011
    NIH/NHGRI
    Development and Use of Network Infrastructure for High-Throughput GWA Studies
    Role: Principal Investigator

    U01HG006375     (LARSON, ERIC B)Aug 15, 2011 - Jul 31, 2015
    NIH/NHGRI
    Genetic Discovery and Application in a Clinical Setting Continuing a Partnership
    Role: Principal Investigator

    U01HG008657     (LARSON, ERIC B)Sep 1, 2015 - May 31, 2019
    NIH/NHGRI
    The Electronic Medical Records and Genomics (eMERGE) Network, Phase III
    Role: Principal Investigator

    RF1AG053959     (MONTINE, THOMAS J)Aug 15, 2016 - Jun 30, 2021
    NIH/NIA
    Molecular Phenotyping in Alzheimer's Disease
    Role: Co-Principal Investigator

    R13AG057087     (LARSON, ERIC B)May 12, 2017 - Apr 30, 2020
    NIH/NIA
    The ACT annual symposium: a living, learning, national collaboratory to advance Alzheimer's disease and brain aging research
    Role: Principal Investigator

    R01AG057508     (YAFFE, KRISTINE)Sep 15, 2017 - Apr 30, 2021
    NIH/NIA
    Multidomain Alzheimers Risk Reduction Study (MARRS) Pilot
    Role: Co-Principal Investigator

    R01AG056326     (MACDONALD, CHRISTINE L)Aug 1, 2018 - Apr 30, 2023
    NIH/NIA
    Reclaiming and Revitalizing ACT Neuroimaging Records
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, Crane PK. Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry. 2018 Dec 04. PMID: 30514930.
      View in: PubMed
    2. Yaffe K, Barnes DE, Rosenberg D, Dublin S, Kaup AR, Ludman EJ, Vittinghoff E, Peltz CB, Renz AD, Adams KJ, Larson EB. Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol. J Alzheimers Dis. 2018 Nov 23. PMID: 30475764.
      View in: PubMed
    3. Hall TO, Stanaway IB, Carrell DS, Carroll RJ, Denny JC, Hakonarson H, Larson EB, Mentch FD, Peissig PL, Pendergrass SA, Rosenthal EA, Jarvik GP, Crosslin DR. Unfolding of hidden white blood cell count phenotypes for gene discovery using latent class mixed modeling. Genes Immun. 2018 Nov 21. PMID: 30459343.
      View in: PubMed
    4. Marcum ZA, Walker R, Bobb JF, Sin MK, Gray SL, Bowen JD, McCormick W, McCurry SM, Crane PK, Larson EB. Serum Cholesterol and Incident Alzheimer's Disease: Findings from the Adult Changes in Thought Study. J Am Geriatr Soc. 2018 Oct 05. PMID: 30289959.
      View in: PubMed
    5. Heath L, Gray SL, Boudreau DM, Thummel K, Edwards KL, Fullerton SM, Crane PK, Larson EB. Cumulative Antidepressant Use and Risk of Dementia in a Prospective Cohort Study. J Am Geriatr Soc. 2018 Oct; 66(10):1948-1955. PMID: 30221747.
      View in: PubMed
    6. Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Weiss ST, Wang TJ, Stein CM, Denny JC, Roden DM. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nat Commun. 2018 08 30; 9(1):3522. PMID: 30166544.
      View in: PubMed
    7. Lee CS, Larson EB, Gibbons LE, Lee AY, McCurry SM, Bowen JD, McCormick WC, Crane PK. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. Alzheimers Dement. 2018 Aug 02. PMID: 30098888.
      View in: PubMed
    8. Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018 Aug 01; 75(8):989-998. PMID: 29801024.
      View in: PubMed
    9. Williams JL, Chung WK, Fedotov A, Kiryluk K, Weng C, Connolly JJ, Harr M, Hakonarson H, Leppig KA, Larson EB, Jarvik GP, Veenstra DL, Hoell C, Smith ME, Holm IA, Peterson JF, Williams MS. Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs. Healthcare (Basel). 2018 Jul 13; 6(3). PMID: 30011878.
      View in: PubMed
    10. Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018 Dec; 136(6):857-872. PMID: 29967939.
      View in: PubMed
    11. Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018 06 22; 360(6395). PMID: 29930110.
      View in: PubMed
    12. Edlow BL, Keene CD, Perl DP, Iacono D, Folkerth RD, Stewart W, Mac Donald CL, Augustinack J, Diaz-Arrastia R, Estrada C, Flannery E, Gordon WA, Grabowski TJ, Hansen K, Hoffman J, Kroenke C, Larson EB, Lee P, Mareyam A, McNab JA, McPhee J, Moreau AL, Renz A, Richmire K, Stevens A, Tang CY, Tirrell LS, Trittschuh EH, van der Kouwe A, Varjabedian A, Wald LL, Wu O, Yendiki A, Young L, Zöllei L, Fischl B, Crane PK, Dams-O'Connor K. Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project. J Neurotrauma. 2018 Jul 15; 35(14):1604-1619. PMID: 29421973.
      View in: PubMed
    13. Rose SE, Frankowski H, Knupp A, Berry BJ, Martinez R, Dinh SQ, Bruner LT, Willis SL, Crane PK, Larson EB, Grabowski T, Darvas M, Keene CD, Young JE. Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds. J Neuropathol Exp Neurol. 2018 May 01; 77(5):353-360. PMID: 29474672.
      View in: PubMed
    14. Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heijer M, Hollander AI, Ruijter HM, Dennis JG, Denny JC, Angelantonio E, Drenos F, Du M, Dubé MP, Dunning AM, Easton DF, Edwards TL, Ellinghaus D, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Farooqi IS, Faul JD, Fauser S, Feng S, Ferrannini E, Ferrieres J, Florez JC, Ford I, Fornage M, Franco OH, Franke A, Franks PW, Friedrich N, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Gibson J, Giedraitis V, Gjesing AP, Gordon-Larsen P, Gorski M, Grabe HJ, Grant SFA, Grarup N, Griffiths HL, Grove ML, Gudnason V, Gustafsson S, Haessler J, Hakonarson H, Hammerschlag AR, Hansen T, Harris KM, Harris TB, Hattersley AT, Have CT, Hayward C, He L, Heard-Costa NL, Heath AC, Heid IM, Helgeland Ø, Hernesniemi J, Hewitt AW, Holmen OL, Hovingh GK, Howson JMM, Hu Y, Huang PL, Huffman JE, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jia Y, Johansson S, Jørgensen ME, Jørgensen T, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SLR, Karpe F, Kathiresan S, Kee F, Kiemeney LA, Kim E, Kitajima H, Komulainen P, Kooner JS, Kooperberg C, Korhonen T, Kovacs P, Kuivaniemi H, Kutalik Z, Kuulasmaa K, Kuusisto J, Laakso M, Lakka TA, Lamparter D, Lange EM, Lange LA, Langenberg C, Larson EB, Lee NR, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin KH, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu CT, Liu DJ, Liu Y, Lo KS, Lophatananon A, Lotery AJ, Loukola A, Luan J, Lubitz SA, Lyytikäinen LP, Männistö S, Marenne G, Mazul AL, McCarthy MI, McKean-Cowdin R, Medland SE, Meidtner K, Milani L, Mistry V, Mitchell P, Mohlke KL, Moilanen L, Moitry M, Montgomery GW, Mook-Kanamori DO, Moore C, Mori TA, Morris AD, Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Narisu N, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Nyholt DR, O'Connel JR, O'Donoghue ML, Olde Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CNA, Palmer ND, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JRB, Pers TH, Person TN, Peters A, Petersen ERB, Peyser PA, Pirie A, Polasek O, Polderman TJ, Puolijoki H, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Renström F, Rheinberger M, Ridker PM, Rioux JD, Rivas MA, Roberts DJ, Robertson NR, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sapkota Y, Sattar N, Schoen RE, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah SH, Sheu WH, Sim X, Slater AJ, Small KS, Smith AV, Southam L, Spector TD, Speliotes EK, Starr JM, Stefansson K, Steinthorsdottir V, Stirrups KE, Strauch K, Stringham HM, Stumvoll M, Sun L, Surendran P, Swift AJ, Tada H, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorleifsson G, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Uusitupa M, Laan SW, Duijn CM, Leeuwen N, van Setten J, et al. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 May; 50(5):765-766. PMID: 29549329.
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    219. Green BB, Cook AJ, Ralston JD, Fishman PA, Catz SL, Carlson J, Carrell D, Tyll L, Larson EB, Thompson RS. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA. 2008 Jun 25; 299(24):2857-67. PMID: 18577730; PMCID: PMC2715866.
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    229. Berke EM, Gottlieb LM, Moudon AV, Larson EB. Protective association between neighborhood walkability and depression in older men. J Am Geriatr Soc. 2007 Apr; 55(4):526-33. PMID: 17397430.
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    237. Lemaitre RN, Weiss NS, Smith NL, Psaty BM, Lumley T, Larson EB, Heckbert SR. Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke. Arch Intern Med. 2006 Feb 27; 166(4):399-404. PMID: 16505258.
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    239. Jackson LA, Nelson JC, Benson P, Neuzil KM, Reid RJ, Psaty BM, Heckbert SR, Larson EB, Weiss NS. Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol. 2006 Apr; 35(2):345-52. PMID: 16368724.
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    259. Tencer AF, Koepsell TD, Wolf ME, Frankenfeld CL, Buchner DM, Kukull WA, LaCroix AZ, Larson EB, Tautvydas M. Biomechanical properties of shoes and risk of falls in older adults. J Am Geriatr Soc. 2004 Nov; 52(11):1840-6. PMID: 15507060.
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    260. Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, Larson EB, Rosendaal FR, Psaty BM. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA. 2004 Oct 06; 292(13):1581-7. PMID: 15467060.
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    261. Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D. Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study. J Am Geriatr Soc. 2004 Sep; 52(9):1442-8. PMID: 15341544; PMCID: PMC1487184.
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    263. Showstack J, Lurie N, Larson EB, Rothman AA, Hassmiller SB. The future of primary care. AHIP Cover. 2004 May-Jun; 45(3):55-6, 58, 60. PMID: 15318426.
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    267. Langa KM, Larson EB, Wallace RB, Fendrick AM, Foster NL, Kabeto MU, Weir DR, Willis RJ, Herzog AR. Out-of-pocket health care expenditures among older Americans with dementia. Alzheimer Dis Assoc Disord. 2004 Apr-Jun; 18(2):90-8. PMID: 15249853.
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    268. Gendo K, Larson EB. Evidence-based diagnostic strategies for evaluating suspected allergic rhinitis. Ann Intern Med. 2004 Feb 17; 140(4):278-89. PMID: 14970151.
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    273. Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, Kukull WA, LaCroix AZ, McCormick W, Larson EB. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003 Oct 15; 290(15):2015-22. PMID: 14559955.
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    274. Larson EB. Review: fair evidence supports several tests in investigating fever of unknown origin. ACP J Club. 2003 Sep-Oct; 139(2):49. PMID: 12954041.
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    276. LaVallie DL, Gabbe SG, Grossman DC, Larson EB, Baldwin LM, Andrilla CH. Birth outcomes among American Indian/Alaska Native women with diabetes in pregnancy. J Reprod Med. 2003 Aug; 48(8):610-6. PMID: 12971141.
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    319. Graves AB, Rosner D, Echeverria D, Mortimer JA, Larson EB. Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease. Occup Environ Med. 1998 Sep; 55(9):627-33. PMID: 9861186; PMCID: PMC1757634.
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    328. Every NR, Parsons LS, Fihn SD, Larson EB, Maynard C, Hallstrom AP, Martin JS, Weaver WD. Long-term outcome in acute myocardial infarction patients admitted to hospitals with and without on-site cardiac catheterization facilities. MITI Investigators. Myocardial Infarction Triage and Intervention. Circulation. 1997 Sep 16; 96(6):1770-5. PMID: 9323060.
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    344. Malter AD, Larson EB, Urban N, Deyo RA. Cost-effectiveness of lumbar discectomy for the treatment of herniated intervertebral disc. Spine (Phila Pa 1976). 1996 May 01; 21(9):1048-54; discussion 1055. PMID: 8724089.
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    348. Larson EB, Kukull WA. Prevention of Alzheimer disease: a perspective based on successes in the prevention of other chronic diseases. Alzheimer Dis Assoc Disord. 1996; 10 Suppl 1:9-12. PMID: 8876781.
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    349. Speck CE, Kukull WA, Brenner DE, Bowen JD, McCormick WC, Teri L, Pfanschmidt ML, Thompson JD, Larson EB. History of depression as a risk factor for Alzheimer's disease. Epidemiology. 1995 Jul; 6(4):366-9. PMID: 7548342.
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    350. Snowden MB, Bowen JD, Hughes J, Larson EB. Study of Alzheimer's dementia patients with parkinsonian features. J Geriatr Psychiatry Neurol. 1995 Jul; 8(3):154-8. PMID: 7576038.
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    351. Kukull WA, Larson EB, Bowen JD, McCormick WC, Teri L, Pfanschmidt ML, Thompson JD, O'Meara ES, Brenner DE, van Belle G. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. Am J Epidemiol. 1995 Jun 01; 141(11):1059-71; discussion 1072-9. PMID: 7771442.
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    352. Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 1995 Jun; 45(6):1092-6. PMID: 7783869.
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    353. McCormick WC, Kukull WA, van Belle G, Bowen JD, Teri L, Larson EB. The effect of diagnosing Alzheimer's disease on frequency of physician visits: a case-control study. J Gen Intern Med. 1995 Apr; 10(4):187-93. PMID: 7790979.
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    354. Bradley KA, Curry SJ, Koepsell TD, Larson EB. Primary and secondary prevention of alcohol problems: U.S. internist attitudes and practices. J Gen Intern Med. 1995 Feb; 10(2):67-72. PMID: 7730941.
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    355. Alexander EM, Wagner EH, Buchner DM, Cain KC, Larson EB. Do surgical brain lesions present as isolated dementia? A population-based study. J Am Geriatr Soc. 1995 Feb; 43(2):138-43. PMID: 7836637.
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    356. Fuh JL, Teng EL, Lin KN, Larson EB, Wang SJ, Liu CY, Chou P, Kuo BI, Liu HC. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening tool for dementia for a predominantly illiterate Chinese population. Neurology. 1995 Jan; 45(1):92-6. PMID: 7824143.
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    357. Teri L, McCurry SM, Edland SD, Kukull WA, Larson EB. Cognitive decline in Alzheimer's disease: a longitudinal investigation of risk factors for accelerated decline. J Gerontol A Biol Sci Med Sci. 1995 Jan; 50A(1):M49-55. PMID: 7814789.
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    358. Kukull WA, Larson EB, Teri L, Bowen J, McCormick W, Pfanschmidt ML. The Mini-Mental State Examination score and the clinical diagnosis of dementia. J Clin Epidemiol. 1994 Sep; 47(9):1061-7. PMID: 7730909.
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    359. Liu HC, Chou P, Lin KN, Wang SJ, Fuh JL, Lin HC, Liu CY, Wu GS, Larson EB, White LR, et al. Assessing cognitive abilities and dementia in a predominantly illiterate population of older individuals in Kinmen. Psychol Med. 1994 Aug; 24(3):763-70. PMID: 7991758.
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    360. Brenner DE, Kukull WA, Stergachis A, van Belle G, Bowen JD, McCormick WC, Teri L, Larson EB. Postmenopausal estrogen replacement therapy and the risk of Alzheimer's disease: a population-based case-control study. Am J Epidemiol. 1994 Aug 01; 140(3):262-7. PMID: 8030629.
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    361. Kukull WA, Brenner DE, Speck CE, Nochlin D, Bowen J, McCormick W, Teri L, Pfanschmidt ML, Larson EB. Causes of death associated with Alzheimer disease: variation by level of cognitive impairment before death. J Am Geriatr Soc. 1994 Jul; 42(7):723-6. PMID: 8014346.
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    362. Kent DL, Haynor DR, Longstreth WT, Larson EB. The clinical efficacy of magnetic resonance imaging in neuroimaging. Ann Intern Med. 1994 May 15; 120(10):856-71. PMID: 7818632.
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    363. Bradley KA, Larson EB. Training physicians to help patients who drink too much. J Gen Intern Med. 1994 May; 9(5):296-8. PMID: 8046535.
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    364. McCormick WC, Kukull WA, van Belle G, Bowen JD, Teri L, Larson EB. Symptom patterns and comorbidity in the early stages of Alzheimer's disease. J Am Geriatr Soc. 1994 May; 42(5):517-21. PMID: 8176147.
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    365. Hinds TR, Kukull WA, Van Belle G, Schellenberg GD, Villacres EC, Larson EB. Relationship between serum alpha 1-antichymotrypsin and Alzheimer's disease. Neurobiol Aging. 1994 Jan-Feb; 15(1):21-7. PMID: 8159260.
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    366. Graves AB, Larson EB, White LR, Teng EL, Homma A. Opportunities and challenges in international collaborative epidemiologic research of dementia and its subtypes: studies between Japan and the U.S. Int Psychogeriatr. 1994; 6(2):209-23. PMID: 7865708.
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    367. Bradley KA, Donovan DM, Larson EB. How much is too much? Advising patients about safe levels of alcohol consumption. Arch Intern Med. 1993 Dec 27; 153(24):2734-40. PMID: 8257248.
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    368. Every NR, Larson EB, Litwin PE, Maynard C, Fihn SD, Eisenberg MS, Hallstrom AP, Martin JS, Weaver WD. The association between on-site cardiac catheterization facilities and the use of coronary angiography after acute myocardial infarction. Myocardial Infarction Triage and Intervention Project Investigators. N Engl J Med. 1993 Aug 19; 329(8):546-51. PMID: 8336755.
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    369. Atkins D, Psaty BM, Koepsell TD, Longstreth WT, Larson EB. Cholesterol reduction and the risk for stroke in men. A meta-analysis of randomized, controlled trials. Ann Intern Med. 1993 Jul 15; 119(2):136-45. PMID: 8305001.
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    370. Bowen JD, Larson EB. Drug-induced cognitive impairment. Defining the problem and finding solutions. Drugs Aging. 1993 Jul-Aug; 3(4):349-57. PMID: 8369594.
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    371. Larson EB. Adverse drug effects: the harder we look, the more we find. J Gen Intern Med. 1993 Jun; 8(6):342-3. PMID: 8320580.
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    372. Grossmann A, Kukull WA, Jinneman JC, Bird TD, Villacres EC, Larson EB, Rabinovitch PS. Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome. Neurobiol Aging. 1993 Mar-Apr; 14(2):177-85. PMID: 8098135.
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    373. Brenner DE, Kukull WA, van Belle G, Bowen JD, McCormick WC, Teri L, Larson EB. Relationship between cigarette smoking and Alzheimer's disease in a population-based case-control study. Neurology. 1993 Feb; 43(2):293-300. PMID: 8437692.
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    374. Larson EB. Illnesses causing dementia in the very elderly. N Engl J Med. 1993 Jan 21; 328(3):203-5. PMID: 8417387.
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    375. Weingarten S, Kleinman M, Elperin L, Larson EB. The effectiveness of cerebral imaging in the diagnosis of chronic headache. Arch Intern Med. 1992 Dec; 152(12):2457-62. PMID: 1456857.
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    376. Elward KS, Wagner EH, Larson EB. Participation by sedentary elderly persons in an exercise promotion session. Fam Med. 1992 Nov-Dec; 24(8):607-12. PMID: 1426730.
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    377. Logsdon RG, Teri L, Larson EB. Driving and Alzheimer's disease. J Gen Intern Med. 1992 Nov-Dec; 7(6):583-8. PMID: 1453241.
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    378. Atkins D, Larson EB. X-rays for sinusitis: a matter of which or when? J Gen Intern Med. 1992 Sep-Oct; 7(5):566. PMID: 1403217.
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    379. Larson EB, Ramsbottom-Lucier M. Talking to patients. J Gen Intern Med. 1992 Jul-Aug; 7(4):464-5. PMID: 1506956.
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    380. Haynes RB, Sandler RS, Larson EB, Pater JL, Yatsu FM. A critical appraisal of ticlopidine, a new antiplatelet agent. Effectiveness and clinical indications for prophylaxis of atherosclerotic events. Arch Intern Med. 1992 Jul; 152(7):1376-80. PMID: 1627017.
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    381. Kent DL, Haynor DR, Larson EB, Deyo RA. Diagnosis of lumbar spinal stenosis in adults: a metaanalysis of the accuracy of CT, MR, and myelography. AJR Am J Roentgenol. 1992 May; 158(5):1135-44. PMID: 1533084.
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    382. Larson EB. Academic mentorship: an important ingredient for our survival. J Gen Intern Med. 1992 Mar-Apr; 7(2):255. PMID: 1487779.
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    383. Welch HG, Walsh JS, Larson EB. The cost of institutional care in Alzheimer's disease: nursing home and hospital use in a prospective cohort. J Am Geriatr Soc. 1992 Mar; 40(3):221-4. PMID: 1538039.
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    384. Kukull WA, Hinds TR, Schellenberg GD, van Belle G, Larson EB. Increased platelet membrane fluidity as a diagnostic marker for Alzheimer's disease: a test in population-based cases and controls. Neurology. 1992 Mar; 42(3 Pt 1):607-14. PMID: 1549223.
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    385. Kent DL, Larson EB. Disease, level of impact, and quality of research methods. Three dimensions of clinical efficacy assessment applied to magnetic resonance imaging. Invest Radiol. 1992 Mar; 27(3):245-54. PMID: 1551777.
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    386. Elward K, Larson EB. Benefits of exercise for older adults. A review of existing evidence and current recommendations for the general population. Clin Geriatr Med. 1992 Feb; 8(1):35-50. PMID: 1576579.
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    387. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: dementia and Alzheimer's disease. Annu Rev Public Health. 1992; 13:431-49. PMID: 1599598.
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    388. Buchner DM, Beresford SA, Larson EB, LaCroix AZ, Wagner EH. Effects of physical activity on health status in older adults. II. Intervention studies. Annu Rev Public Health. 1992; 13:469-88. PMID: 1599599.
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    389. Wagner EH, LaCroix AZ, Buchner DM, Larson EB. Effects of physical activity on health status in older adults. I: Observational studies. Annu Rev Public Health. 1992; 13:451-68. PMID: 1534661.
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    390. Schellenberg GD, Anderson L, O'dahl S, Wisjman EM, Sadovnick AD, Ball MJ, Larson EB, Kukull WA, Martin GM, Roses AD, et al. APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease. Am J Hum Genet. 1991 Sep; 49(3):511-7. PMID: 1679288; PMCID: PMC1683125.
    391. Ramsey PG, Carline JD, Inui TS, Larson EB, LoGerfo JP, Norcini JJ, Wenrich MD. Changes over time in the knowledge base of practicing internists. JAMA. 1991 Aug 28; 266(8):1103-7. PMID: 1865543.
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    392. Larson EB. Geriatric medicine. JAMA. 1991 Jun 19; 265(23):3125-6. PMID: 2041122.
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    393. Edwards JK, Larson EB, Hughes JP, Kukull WA. Are there clinical and epidemiological differences between familial and non-familial Alzheimer's disease? J Am Geriatr Soc. 1991 May; 39(5):477-83. PMID: 2022799.
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    394. Uhlmann RF, Larson EB, Koepsell TD, Rees TS, Duckert LG. Visual impairment and cognitive dysfunction in Alzheimer's disease. J Gen Intern Med. 1991 Mar-Apr; 6(2):126-32. PMID: 2023019.
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    395. McCormick WC, Larson EB. Pragmatism and probabilities in dementia. Hosp Pract (Off Ed). 1990 Dec 15; 25(12):93-100, 103-6, 113-4. PMID: 2123215.
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    396. Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB, Raskind M. A case-control study of Alzheimer's disease. Ann Neurol. 1990 Dec; 28(6):766-74. PMID: 2285263.
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    397. Larson EB, Kukull WA, Teri L, McCormick W, Pfanschmidt M, van Belle G, Sumi M. University of Washington Alzheimer's Disease Patient Registry (ADPR): 1987-1988. Aging (Milano). 1990 Dec; 2(4):404-8. PMID: 2094380.
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    398. Walsh JS, Welch HG, Larson EB. Survival of outpatients with Alzheimer-type dementia. Ann Intern Med. 1990 Sep 15; 113(6):429-34. PMID: 2386336.
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    399. Kukull WA, Larson EB, Reifler BV, Lampe TH, Yerby MS, Hughes JP. The validity of 3 clinical diagnostic criteria for Alzheimer's disease. Neurology. 1990 Sep; 40(9):1364-9. PMID: 2392219.
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    400. Larson EB, Hughes JP, Kukull WA. New data gathering, instrument selection, and evaluation of existing information for determining entry. Aging (Milano). 1990 Jun; 2(2):215-22. PMID: 2095863.
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    401. Teri L, Hughes JP, Larson EB. Cognitive deterioration in Alzheimer's disease: behavioral and health factors. J Gerontol. 1990 Mar; 45(2):P58-63. PMID: 2313049.
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    402. Larson EB. Medical technologies: restraint or discretion? J Gen Intern Med. 1990 Mar-Apr; 5(2):178-9. PMID: 2313409.
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    403. Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB, Raskind M. The association between head trauma and Alzheimer's disease. Am J Epidemiol. 1990 Mar; 131(3):491-501. PMID: 2405648.
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    404. Kukull WA, Larson EB, Reifler BV, Lampe TH, Yerby M, Hughes J. Interrater reliability of Alzheimer's disease diagnosis. Neurology. 1990 Feb; 40(2):257-60. PMID: 2300244.
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    405. Fihn SD, Larson EB, Friedman RH, Moskowitz MA. Ambulatory care research in the VA: present status and recommendations for the future. Acad Med. 1989 Oct; 64(10 Suppl):S35-43. PMID: 2789613.
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    406. Carline JD, Inui TS, Larson EB, LoGerfo JP, Ramsey PG. The knowledge base of certified internists. Relationships to training, practice type, and other physician characteristics. Arch Intern Med. 1989 Oct; 149(10):2311-3. PMID: 2802895.
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    407. Bowen JD, Larson EB. Understanding the dizzy patient. A challenge to primary care physicians. J Fam Pract. 1989 Jul; 29(1):30-2. PMID: 2738547.
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    408. Kukull WA, Larson EB. Distinguishing Alzheimer's disease from other dementias. Questionnaire responses of close relatives and autopsy results. J Am Geriatr Soc. 1989 Jun; 37(6):521-7. PMID: 2654258.
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    409. Ramsey PG, Carline JD, Inui TS, Larson EB, LoGerfo JP, Wenrich MD. Predictive validity of certification by the American Board of Internal Medicine. Ann Intern Med. 1989 May 01; 110(9):719-26. PMID: 2930109.
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    410. Uhlmann RF, Larson EB, Rees TS, Koepsell TD, Duckert LG. Relationship of hearing impairment to dementia and cognitive dysfunction in older adults. JAMA. 1989 Apr 07; 261(13):1916-9. PMID: 2926927.
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    411. Uhlmann RF, Teri L, Rees TS, Mozlowski KJ, Larson EB. Impact of mild to moderate hearing loss on mental status testing. Comparability of standard and written Mini-Mental State Examinations. J Am Geriatr Soc. 1989 Mar; 37(3):223-8. PMID: 2918192.
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    412. VanArsdel PP, Larson EB. Diagnostic tests for patients with suspected allergic disease. Utility and limitations. Ann Intern Med. 1989 Feb 15; 110(4):304-12. PMID: 2643916.
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    413. Hughes JP, van Belle G, Kukull W, Larson EB, Teri L. On the uses of registries for Alzheimer disease. Alzheimer Dis Assoc Disord. 1989; 3(4):205-17. PMID: 2688699.
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    414. Buchner DM, Larson EB. Transfer bias and the association of cognitive impairment with falls. J Gen Intern Med. 1988 May-Jun; 3(3):254-9. PMID: 3259981.
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    415. Kent DL, Larson EB. Diagnostic technology assessments: problems and prospects. Ann Intern Med. 1988 May; 108(5):759-61. PMID: 3358576.
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    416. Krueger DW, Larson EB. Recurrent fever of unknown origin, coma, and meningismus due to a leaking craniopharyngioma. Am J Med. 1988 Mar; 84(3 Pt 1):543-5. PMID: 3348255.
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    417. Kent DL, Larson EB. Magnetic resonance imaging of the brain and spine. Is clinical efficacy established after the first decade? Ann Intern Med. 1988 Mar; 108(3):402-24. PMID: 3277514.
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    418. Teri L, Larson EB, Reifler BV. Behavioral disturbance in dementia of the Alzheimer's type. J Am Geriatr Soc. 1988 Jan; 36(1):1-6. PMID: 3335725.
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    419. Ellsworth AJ, Larson EB, Strickland D. A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis. Am J Med. 1987 Dec; 83(6):1024-30. PMID: 3332564.
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    420. Larson EB. Competition and technology's consort. Am J Med. 1987 Aug; 83(2):340-2. PMID: 3618634.
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    421. Larson EB, Kukull WA, Buchner D, Reifler BV. Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Intern Med. 1987 Aug; 107(2):169-73. PMID: 2886086.
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    422. Nardone DA, Wallack P, Martinez-Weber C, Larson EB, Goldstein BJ, Mushlin AI. Letters to the editors. J Gen Intern Med. 1987 Jul; 2(4):288-9. PMID: 27519732.
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    423. Luthy DA, Shy KK, van Belle G, Larson EB, Hughes JP, Benedetti TJ, Brown ZA, Effer S, King JF, Stenchever MA. A randomized trial of electronic fetal monitoring in preterm labor. Obstet Gynecol. 1987 May; 69(5):687-95. PMID: 3554055.
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    424. Buchner DM, Larson EB. Falls and fractures in patients with Alzheimer-type dementia. JAMA. 1987 Mar 20; 257(11):1492-5. PMID: 3820464.
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    425. Shapiro MF, Larson EB. Funding for medical care research. J Gen Intern Med. 1987 Mar-Apr; 2(2):113-8. PMID: 3559775.
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    426. Larson EB, Bruce RA. Health benefits of exercise in an aging society. Arch Intern Med. 1987 Feb; 147(2):353-6. PMID: 3545119.
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    427. Reifler BV, Larson EB, Teri L. An outpatient geriatric psychiatry assessment and treatment service. Clin Geriatr Med. 1987 Feb; 3(1):203-9. PMID: 3815245.
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    428. Uhlmann RF, Larson EB, Buchner DM. Correlations of Mini-Mental State and modified Dementia Rating Scale to measures of transitional health status in dementia. J Gerontol. 1987 Jan; 42(1):33-6. PMID: 3794193.
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    429. Larson EB, Bruce RA. Exercise and aging. Ann Intern Med. 1986 Nov; 105(5):783-5. PMID: 3767154.
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    430. Larson EB, Buchner DM, Uhlmann RF, Reifler BV. Caring for elderly patients with dementia. Arch Intern Med. 1986 Oct; 146(10):1909-10. PMID: 3767532.
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    431. Larson EB, Reifler BV, Sumi SM, Canfield CG, Chinn NM. Diagnostic tests in the evaluation of dementia. A prospective study of 200 elderly outpatients. Arch Intern Med. 1986 Oct; 146(10):1917-22. PMID: 3767535.
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    432. Fletcher RH, Burack RC, Larson EB, Lewis CE, Noren JJ, Rabin DL, Stokes J, Scatarige CS, Reid Y. Interrelationships of general internal medicine and preventive/community medicine. Am J Prev Med. 1986 Sep-Oct; 2(5):285-9. PMID: 3453193.
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    433. Larson EB. Practice-based research in geriatrics by general internists. J Gen Intern Med. 1986 Jul-Aug; 1(4 Suppl):S42-4. PMID: 3772609.
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    434. Larson EB, Lo B, Williams ME. Evaluation and care of elderly patients with dementia. J Gen Intern Med. 1986 Mar-Apr; 1(2):116-26. PMID: 3534170.
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    435. Uhlmann RF, Larson EB, Koepsell TD. Hearing impairment and cognitive decline in senile dementia of the Alzheimer's type. J Am Geriatr Soc. 1986 Mar; 34(3):207-10. PMID: 3950288.
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    436. Larson EB, Reifler BV, Sumi SM, Canfield CG, Chinn NM. Diagnostic evaluation of 200 elderly outpatients with suspected dementia. J Gerontol. 1985 Sep; 40(5):536-43. PMID: 4031401.
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    437. Fihn SD, Larson EB, Nelp WB, Rudd TG, Gerber FH. Should single-phase radionuclide bone imaging be used in suspected osteomyelitis? J Nucl Med. 1984 Oct; 25(10):1080-8. PMID: 6481459.
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    438. Larson EB, Reifler BV, Featherstone HJ, English DR. Dementia in elderly outpatients: a prospective study. Ann Intern Med. 1984 Mar; 100(3):417-23. PMID: 6696360.
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    439. Fihn SD, Larson EB, Rudd TR, Nelp WB. Clinical use of radionuclide bone imaging in a university medical center. JAMA. 1982 Jul 23; 248(4):439-42. PMID: 7087143.
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    440. Larson EB, Mack LA, Watts B, Cromwell LD. Computed tomography in patients with psychiatric illnesses: advantage of a "rule-in" approach. Ann Intern Med. 1981 Sep; 95(3):360-4. PMID: 7271095.
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    441. Larson EB, Stratton JR, Pearlman AS. Selective use of two-dimensional echocardiography in stroke syndromes. Ann Intern Med. 1981 Jul; 95(1):112-4. PMID: 7247112.
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    442. Fihn SD, Larson EB. Relapsing Fever revisited. West J Med. 1981 Mar; 134(3):263-4. PMID: 18748834.
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    443. Fihn S, Larson EB. Tick-borne relapsing fever in the Pacific Northwest: an underdiagnosed illness? West J Med. 1980 Sep; 133(3):203-9. PMID: 7415171; PMCID: PMC1272260.
    444. Larson EB, Omenn GS, Lewis H. Diagnostic evaluation of headache. Impact of computerized tomography and cost-effectiveness. JAMA. 1980 Jan 25; 243(4):359-62. PMID: 6766193.
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