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Eric Larson, MD, MPH, MACP

TitleSenior Investigator
InstitutionKaiser Permanente Washington
DepartmentKaiser Permanente Washington Health Research Institute
Address1730 Minor Ave
Seattle WA 98101
ORCID ORCID Icon0000-0003-1108-6164 Additional info
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    Other Positions
    TitleFormer Executive Director
    InstitutionKaiser Permanente Washington
    DepartmentKaiser Permanente Washington Health Research Institute

    TitleFormer Vice President for Research and Health Care Innovation
    InstitutionKaiser Permanente Washington
    DepartmentKaiser Permanente Washington Health Research Institute


    Collapse Overview 
    Collapse overview
    Eric B. Larson, MD, MPH, is executive director of Kaiser Permanente Washington Health Research Institute (KPWHRI) and vice president for research and health care innovation at Kaiser Foundation Health Plan of Washington. A general internist, Dr. Larson is a national leader in geriatrics, health services, and clinical research and has been an elected member of the National Academy of Medicine since 2007.

    Dr. Larson pursues an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Kaiser Permanente Washington and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. Among ACT’s many groundbreaking findings:

    - Regular exercise is linked to reduced risk of dementia, Alzheimer's disease, and declines in how well people think.
    - Use of larger amounts of common medications that have strong anticholinergic side effects is linked to higher risks for developing dementia, including Alzheimer’s disease.
    - Risk for dementia in old age can be linked to early life factors, such as socioeconomic status, education, and mid-life vascular risk factors.
    - Risk for dementia is also tied to blood sugar levels, even without diabetes.

    With colleagues from Duke and Harvard, , Dr. Larson started and now helps lead the National Institutes of Health (NIH) Health Care Systems Research Collaboratory. The Collaboratory sponsors pragmatic clinical trials and aims to improve the way clinical trials are conducted so that patients and care providers have access to the best available clinical evidence for decision-making. Dr. Larson is also the principal investigator for the Electronic Medical Records and Genomics (eMERGE) project at KPWHRI and the UW. The goal of eMERGE research is to better understand the genomic basis of disease to tailor medical care to individual patients based on their genomic differences.

    Dr. Larson has written or co-authored more than a dozen books, including 2017’s Enlightened Aging: Building Resilience for Long, Active Life, which draws from his decades of work as a physician and the leader of the ACT study. He has also published more than 500 peer-reviewed scientific papers.

    Dr. Larson maintains a small but long-standing internal medicine practice. He served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010.

    Collapse Research 
    Collapse research activities and funding
    R01AG056326     (MACDONALD, CHRISTINE L)Aug 1, 2018 - Apr 30, 2023
    NIH/NIA
    Reclaiming and Revitalizing ACT Neuroimaging Records
    Role: Co-Principal Investigator

    R01AG057508     (YAFFE, KRISTINE)Sep 15, 2017 - Apr 30, 2021
    NIH/NIA
    Multidomain Alzheimers Risk Reduction Study (MARRS) Pilot
    Role: Co-Principal Investigator

    R13AG057087     (LARSON, ERIC B)May 12, 2017 - Apr 30, 2020
    NIH/NIA
    The ACT annual symposium: a living, learning, national collaboratory to advance Alzheimer's disease and brain aging research
    Role: Principal Investigator

    RF1AG053959     (MONTINE, THOMAS J)Aug 15, 2016 - Jun 30, 2021
    NIH/NIA
    Molecular Phenotyping in Alzheimer's Disease
    Role: Co-Principal Investigator

    U01HG008657     (LARSON, ERIC B)Sep 1, 2015 - May 31, 2019
    NIH/NHGRI
    The Electronic Medical Records and Genomics (eMERGE) Network, Phase III
    Role: Principal Investigator

    U01HG006375     (LARSON, ERIC B)Aug 15, 2011 - Jul 31, 2015
    NIH/NHGRI
    Genetic Discovery and Application in a Clinical Setting Continuing a Partnership
    Role: Principal Investigator

    U01HG004610     (LARSON, ERIC B)Sep 27, 2007 - Aug 14, 2011
    NIH/NHGRI
    Development and Use of Network Infrastructure for High-Throughput GWA Studies
    Role: Principal Investigator

    N01HC045216     (LARSON, ERIC B)Sep 30, 2004 - Sep 29, 2007
    NIH/NHLBI
    Re-Engineering the Clinical Research Enterprise
    Role: Principal Investigator

    R01AG009769     (LARSON, ERIC B)May 1, 1991 - Apr 30, 2003
    NIH/NIA
    EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
    Role: Principal Investigator

    T32PE010002     (LARSON, ERIC B)Jul 1, 1988 - Jun 30, 1998
    HRSA/BHP
    NATIONAL RESEARCH SERVICE AWARD
    Role: Principal Investigator

    T32DK007627     (LARSON, ERIC B)Jul 1, 1988 - Jun 30, 1993
    NIH/NIDDK
    NATIONAL RESEARCH SERVICE AWARD IN PRIMARY CARE MEDICINE
    Role: Principal Investigator

    R03HS006006     (LARSON, ERIC B)Jan 1, 1988 - Jun 30, 1990
    AHRQ
    SINGLE PATIENT RANDOMIZED CLINICAL TRIAL SERVICE
    Role: Principal Investigator

    U01AG006781     (LARSON, ERIC B)Sep 30, 1986 - Apr 30, 2020
    NIH/NIA
    Alzheimer's Disease Patient Registry (ADPR/ACT)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Barthold D, Gibbons LE, Marcum ZA, Gray SL, Dirk Keene C, Grabowski TJ, Postupna N, Larson EB, Crane PK. Alzheimer's Disease-Related Neuropathology Among Patients with Medication Treated Type 2 Diabetes in a Community-Based Autopsy Cohort. J Alzheimers Dis. 2021 Aug 14. PMID: 34420950.
      Citations:    
    2. Greenwood-Hickman MA, Walker R, Bellettiere J, LaCroix AZ, Kim B, Wing D, Richmire K, Crane PK, Larson EB, Rosenberg DE. Associations Between Perceived Neighborhood Walkability and Device-Based Physical Activity and Sedentary Behavior Patterns in Older Adults. J Aging Phys Act. 2021 Aug 13; 1-9. PMID: 34388701.
      Citations:    
    3. Shaffer RM, Blanco MN, Li G, Adar SD, Carone M, Szpiro AA, Kaufman JD, Larson TV, Larson EB, Crane PK, Sheppard L. Fine Particulate Matter and Dementia Incidence in the Adult Changes in Thought Study. Environ Health Perspect. 2021 Aug; 129(8):87001. PMID: 34347531; PMCID: PMC8336685.
      Citations:    
    4. Liu C, Zeinomar N, Chung WK, Kiryluk K, Gharavi AG, Hripcsak G, Crew KD, Shang N, Khan A, Fasel D, Manolio TA, Jarvik GP, Rowley R, Justice AE, Rahm AK, Fullerton SM, Smoller JW, Larson EB, Crane PK, Dikilitas O, Wiesner GL, Bick AG, Terry MB, Weng C. Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry. JAMA Netw Open. 2021 Aug 02; 4(8):e2119084. PMID: 34347061; PMCID: PMC8339934.
      Citations:    
    5. Satterfield BA, Dikilitas O, Safarova MS, Clarke SL, Tcheandjieu C, Zhu X, Bastarache L, Larson EB, Justice AE, Shang N, Rosenthal EA, Shah AS, Namjou-Khales B, Urbina EM, Wei WQ, Feng Q, Jarvik GP, Hebbring SJ, de Andrade M, Manolio TA, Assimes TL, Kullo IJ. Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry. Circ Genom Precis Med. 2021 Aug; 14(4):e003354. PMID: 34282949.
      Citations:    
    6. Tabio L, Walker R, Crane PK, Gibbons LE, Kumar R, Power MC, Kelley AS, Larson EB, Dams-O'Connor K. Association of Lifetime TBI and Military Employment with Late-Life ADL Functioning: A Population-Based Prospective Cohort Study. Arch Phys Med Rehabil. 2021 Jul 17. PMID: 34283993.
      Citations:    
    7. Tuzzio L, Meyers CM, Dember LM, Grudzen CR, Melnick ER, Staman KL, Huang SS, Richards J, DeBar L, Vazquez MA, Green BB, Coronado GD, Jarvik JG, Braciszewski J, Ho PM, Wells BL, James K, Toto R, D'Onofrio G, Volandes A, Kuklinski MR, Catalano RF, Sterling SA, Morse EF, Curtis L, Larson EB. Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies. Healthc (Amst). 2021 Jun; 8 Suppl 1:100432. PMID: 34175091.
      Citations:    
    8. Lee CS, Latimer CS, Henriksen JC, Blazes M, Larson EB, Crane PK, Keene CD, Lee AY. Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathol. 2021 May 19; e12974. PMID: 34009663.
      Citations:    
    9. Larson EB, Stroud C. Meeting the Challenge of Caring for Persons Living With Dementia and Their Care Partners and Caregivers: A Report From the National Academies of Sciences, Engineering, and Medicine. JAMA. 2021 05 11; 325(18):1831-1832. PMID: 33835148.
      Citations:    
    10. Fan X, Wynn J, Shang N, Liu C, Fedotov A, Hallquist MLG, Buchanan AH, Williams MS, Smith ME, Hoell C, Rasmussen-Torvik LJ, Peterson JF, Wiesner GL, Murad AM, Jarvik GP, Gordon AS, Rosenthal EA, Stanaway IB, Crosslin DR, Larson EB, Leppig KA, Henrikson NB, Williams JL, Li R, Hebbring S, Weng C, Shen Y, Crew KD, Chung WK. Penetrance of Breast Cancer Susceptibility Genes From the eMERGE III Network. JNCI Cancer Spectr. 2021 Aug; 5(4):pkab044. PMID: 34377931; PMCID: PMC8346699.
      Citations:    
    11. Khan SS, Hoell C, Castillo LM, Connolly JJ, Crosslin DR, Chung WK, Gordon AS, Harr M, Jarvik GP, Kullo I, Larson EB, Leppig KA, Manolio T, Pacheco JA, Ralston JD, Puckelwartz MJ, Smith ME, Wells Q, McNally EM, Rasmussen-Torvik LJ. Practice Patterns After Return of Rare Variants Associated With Cardiomyopathy in the Electronic Medical Records and Genomics Network. Circ Heart Fail. 2021 May; 14(5):e008155. PMID: 33951936.
      Citations:    
    12. Zaslavsky O, Yu O, Walker RL, Crane PK, Gray SL, Sadak T, Borson S, Larson EB. Incident Dementia, Glycated Hemoglobin (HbA1c) Levels and Potentially Preventable Hospitalizations in People Age 65 and Older with Diabetes. J Gerontol A Biol Sci Med Sci. 2021 Apr 29. PMID: 33914085.
      Citations:    
    13. Burke BT, Latimer C, Keene CD, Sonnen JA, McCormick W, Bowen JD, McCurry SM, Larson EB, Crane PK. Theoretical impact of the AT(N) framework on dementia using a community autopsy sample. Alzheimers Dement. 2021 Apr 26. PMID: 33900044.
      Citations:    
    14. Shang N, Khan A, Polubriaginof F, Zanoni F, Mehl K, Fasel D, Drawz PE, Carrol RJ, Denny JC, Hathcock MA, Arruda-Olson AM, Peissig PL, Dart RA, Brilliant MH, Larson EB, Carrell DS, Pendergrass S, Verma SS, Ritchie MD, Benoit B, Gainer VS, Karlson EW, Gordon AS, Jarvik GP, Stanaway IB, Crosslin DR, Mohan S, Ionita-Laza I, Tatonetti NP, Gharavi AG, Hripcsak G, Weng C, Kiryluk K. Medical records-based chronic kidney disease phenotype for clinical care and "big data" observational and genetic studies. NPJ Digit Med. 2021 Apr 13; 4(1):70. PMID: 33850243; PMCID: PMC8044136.
      Citations:    
    15. Park S, Jung J, Larson EB. Preventable Health Behaviors, COVID-19 Severity Perceptions, and Vaccine Uptake in Traditional Medicare and Medicare Advantage: a Survey-Based Study. J Gen Intern Med. 2021 06; 36(6):1837-1840. PMID: 33846942; PMCID: PMC8041018.
      Citations:    
    16. Larson EB. In older adults, adding fall-risk screening with targeted interventions to mailed advice did not reduce fractures. Ann Intern Med. 2021 04; 174(4):JC46. PMID: 33819064.
      Citations:    
    17. Walker RL, Greenwood-Hickman MA, Bellettiere J, LaCroix AZ, Wing D, Higgins M, Richmire K, Larson EB, Crane PK, Rosenberg DE. Associations between physical function and device-based measures of physical activity and sedentary behavior patterns in older adults: moving beyond moderate-to-vigorous intensity physical activity. BMC Geriatr. 2021 03 31; 21(1):216. PMID: 33789584; PMCID: PMC8011072.
      Citations:    
    18. Postupna N, Rose SE, Gibbons LE, Coleman NM, Hellstern LL, Ritchie K, Wilson AM, Cudaback E, Li X, Melief EJ, Beller AE, Miller JA, Nolan AL, Marshall DA, Walker R, Montine TJ, Larson EB, Crane PK, Ellenbogen RG, Lein ES, Dams-O'Connor K, Keene CD. The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample. Front Neurol. 2021; 12:624696. PMID: 33796061; PMCID: PMC8008107.
      Citations:    
    19. Makhnoon S, Bowen DJ, Shirts BH, Fullerton SM, Meischke HW, Larson EB, Ralston JD, Leppig K, Crosslin DR, Veenstra D, Jarvik GP. Relationship between genetic knowledge and familial communication of CRC risk and intent to communicate CRCP genetic information: insights from FamilyTalk eMERGE III. Transl Behav Med. 2021 03 16; 11(2):563-572. PMID: 32579152; PMCID: PMC7963296.
      Citations:    
    20. Henrikson NB, Scrol A, Leppig KA, Ralston JD, Larson EB, Jarvik GP. Preferences of biobank participants for receiving actionable genomic test results: results of a recontacting study. Genet Med. 2021 06; 23(6):1163-1166. PMID: 33603197; PMCID: PMC8194390.
      Citations:    
    21. Makhnoon S, Bowen DJ, Shirts BH, Fullerton SM, Larson EB, Ralston JD, Leppig KA, Crosslin DR, Veenstra D, Jarvik GP. The FamilyTalk randomized controlled trial: patient-reported outcomes in clinical genetic sequencing for colorectal cancer. Cancer Causes Control. 2021 May; 32(5):483-492. PMID: 33591484.
      Citations:    
    22. den Brok MGHE, van Dalen JW, Abdulrahman H, Larson EB, van Middelaar T, van Gool WA, van Charante EPM, Richard E. Antihypertensive Medication Classes and the Risk of Dementia: A Systematic Review and Network Meta-Analysis. J Am Med Dir Assoc. 2021 07; 22(7):1386-1395.e15. PMID: 33460618.
      Citations:    
    23. Rosenthal EA, Crosslin DR, Gordon AS, Carrell DS, Stanaway IB, Larson EB, Grafton J, Wei WQ, Denny JC, Feng QP, Shah AS, Sturm AC, Ritchie MD, Pacheco JA, Hakonarson H, Rasmussen-Torvik LJ, Connolly JJ, Fan X, Safarova M, Kullo IJ, Jarvik GP. Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort. BMC Med Genomics. 2021 01 06; 14(1):11. PMID: 33407432; PMCID: PMC7789246.
      Citations:    
    24. Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113. PMID: 33074286; PMCID: PMC7573798.
      Citations:    
    25. Zhou J, Walker RL, Gray SL, Marcum ZA, Barthold D, Bowen JD, McCormick W, McCurry SM, Larson EB, Crane PK. Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups. J Alzheimers Dis. 2021; 80(1):79-90. PMID: 33554906.
      Citations:    
    26. Lee CS, Lee ML, Gibbons LE, Yanagihara RT, Blazes M, Kam JP, McCurry SM, Bowen JD, McCormick WC, Lee AY, Larson EB, Crane PK. Associations Between Retinal Artery/Vein Occlusions and Risk of Vascular Dementia. J Alzheimers Dis. 2021; 81(1):245-253. PMID: 33749651; PMCID: PMC8168611.
      Citations:    
    27. Shaffer RM, Li G, Adar SD, Dirk Keene C, Latimer CS, Crane PK, Larson EB, Kaufman JD, Carone M, Sheppard L. Fine Particulate Matter and Markers of Alzheimer's Disease Neuropathology at Autopsy in a Community-Based Cohort. J Alzheimers Dis. 2021; 79(4):1761-1773. PMID: 33459717; PMCID: PMC8061707.
      Citations:    
    28. Kumar RG, Jayasinghe N, Walker RL, Gibbons LE, Power MC, Larson EB, Crane PK, Dams-O'Connor K. Association of remote traumatic brain injury and military employment with late-life trajectories of depressive symptom severity. J Affect Disord. 2021 02 15; 281:376-383. PMID: 33348181.
      Citations:    
    29. van Dalen JW, Marcum ZA, Gray SL, Barthold D, Moll van Charante EP, van Gool WA, Crane PK, Larson EB, Richard E. Association of Angiotensin II-Stimulating Antihypertensive Use and Dementia Risk: Post Hoc Analysis of the PreDIVA Trial. Neurology. 2021 01 05; 96(1):e67-e80. PMID: 33154085; PMCID: PMC7884979.
      Citations:    
    30. Park S, Larson EB, Fishman P, White L, Coe NB. Differences in Health Care Utilization, Process of Diabetes Care, Care Satisfaction, and Health Status in Patients With Diabetes in Medicare Advantage Versus Traditional Medicare. Med Care. 2020 11; 58(11):1004-1012. PMID: 32925471; PMCID: PMC7572707.
      Citations:    
    31. Palmer MR, Kim DS, Crosslin DR, Stanaway IB, Rosenthal EA, Carrell DS, Cronkite DJ, Gordon A, Du X, Li YK, Williams MS, Weng C, Feng Q, Li R, Pendergrass SA, Hakonarson H, Fasel D, Sohn S, Sleiman P, Handelman SK, Speliotes E, Kullo IJ, Larson EB, eMERGE Consortium, Jarvik GP. Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network. Genet Epidemiol. 2021 02; 45(1):4-15. PMID: 32964493; PMCID: PMC7891640.
      Citations:    
    32. Fishman PA, White L, Ingraham B, Park S, Larson EB, Crane P, Coe NB. Health Care Costs of Alzheimer's and Related Dementias Within a Medicare Managed Care Provider. Med Care. 2020 09; 58(9):833-841. PMID: 32826748.
      Citations:    
    33. White L, Fishman P, Basu A, Crane PK, Larson EB, Coe NB. Dementia Is Associated With Earlier Mortality for Men and Women in the United States. Gerontol Geriatr Med. 2020 Jan-Dec; 6:2333721420945922. PMID: 32913883; PMCID: PMC7444147.
      Citations:    
    34. Grossman DC, Larson EB, Sox HC. Integrating Personalized Medicine With Population Health Management: The Path Forward. JAMA. 2020 Aug 18; 324(7):631-632. PMID: 32761169.
      Citations:    
    35. Rosenberg D, Walker R, Greenwood-Hickman MA, Bellettiere J, Xiang Y, Richmire K, Higgins M, Wing D, Larson EB, Crane PK, LaCroix AZ. Device-assessed physical activity and sedentary behavior in a community-based cohort of older adults. BMC Public Health. 2020 Aug 18; 20(1):1256. PMID: 32811454; PMCID: PMC7436994.
      Citations:    
    36. Zaslavsky O, Walker RL, Crane PK, Gray SL, Larson EB. Glucose control and cognitive and physical function in adults 80+ years of age with diabetes. Alzheimers Dement (N Y). 2020; 6(1):e12058. PMID: 32802933; PMCID: PMC7424264.
      Citations:    
    37. Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020 08 01; 143(8):2561-2575. PMID: 32844198; PMCID: PMC7447518.
      Citations:    
    38. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 08 08; 396(10248):413-446. PMID: 32738937; PMCID: PMC7392084.
      Citations:    
    39. Marcum ZA, Rosenberg D, Barnes DE, Yaffe K, Larson EB. Engaging Patients to Design the Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT) Intervention: Findings from a Web-Based Survey. J Alzheimers Dis Rep. 2020 Jul 23; 4(1):255-260. PMID: 32904663; PMCID: PMC7458551.
      Citations:    
    40. Tom SE, Phadke M, Hubbard RA, Crane PK, Stern Y, Larson EB. Association of Demographic and Early-Life Socioeconomic Factors by Birth Cohort With Dementia Incidence Among US Adults Born Between 1893 and 1949. JAMA Netw Open. 2020 07 01; 3(7):e2011094. PMID: 32716513.
      Citations:    
    41. Tuzzio L, Hanson LR, Reuben DB, Baier RR, Gurwitz JH, Bayliss EA, Williamson J, Fraser JR, Sherman SJ, Larson EB. Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems. J Am Geriatr Soc. 2020 07; 68 Suppl 2:S43-S48. PMID: 32589283; PMCID: PMC7419336.
      Citations:    
    42. Marcum ZA, Keene CD, Larson EB. Leveraging neuropathological data in pharmacoepidemiology: A promising approach for dementia prevention? Pharmacoepidemiol Drug Saf. 2021 01; 30(1):1-3. PMID: 32602137; PMCID: PMC7818889.
      Citations:    
    43. Lynch JA, Sharp RR, Aufox SA, Bland ST, Blout C, Bowen DJ, Buchanan AH, Halverson C, Harr M, Hebbring SJ, Henrikson N, Hoell C, Holm IA, Jarvik G, Kullo IJ, Kochan DC, Larson EB, Lazzeri A, Leppig KA, Madden J, Marasa M, Myers MF, Peterson J, Prows CA, Kulchak Rahm A, Ralston J, Milo Rasouly H, Scrol A, Smith ME, Sturm A, Stuttgen K, Wiesner G, Williams MS, Wynn J, Williams JL. Understanding the Return of Genomic Sequencing Results Process: Content Review of Participant Summary Letters in the eMERGE Research Network. J Pers Med. 2020 May 13; 10(2). PMID: 32413979; PMCID: PMC7354464.
      Citations:    
    44. Mosley JD, Levinson RT, Farber-Eger E, Edwards TL, Hellwege JN, Hung AM, Giri A, Shuey MM, Shaffer CM, Shi M, Brittain EL, Chung WK, Kullo IJ, Arruda-Olson AM, Jarvik GP, Larson EB, Crosslin DR, Williams MS, Borthwick KM, Hakonarson H, Denny JC, Wang TJ, Stein CM, Roden DM, Wells QS. The polygenic architecture of left ventricular mass mirrors the clinical epidemiology. Sci Rep. 2020 05 05; 10(1):7561. PMID: 32372017; PMCID: PMC7200691.
      Citations:    
    45. Wiesner GL, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Blout CL, Christensen KD, Chung WK, Clayton EW, Green RC, Harr MH, Henrikson N, Hoell C, Holm IA, Jarvik GP, Kullo IJ, Lammers PE, Larson EB, Lindor NM, Marasa M, F Myers M, Peterson JF, Prows CA, Ralston JD, Milo Rasouly H, Sharp RR, Smith ME, Van Driest SL, Williams JL, Williams MS, Wynn J, Leppig KA. Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network. J Pers Med. 2020 Apr 27; 10(2). PMID: 32349224; PMCID: PMC7354592.
      Citations:    
    46. Gray SL, Marcum ZA, Dublin S, Walker R, Golchin N, Rosenberg DE, Bowles EJ, Crane P, Larson EB. Association Between Medications Acting on the Central Nervous System and Fall-Related Injuries in Community-Dwelling Older Adults: A New User Cohort Study. J Gerontol A Biol Sci Med Sci. 2020 04 17; 75(5):1003-1009. PMID: 31755896; PMCID: PMC7164522.
      Citations:    
    47. Bustamante AC, Opron K, Ehlenbach WJ, Larson EB, Crane PK, Keene CD, Standiford TJ, Singer BH. Transcriptomic Profiles of Sepsis in the Human Brain. Am J Respir Crit Care Med. 2020 04 01; 201(7):861-863. PMID: 31940219; PMCID: PMC7124721.
      Citations:    
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    188. Ennis SK, Larson EB, Grothaus L, Helfrich CD, Balch S, Phelan EA. Association of living alone and hospitalization among community-dwelling elders with and without dementia. J Gen Intern Med. 2014 Nov; 29(11):1451-9. PMID: 24893584.
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    189. Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE, Schellenberg GD, Fardo DW. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 2014; 127(6):825-43. PMID: 24770881.
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    190. O'Hare AM, Hotchkiss JR, Kurella Tamura M, Larson EB, Hemmelgarn BR, Batten A, Do TP, Covinsky KE. Interpreting treatment effects from clinical trials in the context of real-world risk information: end-stage renal disease prevention in older adults. JAMA Intern Med. 2014 Mar; 174(3):391-7. PMID: 24424348.
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    191. Zollman FS, Starr C, Kondiles B, Cyborski C, Larson EB. The Rehabilitation Institute of Chicago Military Traumatic Brain Injury Screening Instrument: determination of sensitivity, specificity, and predictive value. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):99-107. PMID: 23756432.
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    192. Borenstein AR, Wu Y, Bowen JD, McCormick WC, Uomoto J, McCurry SM, Schellenberg GD, Larson EB. Incidence rates of dementia, Alzheimer disease, and vascular dementia in the Japanese American population in Seattle, WA: the Kame Project. Alzheimer Dis Assoc Disord. 2014 Jan-Mar; 28(1):23-9. PMID: 24045327.
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    193. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. PLoS One. 2013; 8(12):e81503. PMID: 24349080.
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    194. Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, Rasmussen LV, Crosslin DR, Crane PK, Pathak J, Bielinski SJ, Pendergrass SA, Xu H, Hindorff LA, Li R, Manolio TA, Chute CG, Chisholm RL, Larson EB, Jarvik GP, Brilliant MH, McCarty CA, Kullo IJ, Haines JL, Crawford DC, Masys DR, Roden DM. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol. 2013 Dec; 31(12):1102-10. PMID: 24270849.
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    195. Larson EB, Yaffe K, Langa KM. New insights into the dementia epidemic. N Engl J Med. 2013 Dec 12; 369(24):2275-7. PMID: 24283198.
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    197. Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec; 45(12):1452-8. PMID: 24162737.
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    198. Dublin S, Anderson ML, Heckbert SR, Hubbard RA, Sonnen JA, Crane PK, Montine TJ, Larson EB. Neuropathologic changes associated with atrial fibrillation in a population-based autopsy cohort. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):609-15. PMID: 24077599.
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    199. Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet. 2014 Jan; 133(1):95-109. PMID: 24026423.
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    200. Crane PK, Walker R, Hubbard RA, Li G, Nathan DM, Zheng H, Haneuse S, Craft S, Montine TJ, Kahn SE, McCormick W, McCurry SM, Bowen JD, Larson EB. Glucose levels and risk of dementia. N Engl J Med. 2013 Aug 08; 369(6):540-8. PMID: 23924004.
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    201. Nelson JC, Marsh T, Lumley T, Larson EB, Jackson LA, Jackson ML. Validation sampling can reduce bias in health care database studies: an illustration using influenza vaccination effectiveness. J Clin Epidemiol. 2013 Aug; 66(8 Suppl):S110-21. PMID: 23849144.
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    202. Larson EB. The body-mind connection in aging and dementia. J Am Geriatr Soc. 2013 Jul; 61(7):1210-1. PMID: 23855848; PMCID: PMC4157467.
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    203. Larson EB. Building trust in the power of "big data" research to serve the public good. JAMA. 2013 Jun 19; 309(23):2443-4. PMID: 23780455.
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    204. McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, Ritchie MD, Haines JL, Denny JC, Schellenberg GD, de Andrade M, Kullo I, Li R, Mirel D, Crenshaw A, Bowen JD, Li G, Tsuang D, McCurry S, Teri L, Larson EB, Jarvik GP, Carlson CS. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records. PLoS One. 2013; 8(6):e63481. PMID: 23762230.
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    205. Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA, Sanderson SC, Kannry J, Zinberg R, Basford MA, Brilliant M, Carey DJ, Chisholm RL, Chute CG, Connolly JJ, Crosslin D, Denny JC, Gallego CJ, Haines JL, Hakonarson H, Harley J, Jarvik GP, Kohane I, Kullo IJ, Larson EB, McCarty C, Ritchie MD, Roden DM, Smith ME, Böttinger EP, Williams MS. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med. 2013 Oct; 15(10):761-71. PMID: 23743551.
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    207. Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10; 309(14):1483-92. PMID: 23571587.
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    208. Schick UM, McDavid A, Crane PK, Weston N, Ehrlich K, Newton KM, Wallace R, Bookman E, Harrison T, Aragaki A, Crosslin DR, Wang SS, Reiner AP, Jackson RD, Peters U, Larson EB, Jarvik GP, Carlson CS. Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. PLoS One. 2013; 8(3):e59823. PMID: 23533652.
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    209. Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, Bradford Y, Rasmussen LV, Pathak J, Chute CG, Kullo IJ, McCarty CA, Chisholm RL, Kho AN, Carlson CS, Larson EB, Jarvik GP, Sotoodehnia N, Manolio TA, Li R, Masys DR, Haines JL, Roden DM. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 2013 Apr 02; 127(13):1377-85. PMID: 23463857.
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    210. Gray SL, Anderson ML, Hubbard RA, LaCroix A, Crane PK, McCormick W, Bowen JD, McCurry SM, Larson EB. Frailty and incident dementia. J Gerontol A Biol Sci Med Sci. 2013 Sep; 68(9):1083-90. PMID: 23419778.
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    211. Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. APOE e4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013 Feb; 70(2):223-8. PMID: 23407718.
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    212. Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson JG, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK, Larson EB, Carlson CS, Jarvik GP. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15; 22(10):2119-27. PMID: 23314186.
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    213. Cholerton B, Larson EB, Baker LD, Craft S, Crane PK, Millard SP, Sonnen JA, Montine TJ. Neuropathologic correlates of cognition in a population-based sample. J Alzheimers Dis. 2013; 36(4):699-709. PMID: 23666176.
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    214. O'Hare AM, Walker R, Haneuse S, Crane PK, McCormick WC, Bowen JD, Larson EB. Relationship between longitudinal measures of renal function and onset of dementia in a community cohort of older adults. J Am Geriatr Soc. 2012 Dec; 60(12):2215-22. PMID: 23231548.
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    215. Li G, Bekris LM, Leong L, Steinbart EJ, Shofer JB, Crane PK, Larson EB, Peskind ER, Bird TD, Yu CE. TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE e3/e3. Alzheimers Dement. 2013 Sep; 9(5):554-61. PMID: 23183136.
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    216. Dams-O'Connor K, Gibbons LE, Bowen JD, McCurry SM, Larson EB, Crane PK. Risk for late-life re-injury, dementia and death among individuals with traumatic brain injury: a population-based study. J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):177-82. PMID: 23172868.
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    217. Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Trojanowski JQ, Schellenberg GD, Yearout D, Huston H, Fritts-Penniman A, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology. 2012 Nov 06; 79(19):1944-50. PMID: 23035075.
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    218. Jun G, Vardarajan BN, Buros J, Yu CE, Hawk MV, Dombroski BA, Crane PK, Larson EB, Mayeux R, Haines JL, Lunetta KL, Pericak-Vance MA, Schellenberg GD, Farrer LA. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol. 2012 Oct; 69(10):1270-9. PMID: 22869155.
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    219. Larson EB, King J. "My mother was 67. . . ". Arch Intern Med. 2012 Aug 13; 172(15):1132. PMID: 22777486.
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    220. Greene SM, Reid RJ, Larson EB. Implementing the learning health system: from concept to action. Ann Intern Med. 2012 Aug 07; 157(3):207-10. PMID: 22868839.
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    221. Newton KM, Larson EB. Learning health care systems: leading through research: the 18th Annual HMO Research Network Conference, April 29-May 2, 2012, Seattle, Washington. Clin Med Res. 2012 Aug; 10(3):140-2. PMID: 22904375.
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    222. Reid RJ, Larson EB. Financial implications of the patient-centered medical home. JAMA. 2012 Jul 04; 308(1):83-4. PMID: 22729555.
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    223. Montine TJ, Sonnen JA, Montine KS, Crane PK, Larson EB. Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics. Curr Alzheimer Res. 2012 Jul; 9(6):718-23. PMID: 22471861.
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    224. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. PMID: 22722634.
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    225. Trinidad SB, Fullerton SM, Bares JM, Jarvik GP, Larson EB, Burke W. Informed Consent in Genome-Scale Research: What Do Prospective Participants Think? AJOB Prim Res. 2012 Jul 01; 3(3):3-11. PMID: 23493836.
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    226. Reid RJ, McBride CM, Alford SH, Price C, Baxevanis AD, Brody LC, Larson EB. Association between health-service use and multiplex genetic testing. Genet Med. 2012 Oct; 14(10):852-9. PMID: 22595941.
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    227. Larson EB, Langa KM. Aging and incidence of dementia: A critical question. Neurology. 2012 May 08; 78(19):1452-3. PMID: 22551724.
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    228. Hsu C, Coleman K, Ross TR, Johnson E, Fishman PA, Larson EB, Liss D, Trescott C, Reid RJ. Spreading a patient-centered medical home redesign: a case study. J Ambul Care Manage. 2012 Apr-Jun; 35(2):99-108. PMID: 22415283.
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    229. Fishman PA, Johnson EA, Coleman K, Larson EB, Hsu C, Ross TR, Liss D, Tufano J, Reid RJ. Impact on seniors of the patient-centered medical home: evidence from a pilot study. Gerontologist. 2012 Oct; 52(5):703-11. PMID: 22421916.
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    230. O'Hare AM, Batten A, Burrows NR, Pavkov ME, Taylor L, Gupta I, Todd-Stenberg J, Maynard C, Rodriguez RA, Murtagh FE, Larson EB, Williams DE. Trajectories of kidney function decline in the 2 years before initiation of long-term dialysis. Am J Kidney Dis. 2012 Apr; 59(4):513-22. PMID: 22305760.
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    231. Phelan EA, Borson S, Grothaus L, Balch S, Larson EB. Association of incident dementia with hospitalizations. JAMA. 2012 Jan 11; 307(2):165-72. PMID: 22235087.
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    232. Ridpath JR, Larson EB, Greene SM. Can integrating health literacy into the patient-centered medical home help us weather the perfect storm? J Gen Intern Med. 2012 May; 27(5):588-94. PMID: 22215273.
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    233. Cholerton B, Baker LD, Trittschuh EH, Crane PK, Larson EB, Arbuckle M, Saucedo HH, McCurry SM, Bowen JD, McCormick WC, Craft S. Insulin and sex interactions in older adults with mild cognitive impairment. J Alzheimers Dis. 2012; 31(2):401-10. PMID: 22571978.
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    234. Postupna N, Rose SE, Bird TD, Gonzalez-Cuyar LF, Sonnen JA, Larson EB, Keene CD, Montine TJ. Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults. Brain Pathol. 2012 Jul; 22(4):472-84. PMID: 21999410.
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    235. Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Pretel S, Saip A, Ritchie MD, Crawford DC, Crane PK, Newton K, Li R, Mirel DB, Crenshaw A, Larson EB, Carlson CS, Jarvik GP. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet. 2012 Apr; 131(4):639-52. PMID: 22037903.
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    236. Boudreau DM, Yu O, Gray SL, Raebel MA, Johnson J, Larson EB. Concomitant use of cholinesterase inhibitors and anticholinergics: prevalence and outcomes. J Am Geriatr Soc. 2011 Nov; 59(11):2069-76. PMID: 22091958.
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    237. O'Hare AM, Choi AI, Boscardin WJ, Clinton WL, Zawadzki I, Hebert PL, Kurella Tamura M, Taylor L, Larson EB. Trends in timing of initiation of chronic dialysis in the United States. Arch Intern Med. 2011 Oct 10; 171(18):1663-9. PMID: 21987197.
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    238. Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet. 2011 Oct 07; 89(4):529-42. PMID: 21981779.
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    239. Fishman PA, Anderson ML, Cook AJ, Ralston JD, Catz SL, Carlson J, Larson EB, Green BB. Accuracy of blood pressure measurements reported in an electronic medical record during routine primary care visits. J Clin Hypertens (Greenwich). 2011 Nov; 13(11):821-8. PMID: 22051427.
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    240. Li G, Wang LY, Shofer JB, Thompson ML, Peskind ER, McCormick W, Bowen JD, Crane PK, Larson EB. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry. 2011 Sep; 68(9):970-7. PMID: 21893662.
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    241. Back SA, Kroenke CD, Sherman LS, Lawrence G, Gong X, Taber EN, Sonnen JA, Larson EB, Montine TJ. White matter lesions defined by diffusion tensor imaging in older adults. Ann Neurol. 2011 Sep; 70(3):465-76. PMID: 21905080.
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    242. Dublin S, Anderson ML, Haneuse SJ, Heckbert SR, Crane PK, Breitner JC, McCormick W, Bowen JD, Teri L, McCurry SM, Larson EB. Atrial fibrillation and risk of dementia: a prospective cohort study. J Am Geriatr Soc. 2011 Aug; 59(8):1369-75. PMID: 21806558.
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    243. Sonnen JA, Santa Cruz K, Hemmy LS, Woltjer R, Leverenz JB, Montine KS, Jack CR, Kaye J, Lim K, Larson EB, White L, Montine TJ. Ecology of the aging human brain. Arch Neurol. 2011 Aug; 68(8):1049-56. PMID: 21825242.
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    244. McCurry SM, Pike KC, Vitiello MV, Logsdon RG, Larson EB, Teri L. Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial. J Am Geriatr Soc. 2011 Aug; 59(8):1393-402. PMID: 21797835.
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    245. Larson EB. Brains and aging: Comment on "Physical activity and cognition in women with vascular conditions" and "Activity energy expenditure and incident cognitive impairment in older adults". Arch Intern Med. 2011 Jul 25; 171(14):1258-9. PMID: 21771895.
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    246. Teri L, McCurry SM, Logsdon RG, Gibbons LE, Buchner DM, Larson EB. A randomized controlled clinical trial of the Seattle Protocol for Activity in older adults. J Am Geriatr Soc. 2011 Jul; 59(7):1188-96. PMID: 21718259.
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    247. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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    248. Gates GA, Anderson ML, McCurry SM, Feeney MP, Larson EB. Central auditory dysfunction as a harbinger of Alzheimer dementia. Arch Otolaryngol Head Neck Surg. 2011 Apr; 137(4):390-5. PMID: 21502479.
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    249. White AA, Bell SK, Krauss MJ, Garbutt J, Dunagan WC, Fraser VJ, Levinson W, Larson EB, Gallagher TH. How trainees would disclose medical errors: educational implications for training programmes. Med Educ. 2011 Apr; 45(4):372-80. PMID: 21401685.
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    250. Snapinn KW, Larson EB, Kawakami H, Ujike H, Borenstein AR, Izumi Y, Kaji R, Maruyama H, Mata IF, Morino H, Oda M, Tsuang DW, Yearout D, Edwards KL, Zabetian CP. The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population. Parkinsonism Relat Disord. 2011 Jul; 17(6):473-5. PMID: 21345711.
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    251. Gray SL, Walker R, Dublin S, Haneuse S, Crane PK, Breitner JC, Bowen J, McCormick W, Larson EB. Histamine-2 receptor antagonist use and incident dementia in an older cohort. J Am Geriatr Soc. 2011 Feb; 59(2):251-7. PMID: 21314645.
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    252. McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics. 2011 Jan 26; 4:13. PMID: 21269473.
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    253. Trinidad SB, Fullerton SM, Ludman EJ, Jarvik GP, Larson EB, Burke W. Research ethics. Research practice and participant preferences: the growing gulf. Science. 2011 Jan 21; 331(6015):287-8. PMID: 21252333.
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    254. Knopman DS, Petersen RC, Rocca WA, Larson EB, Ganguli M. Passive case-finding for Alzheimer's disease and dementia in two U.S. communities. Alzheimers Dement. 2011 Jan; 7(1):53-60. PMID: 21255743.
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    255. Rocca WA, Petersen RC, Knopman DS, Hebert LE, Evans DA, Hall KS, Gao S, Unverzagt FW, Langa KM, Larson EB, White LR. Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States. Alzheimers Dement. 2011 Jan; 7(1):80-93. PMID: 21255746.
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    256. Trittschuh EH, Crane PK, Larson EB, Cholerton B, McCormick WC, McCurry SM, Bowen JD, Baker LD, Craft S. Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community based sample. J Alzheimers Dis. 2011; 25(1):163-73. PMID: 21368379.
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    257. Gates GA, Gibbons LE, McCurry SM, McCusrry SM, Crane PK, Feeney MP, Larson EB. Executive dysfunction and presbycusis in older persons with and without memory loss and dementia. Cogn Behav Neurol. 2010 Dec; 23(4):218-23. PMID: 21150347.
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    258. Larson EB. N-of-1 trials: a new future? J Gen Intern Med. 2010 Sep; 25(9):891-2. PMID: 20632123.
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    259. Sonnen JA, Larson EB, Walker RL, Haneuse S, Crane PK, Gray SL, Breitner JC, Montine TJ. Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques. Neurology. 2010 Sep 28; 75(13):1203-10. PMID: 20811000.
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    260. Ludman EJ, Fullerton SM, Spangler L, Trinidad SB, Fujii MM, Jarvik GP, Larson EB, Burke W. Glad you asked: participants' opinions of re-consent for dbGap data submission. J Empir Res Hum Res Ethics. 2010 Sep; 5(3):9-16. PMID: 20831417.
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    261. Weppner WG, Ralston JD, Koepsell TD, Grothaus LC, Reid RJ, Jordan L, Larson EB. Use of a shared medical record with secure messaging by older patients with diabetes. Diabetes Care. 2010 Nov; 33(11):2314-9. PMID: 20739686.
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    262. Trinidad SB, Fullerton SM, Bares JM, Jarvik GP, Larson EB, Burke W. Genomic research and wide data sharing: views of prospective participants. Genet Med. 2010 Aug; 12(8):486-95. PMID: 20535021.
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    263. McCurry SM, Pike KC, Logsdon RG, Vitiello MV, Larson EB, Teri L. Predictors of short- and long-term adherence to a daily walking program in persons with Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2010 Sep; 25(6):505-12. PMID: 20660515.
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    264. O'Hare AM, Rodriguez RA, Hailpern SM, Larson EB, Kurella Tamura M. Regional variation in health care intensity and treatment practices for end-stage renal disease in older adults. JAMA. 2010 Jul 14; 304(2):180-6. PMID: 20628131.
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    265. Larson EB. Prospects for delaying the rising tide of worldwide, late-life dementias. Int Psychogeriatr. 2010 Dec; 22(8):1196-202. PMID: 20594386.
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    266. Li G, Shofer JB, Rhew IC, Kukull WA, Peskind ER, McCormick W, Bowen JD, Schellenberg GD, Crane PK, Breitner JC, Larson EB. Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc. 2010 Jul; 58(7):1311-7. PMID: 20533968.
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    267. Reid RJ, Coleman K, Johnson EA, Fishman PA, Hsu C, Soman MP, Trescott CE, Erikson M, Larson EB. The Group Health medical home at year two: cost savings, higher patient satisfaction, and less burnout for providers. Health Aff (Millwood). 2010 May; 29(5):835-43. PMID: 20439869.
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    268. Sonnen JA, Postupna N, Larson EB, Crane PK, Rose SE, Montine KS, Leverenz JB, Montine TJ. Pathologic correlates of dementia in individuals with Lewy body disease. Brain Pathol. 2010 May; 20(3):654-9. PMID: 20522091.
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    269. Larson EB, Reid R. The patient-centered medical home movement: why now? JAMA. 2010 Apr 28; 303(16):1644-5. PMID: 20424256.
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    270. Ralston JD, Coleman K, Reid RJ, Handley MR, Larson EB. Patient experience should be part of meaningful-use criteria. Health Aff (Millwood). 2010 Apr; 29(4):607-13. PMID: 20368589.
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    271. Hensley Alford S, McBride CM, Reid RJ, Larson EB, Baxevanis AD, Brody LC. Participation in genetic testing research varies by social group. Public Health Genomics. 2011; 14(2):85-93. PMID: 20299772.
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    272. Ehlenbach WJ, Hough CL, Crane PK, Haneuse SJ, Carson SS, Curtis JR, Larson EB. Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA. 2010 Feb 24; 303(8):763-70. PMID: 20179286.
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    273. Boger-Megiddo I, Heckbert SR, Weiss NS, McKnight B, Furberg CD, Wiggins KL, Delaney JA, Siscovick DS, Larson EB, Lemaitre RN, Smith NL, Rice KM, Glazer NL, Psaty BM. Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study. BMJ. 2010 Jan 25; 340:c103. PMID: 20100777.
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    274. Montine TJ, Larson EB. Late-life dementias: does this unyielding global challenge require a broader view? JAMA. 2009 Dec 16; 302(23):2593-4. PMID: 20009062.
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    275. Weppner WG, Hollon MF, Chew LD, Larson EB. Direct-to-consumer offers for free and discounted medications on the internet: a content analysis of "e-samples". Arch Intern Med. 2009 Nov 23; 169(21):2024-30. PMID: 19933966.
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    276. Larson EB. Group Health Cooperative--one coverage-and-delivery model for accountable care. N Engl J Med. 2009 Oct 22; 361(17):1620-2. PMID: 19846846.
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    277. Wang LY, Larson EB, Sonnen JA, Shofer JB, McCormick W, Bowen JD, Montine TJ, Li G. Blood pressure and brain injury in older adults: findings from a community-based autopsy study. J Am Geriatr Soc. 2009 Nov; 57(11):1975-81. PMID: 19793158.
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    278. Reid RJ, Fishman PA, Yu O, Ross TR, Tufano JT, Soman MP, Larson EB. Patient-centered medical home demonstration: a prospective, quasi-experimental, before and after evaluation. Am J Manag Care. 2009 Sep 01; 15(9):e71-87. PMID: 19728768.
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    279. McBride CM, Alford SH, Reid RJ, Larson EB, Baxevanis AD, Brody LC. Characteristics of users of online personalized genomic risk assessments: implications for physician-patient interactions. Genet Med. 2009 Aug; 11(8):582-7. PMID: 19606049.
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    280. Khachaturian ZS, Camí J, Andrieu S, Avila J, Boada Rovira M, Breteler M, Froelich L, Gauthier S, Gómez-Isla T, Khachaturian AS, Kuller LH, Larson EB, Lopez OL, Martinez-Lage JM, Petersen RC, Schellenberg GD, Sunyer J, Vellas B, Bain LJ. Creating a transatlantic research enterprise for preventing Alzheimer's disease. Alzheimers Dement. 2009 Jul; 5(4):361-6. PMID: 19560106.
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    281. Kilo CM, Larson EB. Exploring the harmful effects of health care. JAMA. 2009 Jul 01; 302(1):89-91. PMID: 19567446.
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    282. Longstreth WT, Sonnen JA, Koepsell TD, Kukull WA, Larson EB, Montine TJ. Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):291-4. PMID: 19812473.
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    283. Ralston JD, Martin DP, Anderson ML, Fishman PA, Conrad DA, Larson EB, Grembowski D. Group health cooperative's transformation toward patient-centered access. Med Care Res Rev. 2009 Dec; 66(6):703-24. PMID: 19549993.
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    284. Dublin S, Jackson ML, Nelson JC, Weiss NS, Larson EB, Jackson LA. Statin use and risk of community acquired pneumonia in older people: population based case-control study. BMJ. 2009 Jun 16; 338:b2137. PMID: 19531550.
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    285. Tsuang D, Larson EB, Li G, Shofer JB, Montine KS, Thompson ML, Sonnen JA, Crane PK, Leverenz JB, Montine TJ. Association between lifetime cigarette smoking and lewy body accumulation. Brain Pathol. 2010 Mar; 20(2):412-8. PMID: 19531100.
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    286. O'Hare AM, Kaufman JS, Covinsky KE, Landefeld CS, McFarland LV, Larson EB. Current guidelines for using angiotensin-converting enzyme inhibitors and angiotensin II-receptor antagonists in chronic kidney disease: is the evidence base relevant to older adults? Ann Intern Med. 2009 May 19; 150(10):717-24. PMID: 19451579.
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    287. Hughes TF, Borenstein AR, Schofield E, Wu Y, Larson EB. Association between late-life body mass index and dementia: The Kame Project. Neurology. 2009 May 19; 72(20):1741-6. PMID: 19451529.
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    288. Zabetian CP, Yamamoto M, Lopez AN, Ujike H, Mata IF, Izumi Y, Kaji R, Maruyama H, Morino H, Oda M, Hutter CM, Edwards KL, Schellenberg GD, Tsuang DW, Yearout D, Larson EB, Kawakami H. LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease. Mov Disord. 2009 May 15; 24(7):1034-41. PMID: 19343804; PMCID: PMC2827255.
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    289. Wang LY, Leverenz JB, Larson EB, Vavrek DA, Kukull WA, McCormick W, Bowen JD, Teri L, Montine T, Tsuang DW. Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample. J Geriatr Psychiatry Neurol. 2009 Dec; 22(4):256-65. PMID: 19433862.
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    290. Breitner JC, Haneuse SJ, Walker R, Dublin S, Crane PK, Gray SL, Larson EB. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology. 2009 Jun 02; 72(22):1899-905. PMID: 19386997.
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    291. Tsuang D, Larson EB, Bolen E, Thompson ML, Peskind E, Bowen J, McCormick W, Teri L, Kukull W, Vavrek D, Montine T, Leverenz JB. Visual hallucinations in dementia: a prospective community-based study with autopsy. Am J Geriatr Psychiatry. 2009 Apr; 17(4):317-23. PMID: 19307860.
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    292. Sonnen JA, Larson EB, Gray SL, Wilson A, Kohama SG, Crane PK, Breitner JC, Montine TJ. Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann Neurol. 2009 Feb; 65(2):226-9. PMID: 19259965.
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    293. Larson EB. Evidence, guidelines, performance incentives, complexity, and old people: a clinician's dilemma. J Am Geriatr Soc. 2009 Feb; 57(2):353-4. PMID: 19207151.
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    294. Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer R, Montine TJ, Craft S. Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol. 2009 Mar; 66(3):315-22. PMID: 19139294.
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    295. Hindorff LA, Burke W, Laberge AM, Rice KM, Lumley T, Leppig K, Rosendaal FR, Larson EB, Psaty BM. Motivating factors for physician ordering of factor V Leiden genetic tests. Arch Intern Med. 2009 Jan 12; 169(1):68-74. PMID: 19139326.
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    296. Larson EB. Population-based neuropathology: the best of times. J Alzheimers Dis. 2009; 18(3):643-4. PMID: 19625745.
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    297. Sonnen JA, Larson EB, Haneuse S, Woltjer R, Li G, Crane PK, Craft S, Montine TJ. Neuropathology in the adult changes in thought study: a review. J Alzheimers Dis. 2009; 18(3):703-11. PMID: 19661627.
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    298. Gibbons LE, McCurry S, Rhoads K, Masaki K, White L, Borenstein AR, Larson EB, Crane PK. Japanese-English language equivalence of the Cognitive Abilities Screening Instrument among Japanese-Americans. Int Psychogeriatr. 2009 Feb; 21(1):129-37. PMID: 18947456.
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    299. Grembowski D, Anderson ML, Conrad DA, Fishman PA, Larson EB, Martin DP, Ralston JD, Carrell D, Hecht J. Evaluation of the group health cooperative access initiative: study design challenges in estimating the impact of a large-scale organizational transformation. Qual Manag Health Care. 2008 Oct-Dec; 17(4):292-303. PMID: 19020399.
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    300. Williams RL, Johnson SB, Greene SM, Larson EB, Green LA, Morris A, Confer D, Reaman G, Madigan R, Kahn J. Signposts along the NIH roadmap for reengineering clinical research: lessons from the Clinical Research Networks initiative. Arch Intern Med. 2008 Sep 22; 168(17):1919-25. PMID: 18809820.
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    301. Larson EB. Physical activity for older adults at risk for Alzheimer disease. JAMA. 2008 Sep 03; 300(9):1077-9. PMID: 18768421.
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    302. McBride CM, Alford SH, Reid RJ, Larson EB, Baxevanis AD, Brody LC. Putting science over supposition in the arena of personalized genomics. Nat Genet. 2008 Aug; 40(8):939-42. PMID: 18665132.
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    303. Siegel GJ, Chauhan NB, Feinstein DL, Li G, Larson EB, Breitner JC, Montine TJ. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology. 2008 Jul 29; 71(5):383; author reply 383. PMID: 18663190.
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    304. Larson EB, Langa KM. The rising tide of dementia worldwide. Lancet. 2008 Aug 09; 372(9637):430-2. PMID: 18667232.
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    305. Woltjer RL, Sonnen JA, Sokal I, Rung LG, Yang W, Kjerulf JD, Klingert D, Johnson C, Rhew I, Tsuang D, Crane PK, Larson EB, Montine TJ. Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly. Brain Pathol. 2009 Jul; 19(3):365-74. PMID: 18652590.
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    306. Gates GA, Anderson ML, Feeney MP, McCurry SM, Larson EB. Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia. Arch Otolaryngol Head Neck Surg. 2008 Jul; 134(7):771-7. PMID: 18645130.
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    307. Green BB, Cook AJ, Ralston JD, Fishman PA, Catz SL, Carlson J, Carrell D, Tyll L, Larson EB, Thompson RS. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA. 2008 Jun 25; 299(24):2857-67. PMID: 18577730.
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    308. Crane PK, Narasimhalu K, Gibbons LE, Mungas DM, Haneuse S, Larson EB, Kuller L, Hall K, van Belle G. Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline. J Clin Epidemiol. 2008 Oct; 61(10):1018-27.e9. PMID: 18455909.
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    309. Langa KM, Larson EB, Karlawish JH, Cutler DM, Kabeto MU, Kim SY, Rosen AB. Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity? Alzheimers Dement. 2008 Mar; 4(2):134-44. PMID: 18631957.
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    310. White AA, Gallagher TH, Krauss MJ, Garbutt J, Waterman AD, Dunagan WC, Fraser VJ, Levinson W, Larson EB. The attitudes and experiences of trainees regarding disclosing medical errors to patients. Acad Med. 2008 Mar; 83(3):250-6. PMID: 18316869.
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    311. Lovasi GS, Moudon AV, Pearson AL, Hurvitz PM, Larson EB, Siscovick DS, Berke EM, Lumley T, Psaty BM. Using built environment characteristics to predict walking for exercise. Int J Health Geogr. 2008 Feb 29; 7:10. PMID: 18312660.
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    312. Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol. 2008 Apr; 18(2):220-4. PMID: 18241240.
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    313. Larson EB. Physicians should be civic professionals, not just knowledge workers. Am J Med. 2007 Nov; 120(11):1005-9. PMID: 17976431.
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    314. Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ. Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol. 2007 Oct; 62(4):406-13. PMID: 17879383.
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    315. Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology. 2007 Aug 28; 69(9):878-85. PMID: 17724290.
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    316. Li G, Rhew IC, Shofer JB, Kukull WA, Breitner JC, Peskind E, Bowen JD, McCormick W, Teri L, Crane PK, Larson EB. Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study. J Am Geriatr Soc. 2007 Aug; 55(8):1161-7. PMID: 17661953.
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    317. Morden NE, Zerzan JT, Larson EB. Alzheimer's disease medication: use and cost projections for Medicare Part D. J Am Geriatr Soc. 2007 Apr; 55(4):622-4. PMID: 17397444.
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    318. Berke EM, Gottlieb LM, Moudon AV, Larson EB. Protective association between neighborhood walkability and depression in older men. J Am Geriatr Soc. 2007 Apr; 55(4):526-33. PMID: 17397430.
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    319. Berke EM, Koepsell TD, Moudon AV, Hoskins RE, Larson EB. Association of the built environment with physical activity and obesity in older persons. Am J Public Health. 2007 Mar; 97(3):486-92. PMID: 17267713.
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    320. Tsuang D, Simpson K, Larson EB, Peskind E, Kukull W, Bowen JB, McCormick W, Teri L, Montine T, Thompson ML, Leverenz JB. Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease. J Geriatr Psychiatry Neurol. 2006 Dec; 19(4):195-201. PMID: 17085757.
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    321. Kurland BF, Gill TM, Patrick DL, Larson EB, Phelan EA. Longitudinal change in positive affect in community-dwelling older persons. J Am Geriatr Soc. 2006 Dec; 54(12):1846-53. PMID: 17198489.
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    322. Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med. 2006 Sep; 119(9):751-9. PMID: 16945610.
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    323. Ramos EM, Lin MT, Larson EB, Maezawa I, Tseng LH, Edwards KL, Schellenberg GD, Hansen JA, Kukull WA, Jin LW. Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol. 2006 Aug; 63(8):1165-9. PMID: 16908746.
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    324. Gallagher TH, Garbutt JM, Waterman AD, Flum DR, Larson EB, Waterman BM, Dunagan WC, Fraser VJ, Levinson W. Choosing your words carefully: how physicians would disclose harmful medical errors to patients. Arch Intern Med. 2006 Aug 14-28; 166(15):1585-93. PMID: 16908791.
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    325. Wang L, Larson EB, Bowen JD, van Belle G. Performance-based physical function and future dementia in older people. Arch Intern Med. 2006 May 22; 166(10):1115-20. PMID: 16717174.
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    326. Lemaitre RN, Weiss NS, Smith NL, Psaty BM, Lumley T, Larson EB, Heckbert SR. Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke. Arch Intern Med. 2006 Feb 27; 166(4):399-404. PMID: 16505258.
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    327. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006 Jan 17; 144(2):73-81. PMID: 16418406.
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    328. Jackson LA, Nelson JC, Benson P, Neuzil KM, Reid RJ, Psaty BM, Heckbert SR, Larson EB, Weiss NS. Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol. 2006 Apr; 35(2):345-52. PMID: 16368724.
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    329. Li G, Shofer JB, Kukull WA, Peskind ER, Tsuang DW, Breitner JC, McCormick W, Bowen JD, Teri L, Schellenberg GD, Larson EB. Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. Neurology. 2005 Oct 11; 65(7):1045-50. PMID: 16217057.
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    330. Bowen JD, Kamin R, Leverenz JB, Fishel MA, McCormick WC, Kukull WA, Larson EB. Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementia. J Am Geriatr Soc. 2005 Oct; 53(10):1743-7. PMID: 16181174.
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    331. Bond GE, Burr RL, McCurry SM, Rice MM, Borenstein AR, Larson EB. Alcohol and cognitive performance: a longitudinal study of older Japanese Americans. The Kame Project. Int Psychogeriatr. 2005 Dec; 17(4):653-68. PMID: 16185373.
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    332. Woltjer RL, Cimino PJ, Boutté AM, Schantz AM, Montine KS, Larson EB, Bird T, Quinn JF, Zhang J, Montine TJ. Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease. FASEB J. 2005 Nov; 19(13):1923-5. PMID: 16129700.
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    333. Sheffield JV, Larson EB. Update in general internal medicine. Ann Intern Med. 2005 Aug 02; 143(3):212-21. PMID: 16061919.
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    334. Kraybill ML, Larson EB, Tsuang DW, Teri L, McCormick WC, Bowen JD, Kukull WA, Leverenz JB, Cherrier MM. Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology. 2005 Jun 28; 64(12):2069-73. PMID: 15985574.
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    335. Larson EB, Roberts KB, Grumbach K. Primary care, generalism, public good: déjà vu? Again! Ann Intern Med. 2005 Apr 19; 142(8):671-4. PMID: 15838076.
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    336. Larson EB, Grumbach K, Roberts KB. The future of generalism in medicine. Ann Intern Med. 2005 Apr 19; 142(8):689-90. PMID: 15838087.
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    337. Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB. Evaluation of selection bias in an incident-based dementia autopsy case series. Alzheimer Dis Assoc Disord. 2005 Apr-Jun; 19(2):67-73. PMID: 15942323.
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    338. Larson EB, Yao X. Clinical empathy as emotional labor in the patient-physician relationship. JAMA. 2005 Mar 02; 293(9):1100-6. PMID: 15741532.
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    339. Borenstein AR, Wu Y, Mortimer JA, Schellenberg GD, McCormick WC, Bowen JD, McCurry S, Larson EB. Developmental and vascular risk factors for Alzheimer's disease. Neurobiol Aging. 2005 Mar; 26(3):325-34. PMID: 15639310.
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    340. Fillenbaum GG, McCurry SM, Kuchibhatla M, Masaki KH, Borenstein AR, Foley DJ, Heyman A, Larson EB, White L. Performance on the CERAD neuropsychology battery of two samples of Japanese-American elders: norms for persons with and without dementia. J Int Neuropsychol Soc. 2005 Mar; 11(2):192-201. PMID: 15966108.
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    341. Shadlen MF, Larson EB, Wang L, Phelan EA, McCormick WC, Jolley L, Teri L, van Belle G. Education modifies the effect of apolipoprotein epsilon 4 on cognitive decline. Neurobiol Aging. 2005 Jan; 26(1):17-24. PMID: 15585342.
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    342. Ralston JD, Larson EB. Crossing to safety: transforming healthcare organizations for patient safety. J Postgrad Med. 2005 Jan-Mar; 51(1):61-7. PMID: 15793345.
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    343. Greene SM, Larson EB, Boudreau DM, Johnson KE, Ralston J, Reid R, Fishman P. The coordinated clinical studies network: a multidisciplinary alliance to facilitate research and improve care. Perm J. 2005; 9(4):33-5. PMID: 22811643.
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    344. Langa KM, Foster NL, Larson EB. Mixed dementia: emerging concepts and therapeutic implications. JAMA. 2004 Dec 15; 292(23):2901-8. PMID: 15598922.
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    345. Wang L, van Belle G, Crane PK, Kukull WA, Bowen JD, McCormick WC, Larson EB. Subjective memory deterioration and future dementia in people aged 65 and older. J Am Geriatr Soc. 2004 Dec; 52(12):2045-51. PMID: 15571540.
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    346. Li G, Higdon R, Kukull WA, Peskind E, Van Valen Moore K, Tsuang D, van Belle G, McCormick W, Bowen JD, Teri L, Schellenberg GD, Larson EB. Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study. Neurology. 2004 Nov 09; 63(9):1624-8. PMID: 15534246.
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    347. Bond GE, Burr R, McCurry SM, Rice MM, Borenstein AR, Kukull WA, Teri L, Bowen JD, McCormick WC, Larson EB. Alcohol, gender, and cognitive performance: a longitudinal study comparing older Japanese and non-Hispanic white Americans. J Aging Health. 2004 Nov; 16(5):615-40. PMID: 15448275.
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    348. Tencer AF, Koepsell TD, Wolf ME, Frankenfeld CL, Buchner DM, Kukull WA, LaCroix AZ, Larson EB, Tautvydas M. Biomechanical properties of shoes and risk of falls in older adults. J Am Geriatr Soc. 2004 Nov; 52(11):1840-6. PMID: 15507060.
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    349. Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D. Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study. J Am Geriatr Soc. 2004 Sep; 52(9):1442-8. PMID: 15341544.
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    350. Koepsell TD, Wolf ME, Buchner DM, Kukull WA, LaCroix AZ, Tencer AF, Frankenfeld CL, Tautvydas M, Larson EB. Footwear style and risk of falls in older adults. J Am Geriatr Soc. 2004 Sep; 52(9):1495-501. PMID: 15341551.
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    351. Showstack J, Lurie N, Larson EB, Rothman AA, Hassmiller SB. The future of primary care. AHIP Cover. 2004 May-Jun; 45(3):55-6, 58, 60. PMID: 15318426.
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    352. Larson EB. Health care system chaos should spur innovation: summary of a report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine. Ann Intern Med. 2004 Apr 20; 140(8):639-43. PMID: 15096335.
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    353. Larson EB, Shadlen MF, Wang L, McCormick WC, Bowen JD, Teri L, Kukull WA. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med. 2004 Apr 06; 140(7):501-9. PMID: 15068977.
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    354. Larson EB, Wang L. Exercise, aging, and Alzheimer disease. Alzheimer Dis Assoc Disord. 2004 Apr-Jun; 18(2):54-6. PMID: 15249847.
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    355. Langa KM, Larson EB, Wallace RB, Fendrick AM, Foster NL, Kabeto MU, Weir DR, Willis RJ, Herzog AR. Out-of-pocket health care expenditures among older Americans with dementia. Alzheimer Dis Assoc Disord. 2004 Apr-Jun; 18(2):90-8. PMID: 15249853.
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    356. Gendo K, Larson EB. Evidence-based diagnostic strategies for evaluating suspected allergic rhinitis. Ann Intern Med. 2004 Feb 17; 140(4):278-89. PMID: 14970151.
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    357. Phelan EA, Anderson LA, LaCroix AZ, Larson EB. Older adults' views of "successful aging"--how do they compare with researchers' definitions? J Am Geriatr Soc. 2004 Feb; 52(2):211-6. PMID: 14728629.
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    358. Crane PK, van Belle G, Larson EB. Test bias in a cognitive test: differential item functioning in the CASI. Stat Med. 2004 Jan 30; 23(2):241-56. PMID: 14716726.
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    359. Larson EB, Fihn SD, Kirk LM, Levinson W, Loge RV, Reynolds E, Sandy L, Schroeder S, Wenger N, Williams M. The future of general internal medicine. Report and recommendations from the Society of General Internal Medicine (SGIM) Task Force on the Domain of General Internal Medicine. J Gen Intern Med. 2004 Jan; 19(1):69-77. PMID: 14748863.
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    360. Sheffield JV, Larson EB. Postmenopausal hormones and glycemic effects. Ann Intern Med. 2003 Dec 16; 139(12):1043; author reply 1044. PMID: 14678929.
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    361. Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, Kukull WA, LaCroix AZ, McCormick W, Larson EB. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003 Oct 15; 290(15):2015-22. PMID: 14559955.
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    362. Larson EB. Review: fair evidence supports several tests in investigating fever of unknown origin. ACP J Club. 2003 Sep-Oct; 139(2):49. PMID: 12954041.
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    363. Sheffield JV, Larson EB. Update in general internal medicine. Ann Intern Med. 2003 Aug 19; 139(4):285-93. PMID: 12965984.
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    364. LaVallie DL, Gabbe SG, Grossman DC, Larson EB, Baldwin LM, Andrilla CH. Birth outcomes among American Indian/Alaska Native women with diabetes in pregnancy. J Reprod Med. 2003 Aug; 48(8):610-6. PMID: 12971141.
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    365. Bond GE, Burr R, Rice MM, McCurry SM, Graves AB, Teri L, Bowen JD, McCormick WC, Larson EB. Alcohol, aging, and cognitive performance: a cross-cultural comparison. J Aging Health. 2003 May; 15(2):371-90. PMID: 12795279.
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    366. Showstack J, Lurie N, Larson EB, Rothman AA, Hassmiller S. Primary care: the next renaissance. Ann Intern Med. 2003 Feb 04; 138(3):268-72. PMID: 12558378.
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    367. Larson EB. Medicine as a profession--back to basics: preserving the physician-patient relationship in a challenging medical marketplace. Am J Med. 2003 Feb 01; 114(2):168-72. PMID: 12586248.
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    368. Larson EB. Deferred care for patients in the emergency department. Ann Intern Med. 2002 Nov 05; 137(9):764-5. PMID: 12416950.
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    369. Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, van Belle G, Jolley L, Larson EB. Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol. 2002 Nov; 59(11):1737-46. PMID: 12433261.
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    370. Larson EB. Measuring, monitoring, and reducing medical harm from a systems perspective: a medical director's personal reflections. Acad Med. 2002 Oct; 77(10):993-1000. PMID: 12377673.
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    371. Wang L, van Belle G, Kukull WB, Larson EB. Predictors of functional change: a longitudinal study of nondemented people aged 65 and older. J Am Geriatr Soc. 2002 Sep; 50(9):1525-34. PMID: 12383150.
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    372. Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol. 2002 Jul; 59(7):1099-106. PMID: 12117357.
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    373. Phelan EA, Larson EB. "Successful aging"--where next? J Am Geriatr Soc. 2002 Jul; 50(7):1306-8. PMID: 12133032.
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    374. McCurry SM, Gibbons LE, Bond GE, Rice MM, Graves AB, Kukull WA, Teri L, Higdon R, Bowen JD, McCormick WC, Larson EB. Older adults and functional decline: a cross-cultural comparison. Int Psychogeriatr. 2002 Jun; 14(2):161-79. PMID: 12243207.
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    375. McCormick WC, Ohata CY, Uomoto J, Young HM, Graves AB, Kukull W, Teri L, Vitaliano P, Mortimer JA, McCurry SM, Bowen JD, Larson EB. Similarities and differences in attitudes toward long-term care between Japanese Americans and Caucasian Americans. J Am Geriatr Soc. 2002 Jun; 50(6):1149-55. PMID: 12110080.
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    376. Edland SD, Tobe VO, Rieder MJ, Bowen JD, McCormick W, Teri L, Schellenberg GD, Larson EB, Nickerson DA, Kukull WA. Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variants. Alzheimer Dis Assoc Disord. 2002 Jan-Mar; 16(1):1-7. PMID: 11882743.
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    377. Shadlen MF, McCormick WC, Larson EB. Research agenda for understanding Alzheimer disease in diverse populations: work group on cultural diversity, Alzheimer's association. Alzheimer Dis Assoc Disord. 2002; 16 Suppl 2:S96-S100. PMID: 12351923.
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    378. Borenstein Graves A, Mortimer JA, Bowen JD, McCormick WC, McCurry SM, Schellenberg GD, Larson EB. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E. Neurology. 2001 Oct 23; 57(8):1453-60. PMID: 11673588.
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    379. Shadlen MF, Larson EB, Gibbons LE, Rice MM, McCormick WC, Bowen J, McCurry SM, Graves AB. Ethnicity and cognitive performance among older African Americans, Japanese Americans, and Caucasians: the role of education. J Am Geriatr Soc. 2001 Oct; 49(10):1371-8. PMID: 11890499.
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    380. Rice MM, LaCroix AZ, Lampe JW, van Belle G, Kestin M, Sumitani M, Graves AB, Larson EB. Dietary soy isoflavone intake in older Japanese American women. Public Health Nutr. 2001 Oct; 4(5):943-52. PMID: 11784407.
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    381. McCormick WC, Hardy J, Kukull WA, Bowen JD, Teri L, Zitzer S, Larson EB. Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life. J Am Geriatr Soc. 2001 Sep; 49(9):1156-60. PMID: 11559373.
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    382. Sheffield JV, Larson EB, Gillock MR, Cramer DA, Kefalides PT. Update in general internal medicine. Ann Intern Med. 2001 Aug 21; 135(4):269-78. PMID: 11511142.
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    383. Moceri VM, Kukull WA, Emanual I, van Belle G, Starr JR, Schellenberg GD, McCormick WC, Bowen JD, Teri L, Larson EB. Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology. 2001 Jul; 12(4):383-9. PMID: 11416775.
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    384. McCurry SM, Gibbons LE, Uomoto JM, Thompson ML, Graves AB, Edland SD, Bowen J, McCormick WC, Larson EB. Neuropsychological test performance in a cognitively intact sample of older Japanese American adults. Arch Clin Neuropsychol. 2001 Jul; 16(5):447-59. PMID: 14590159.
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    385. Bond GE, Burr R, McCurry SM, Graves AB, Larson EB. Alcohol, aging, and cognitive performance in a cohort of Japanese Americans aged 65 and older: the Kame project. Int Psychogeriatr. 2001 Jun; 13(2):207-23. PMID: 11495395.
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    386. Larson EB. General internal medicine at the crossroads of prosperity and despair: caring for patients with chronic diseases in an aging society. Ann Intern Med. 2001 May 15; 134(10):997-1000. PMID: 11352700.
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    387. Rice MM, Larson EB, LaCroix AZ, Drinkwater BL. Diagnosing osteoporosis in Japanese American women. Am J Med. 2001 Feb 15; 110(3):241-2. PMID: 11221637.
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    388. Larson EB. Dementia in the elderly: the "silent epidemic" no more. Trans Am Clin Climatol Assoc. 2001; 112:136-46; discussion 146-8. PMID: 11413772.
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    389. Rice MM, Graves AB, McCurry SM, Gibbons LE, Bowen JD, McCormick WC, Larson EB. Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame Project. Arch Intern Med. 2000 Jun 12; 160(11):1641-9. PMID: 10847257.
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    390. Shadlen MF, Larson EB, Yukawa M. The epidemiology of Alzheimer's disease and vascular dementia in Japanese and African-American populations: the search for etiological clues. Neurobiol Aging. 2000 Mar-Apr; 21(2):171-81. PMID: 10867202.
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    391. Larson EB. An 80-year-old man with memory loss. JAMA. 2000 Feb 23; 283(8):1046-53. PMID: 10697065.
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    392. Moceri VM, Kukull WA, Emanuel I, van Belle G, Larson EB. Early-life risk factors and the development of Alzheimer's disease. Neurology. 2000 Jan 25; 54(2):415-20. PMID: 10668705.
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    393. Tsuang D, Larson EB, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz JB, Peskind ER, Lim A, Raskind MA, Thompson ML, Mirra SS, Gearing M, Schellenberg GD, Kukull W. The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series. Arch Neurol. 1999 Dec; 56(12):1489-95. PMID: 10593304.
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    394. Graves AB, Bowen JD, Rajaram L, McCormick WC, McCurry SM, Schellenberg GD, Larson EB. Impaired olfaction as a marker for cognitive decline: interaction with apolipoprotein E epsilon4 status. Neurology. 1999 Oct 22; 53(7):1480-7. PMID: 10534255.
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    395. McCurry SM, Edland SD, Teri L, Kukull WA, Bowen JD, McCormick WC, Larson EB. The cognitive abilities screening instrument (CASI): data from a cohort of 2524 cognitively intact elderly. Int J Geriatr Psychiatry. 1999 Oct; 14(10):882-8. PMID: 10521888.
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    396. Snowden M, McCormick W, Russo J, Srebnik D, Comtois K, Bowen J, Teri L, Larson EB. Validity and responsiveness of the Minimum Data Set. J Am Geriatr Soc. 1999 Aug; 47(8):1000-4. PMID: 10443863.
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    397. Gray SL, Lai KV, Larson EB. Drug-induced cognition disorders in the elderly: incidence, prevention and management. Drug Saf. 1999 Aug; 21(2):101-22. PMID: 10456379.
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    398. Teri L, Ferretti LE, Gibbons LE, Logsdon RG, McCurry SM, Kukull WA, McCormick WC, Bowen JD, Larson EB. Anxiety of Alzheimer's disease: prevalence, and comorbidity. J Gerontol A Biol Sci Med Sci. 1999 Jul; 54(7):M348-52. PMID: 10462166.
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    399. Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind ER, Raskind M, Larson EB. Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. J Am Geriatr Soc. 1999 May; 47(5):564-9. PMID: 10323650.
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    400. Tocher TM, Larson EB. Do physicians spend more time with non-English-speaking patients? J Gen Intern Med. 1999 May; 14(5):303-9. PMID: 10337040.
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    401. Edland SD, Graves AB, McCormick WC, Larson EB. Estimation and sample design in prevalence surveys of dementia. J Clin Epidemiol. 1999 May; 52(5):399-403. PMID: 10360334.
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    402. Graves AB, Rajaram L, Bowen JD, McCormick WC, McCurry SM, Larson EB. Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA: the Kame Project. J Gerontol B Psychol Sci Soc Sci. 1999 May; 54(3):S154-61. PMID: 10363046.
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    403. Shadlen MF, Larson EB, Gibbons L, McCormick WC, Teri L. Alzheimer's disease symptom severity in blacks and whites. J Am Geriatr Soc. 1999 Apr; 47(4):482-6. PMID: 10203126.
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    404. McCurry SM, Logsdon RG, Teri L, Gibbons LE, Kukull WA, Bowen JD, McCormick WC, Larson EB. Characteristics of sleep disturbance in community-dwelling Alzheimer's disease patients. J Geriatr Psychiatry Neurol. 1999; 12(2):53-9. PMID: 10483925.
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    405. Burack JH, Irby DM, Carline JD, Root RK, Larson EB. Teaching compassion and respect. Attending physicians' responses to problematic behaviors. J Gen Intern Med. 1999 Jan; 14(1):49-55. PMID: 9893091.
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    406. Shadlen MF, Larson EB. What's new in Alzheimer's disease treatment? Reasons for optimism about future pharmacologic options. Postgrad Med. 1999 Jan; 105(1):109-18. PMID: 9924498.
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    407. Larson EB. Recognition of dementia: discovering the silent epidemic. J Am Geriatr Soc. 1998 Dec; 46(12):1576-7. PMID: 9848822.
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    408. Teri L, McCurry SM, Buchner DM, Logsdon RG, LaCroix AZ, Kukull WA, Barlow WE, Larson EB. Exercise and activity level in Alzheimer's disease: a potential treatment focus. J Rehabil Res Dev. 1998 Oct; 35(4):411-9. PMID: 10220219.
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    409. Graves AB, Rosner D, Echeverria D, Mortimer JA, Larson EB. Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease. Occup Environ Med. 1998 Sep; 55(9):627-33. PMID: 9861186.
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    410. Logsdon RG, Teri L, McCurry SM, Gibbons LE, Kukull WA, Larson EB. Wandering: a significant problem among community-residing individuals with Alzheimer's disease. J Gerontol B Psychol Sci Soc Sci. 1998 Sep; 53(5):P294-9. PMID: 9750566.
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    411. Liu HC, Fuh JL, Wang SJ, Liu CY, Larson EB, Lin KN, Wang HC, Chou P, Wu ZA, Lin CH, Wang PN, Teng EL. Prevalence and subtypes of dementia in a rural Chinese population. Alzheimer Dis Assoc Disord. 1998 Sep; 12(3):127-34. PMID: 9772013.
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    412. Hu Q, Kukull WA, Bressler SL, Gray MD, Cam JA, Larson EB, Martin GM, Deeb SS. The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. Hum Genet. 1998 Sep; 103(3):295-303. PMID: 9799084.
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    413. Craft S, Teri L, Edland SD, Kukull WA, Schellenberg G, McCormick WC, Bowen JD, Larson EB. Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease. Neurology. 1998 Jul; 51(1):149-53. PMID: 9674794.
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    414. Larson EB, McCurry SM, Graves AB, Bowen JD, Rice MM, McCormick WC, Zee N, Homma A, Imai Y, White L, Masaki K, Petrovitch H, Ross W, Yamada M, Mimori Y, Sasaki H. Standardization of the clinical diagnosis of the dementia syndrome and its subtypes in a cross-national study: the Ni-Hon-Sea experience. J Gerontol A Biol Sci Med Sci. 1998 Jul; 53(4):M313-9. PMID: 18314572.
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    415. Larson EB. New drug treatments for Alzheimer disease. Arch Intern Med. 1998 May 11; 158(9):941-2. PMID: 9588426.
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    416. Larson EB. Successful aging. An overview. West J Med. 1997 Oct; 167(4):204-5. PMID: 9348748.
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    417. Rice MM, Graves AB, McCurry SM, Larson EB. Estrogen replacement therapy and cognitive function in postmenopausal women without dementia. Am J Med. 1997 Sep 22; 103(3A):26S-35S. PMID: 9344404.
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    418. Every NR, Parsons LS, Fihn SD, Larson EB, Maynard C, Hallstrom AP, Martin JS, Weaver WD. Long-term outcome in acute myocardial infarction patients admitted to hospitals with and without on-site cardiac catheterization facilities. MITI Investigators. Myocardial Infarction Triage and Intervention. Circulation. 1997 Sep 16; 96(6):1770-5. PMID: 9323060.
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    419. O'Meara ES, Kukull WA, Sheppard L, Bowen JD, McCormick WC, Teri L, Pfanschmidt M, Thompson JD, Schellenberg GD, Larson EB. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype. Am J Epidemiol. 1997 Sep 01; 146(5):373-84. PMID: 9290497.
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    420. Sheffield JV, Larson EB. Update in general internal medicine. Ann Intern Med. 1997 Jul 01; 127(1):43-51. PMID: 9214252.
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    421. Larson EB. How can clinicians incorporate research advances into practice? J Gen Intern Med. 1997 Apr; 12 Suppl 2:S20-4. PMID: 9127240.
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    422. Bowen J, Teri L, Kukull W, McCormick W, McCurry SM, Larson EB. Progression to dementia in patients with isolated memory loss. Lancet. 1997 Mar 15; 349(9054):763-5. PMID: 9074575.
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    423. van Belle G, Gibson K, Nochlin D, Sumi M, Larson EB. Counting plaques and tangles in Alzheimer's disease: concordance of technicians and pathologists. J Neurol Sci. 1997 Feb 12; 145(2):141-6. PMID: 9094041.
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    424. O'Meara ES, Kukull WA, Schellenberg GD, Bowen JD, McCormick WC, Teri L, Pfanschmidt M, Thompson JD, Larson EB. Alzheimer's disease and history of blood transfusion by apolipoprotein-E genotype. Neuroepidemiology. 1997; 16(2):86-93. PMID: 9057170.
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    425. Larson EB, Edwards JK, O'Meara E, Nochlin D, Sumi SM. Neuropathologic diagnostic outcomes from a cohort of outpatients with suspected dementia. J Gerontol A Biol Sci Med Sci. 1996 Nov; 51(6):M313-8. PMID: 8914504.
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    426. Graves AB, Larson EB, Edland SD, Bowen JD, McCormick WC, McCurry SM, Rice MM, Wenzlow A, Uomoto JM. Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington state. The Kame Project. Am J Epidemiol. 1996 Oct 15; 144(8):760-71. PMID: 8857825.
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    427. Kukull WA, Schellenberg GD, Bowen JD, McCormick WC, Yu CE, Teri L, Thompson JD, O'Meara ES, Larson EB. Apolipoprotein E in Alzheimer's disease risk and case detection: a case-control study. J Clin Epidemiol. 1996 Oct; 49(10):1143-8. PMID: 8826994.
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    428. Sheffield JV, Larson EB. General internal medicine update. Information clinicians and teachers need to know. J Gen Intern Med. 1996 Oct; 11(10):613-21. PMID: 8945693.
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    429. Bowen JD, Malter AD, Sheppard L, Kukull WA, McCormick WC, Teri L, Larson EB. Predictors of mortality in patients diagnosed with probable Alzheimer's disease. Neurology. 1996 Aug; 47(2):433-9. PMID: 8757016.
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    430. Graves AB, Mortimer JA, Larson EB, Wenzlow A, Bowen JD, McCormick WC. Head circumference as a measure of cognitive reserve. Association with severity of impairment in Alzheimer's disease. Br J Psychiatry. 1996 Jul; 169(1):86-92. PMID: 8818374.
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    431. McCormick WC, Uomoto J, Young H, Graves AB, Vitaliano P, Mortimer JA, Edland SD, Larson EB. Attitudes toward use of nursing homes and home care in older Japanese-Americans. J Am Geriatr Soc. 1996 Jul; 44(7):769-77. PMID: 8675923.
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    432. Tsuang D, Kukull W, Sheppard L, Barnhart RL, Peskind E, Edland SD, Schellenberg G, Raskind M, Larson EB. Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples. J Am Geriatr Soc. 1996 Jun; 44(6):704-7. PMID: 8642164.
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    433. Laya MB, Larson EB, Taplin SH, White E. Effect of estrogen replacement therapy on the specificity and sensitivity of screening mammography. J Natl Cancer Inst. 1996 May 15; 88(10):643-9. PMID: 8627640.
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    434. Malter AD, Larson EB, Urban N, Deyo RA. Cost-effectiveness of lumbar discectomy for the treatment of herniated intervertebral disc. Spine (Phila Pa 1976). 1996 May 01; 21(9):1048-54; discussion 1055. PMID: 8724089.
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    435. Boiko PE, Koepsell TD, Larson EB, Wagner EH. Skin cancer diagnosis in a primary care setting. J Am Acad Dermatol. 1996 Apr; 34(4):608-11. PMID: 8601649.
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    436. Lautenschlager NT, Cupples LA, Rao VS, Auerbach SA, Becker R, Burke J, Chui H, Duara R, Foley EJ, Glatt SL, Green RC, Jones R, Karlinsky H, Kukull WA, Kurz A, Larson EB, Martelli K, Sadovnick AD, Volicer L, Waring SC, Growdon JH, Farrer LA. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old? Neurology. 1996 Mar; 46(3):641-50. PMID: 8618660.
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    437. Jarvik G, Larson EB, Goddard K, Schellenberg GD, Wijsman EM. Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. Am J Hum Genet. 1996 Jan; 58(1):191-200. PMID: 8554056.
      Citations:    
    438. Larson EB, Kukull WA. Prevention of Alzheimer disease: a perspective based on successes in the prevention of other chronic diseases. Alzheimer Dis Assoc Disord. 1996; 10 Suppl 1:9-12. PMID: 8876781.
      Citations:    
    439. Speck CE, Kukull WA, Brenner DE, Bowen JD, McCormick WC, Teri L, Pfanschmidt ML, Thompson JD, Larson EB. History of depression as a risk factor for Alzheimer's disease. Epidemiology. 1995 Jul; 6(4):366-9. PMID: 7548342.
      Citations:    
    440. Snowden MB, Bowen JD, Hughes J, Larson EB. Study of Alzheimer's dementia patients with parkinsonian features. J Geriatr Psychiatry Neurol. 1995 Jul; 8(3):154-8. PMID: 7576038.
      Citations:    
    441. Kukull WA, Larson EB, Bowen JD, McCormick WC, Teri L, Pfanschmidt ML, Thompson JD, O'Meara ES, Brenner DE, van Belle G. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. Am J Epidemiol. 1995 Jun 01; 141(11):1059-71; discussion 1072-9. PMID: 7771442.
      Citations:    
    442. Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 1995 Jun; 45(6):1092-6. PMID: 7783869.
      Citations:    
    443. McCormick WC, Kukull WA, van Belle G, Bowen JD, Teri L, Larson EB. The effect of diagnosing Alzheimer's disease on frequency of physician visits: a case-control study. J Gen Intern Med. 1995 Apr; 10(4):187-93. PMID: 7790979.
      Citations:    
    444. Bradley KA, Curry SJ, Koepsell TD, Larson EB. Primary and secondary prevention of alcohol problems: U.S. internist attitudes and practices. J Gen Intern Med. 1995 Feb; 10(2):67-72. PMID: 7730941.
      Citations:    
    445. Alexander EM, Wagner EH, Buchner DM, Cain KC, Larson EB. Do surgical brain lesions present as isolated dementia? A population-based study. J Am Geriatr Soc. 1995 Feb; 43(2):138-43. PMID: 7836637.
      Citations:    
    446. Fuh JL, Teng EL, Lin KN, Larson EB, Wang SJ, Liu CY, Chou P, Kuo BI, Liu HC. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening tool for dementia for a predominantly illiterate Chinese population. Neurology. 1995 Jan; 45(1):92-6. PMID: 7824143.
      Citations:    
    447. Teri L, McCurry SM, Edland SD, Kukull WA, Larson EB. Cognitive decline in Alzheimer's disease: a longitudinal investigation of risk factors for accelerated decline. J Gerontol A Biol Sci Med Sci. 1995 Jan; 50A(1):M49-55. PMID: 7814789.
      Citations:    
    448. Kukull WA, Larson EB, Teri L, Bowen J, McCormick W, Pfanschmidt ML. The Mini-Mental State Examination score and the clinical diagnosis of dementia. J Clin Epidemiol. 1994 Sep; 47(9):1061-7. PMID: 7730909.
      Citations:    
    449. Liu HC, Chou P, Lin KN, Wang SJ, Fuh JL, Lin HC, Liu CY, Wu GS, Larson EB, White LR, et al. Assessing cognitive abilities and dementia in a predominantly illiterate population of older individuals in Kinmen. Psychol Med. 1994 Aug; 24(3):763-70. PMID: 7991758.
      Citations:    
    450. Brenner DE, Kukull WA, Stergachis A, van Belle G, Bowen JD, McCormick WC, Teri L, Larson EB. Postmenopausal estrogen replacement therapy and the risk of Alzheimer's disease: a population-based case-control study. Am J Epidemiol. 1994 Aug 01; 140(3):262-7. PMID: 8030629.
      Citations:    
    451. Kukull WA, Brenner DE, Speck CE, Nochlin D, Bowen J, McCormick W, Teri L, Pfanschmidt ML, Larson EB. Causes of death associated with Alzheimer disease: variation by level of cognitive impairment before death. J Am Geriatr Soc. 1994 Jul; 42(7):723-6. PMID: 8014346.
      Citations:    
    452. Kent DL, Haynor DR, Longstreth WT, Larson EB. The clinical efficacy of magnetic resonance imaging in neuroimaging. Ann Intern Med. 1994 May 15; 120(10):856-71. PMID: 7818632.
      Citations:    
    453. Bradley KA, Larson EB. Training physicians to help patients who drink too much. J Gen Intern Med. 1994 May; 9(5):296-8. PMID: 8046535.
      Citations:    
    454. McCormick WC, Kukull WA, van Belle G, Bowen JD, Teri L, Larson EB. Symptom patterns and comorbidity in the early stages of Alzheimer's disease. J Am Geriatr Soc. 1994 May; 42(5):517-21. PMID: 8176147.
      Citations:    
    455. Hinds TR, Kukull WA, Van Belle G, Schellenberg GD, Villacres EC, Larson EB. Relationship between serum alpha 1-antichymotrypsin and Alzheimer's disease. Neurobiol Aging. 1994 Jan-Feb; 15(1):21-7. PMID: 8159260.
      Citations:    
    456. Graves AB, Larson EB, White LR, Teng EL, Homma A. Opportunities and challenges in international collaborative epidemiologic research of dementia and its subtypes: studies between Japan and the U.S. Int Psychogeriatr. 1994; 6(2):209-23. PMID: 7865708.
      Citations:    
    457. Bradley KA, Donovan DM, Larson EB. How much is too much? Advising patients about safe levels of alcohol consumption. Arch Intern Med. 1993 Dec 27; 153(24):2734-40. PMID: 8257248.
      Citations:    
    458. Every NR, Larson EB, Litwin PE, Maynard C, Fihn SD, Eisenberg MS, Hallstrom AP, Martin JS, Weaver WD. The association between on-site cardiac catheterization facilities and the use of coronary angiography after acute myocardial infarction. Myocardial Infarction Triage and Intervention Project Investigators. N Engl J Med. 1993 Aug 19; 329(8):546-51. PMID: 8336755.
      Citations:    
    459. Atkins D, Psaty BM, Koepsell TD, Longstreth WT, Larson EB. Cholesterol reduction and the risk for stroke in men. A meta-analysis of randomized, controlled trials. Ann Intern Med. 1993 Jul 15; 119(2):136-45. PMID: 8305001.
      Citations:    
    460. Bowen JD, Larson EB. Drug-induced cognitive impairment. Defining the problem and finding solutions. Drugs Aging. 1993 Jul-Aug; 3(4):349-57. PMID: 8369594.
      Citations:    
    461. Larson EB. Adverse drug effects: the harder we look, the more we find. J Gen Intern Med. 1993 Jun; 8(6):342-3. PMID: 8320580.
      Citations:    
    462. Grossmann A, Kukull WA, Jinneman JC, Bird TD, Villacres EC, Larson EB, Rabinovitch PS. Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome. Neurobiol Aging. 1993 Mar-Apr; 14(2):177-85. PMID: 8098135.
      Citations:    
    463. Brenner DE, Kukull WA, van Belle G, Bowen JD, McCormick WC, Teri L, Larson EB. Relationship between cigarette smoking and Alzheimer's disease in a population-based case-control study. Neurology. 1993 Feb; 43(2):293-300. PMID: 8437692.
      Citations:    
    464. Larson EB. Illnesses causing dementia in the very elderly. N Engl J Med. 1993 Jan 21; 328(3):203-5. PMID: 8417387.
      Citations:    
    465. Weingarten S, Kleinman M, Elperin L, Larson EB. The effectiveness of cerebral imaging in the diagnosis of chronic headache. Arch Intern Med. 1992 Dec; 152(12):2457-62. PMID: 1456857.
      Citations:    
    466. Elward KS, Wagner EH, Larson EB. Participation by sedentary elderly persons in an exercise promotion session. Fam Med. 1992 Nov-Dec; 24(8):607-12. PMID: 1426730.
      Citations:    
    467. Logsdon RG, Teri L, Larson EB. Driving and Alzheimer's disease. J Gen Intern Med. 1992 Nov-Dec; 7(6):583-8. PMID: 1453241.
      Citations:    
    468. Atkins D, Larson EB. X-rays for sinusitis: a matter of which or when? J Gen Intern Med. 1992 Sep-Oct; 7(5):566. PMID: 1403217.
      Citations:    
    469. Larson EB, Ramsbottom-Lucier M. Talking to patients. J Gen Intern Med. 1992 Jul-Aug; 7(4):464-5. PMID: 1506956.
      Citations:    
    470. Haynes RB, Sandler RS, Larson EB, Pater JL, Yatsu FM. A critical appraisal of ticlopidine, a new antiplatelet agent. Effectiveness and clinical indications for prophylaxis of atherosclerotic events. Arch Intern Med. 1992 Jul; 152(7):1376-80. PMID: 1627017.
      Citations:    
    471. Kent DL, Haynor DR, Larson EB, Deyo RA. Diagnosis of lumbar spinal stenosis in adults: a metaanalysis of the accuracy of CT, MR, and myelography. AJR Am J Roentgenol. 1992 May; 158(5):1135-44. PMID: 1533084.
      Citations:    
    472. Larson EB. Academic mentorship: an important ingredient for our survival. J Gen Intern Med. 1992 Mar-Apr; 7(2):255. PMID: 1487779.
      Citations:    
    473. Welch HG, Walsh JS, Larson EB. The cost of institutional care in Alzheimer's disease: nursing home and hospital use in a prospective cohort. J Am Geriatr Soc. 1992 Mar; 40(3):221-4. PMID: 1538039.
      Citations:    
    474. Kukull WA, Hinds TR, Schellenberg GD, van Belle G, Larson EB. Increased platelet membrane fluidity as a diagnostic marker for Alzheimer's disease: a test in population-based cases and controls. Neurology. 1992 Mar; 42(3 Pt 1):607-14. PMID: 1549223.
      Citations:    
    475. Kent DL, Larson EB. Disease, level of impact, and quality of research methods. Three dimensions of clinical efficacy assessment applied to magnetic resonance imaging. Invest Radiol. 1992 Mar; 27(3):245-54. PMID: 1551777.
      Citations:    
    476. Elward K, Larson EB. Benefits of exercise for older adults. A review of existing evidence and current recommendations for the general population. Clin Geriatr Med. 1992 Feb; 8(1):35-50. PMID: 1576579.
      Citations:    
    477. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: dementia and Alzheimer's disease. Annu Rev Public Health. 1992; 13:431-49. PMID: 1599598.
      Citations:    
    478. Buchner DM, Beresford SA, Larson EB, LaCroix AZ, Wagner EH. Effects of physical activity on health status in older adults. II. Intervention studies. Annu Rev Public Health. 1992; 13:469-88. PMID: 1599599.
      Citations:    
    479. Wagner EH, LaCroix AZ, Buchner DM, Larson EB. Effects of physical activity on health status in older adults. I: Observational studies. Annu Rev Public Health. 1992; 13:451-68. PMID: 1534661.
      Citations:    
    480. Schellenberg GD, Anderson L, O'dahl S, Wisjman EM, Sadovnick AD, Ball MJ, Larson EB, Kukull WA, Martin GM, Roses AD, et al. APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease. Am J Hum Genet. 1991 Sep; 49(3):511-7. PMID: 1679288.
      Citations:    
    481. Uhlmann RF, Larson EB. Effect of education on the mini-mental state examination as a screening test for dementia. J Am Geriatr Soc. 1991 Sep; 39(9):876-80. PMID: 1885862.
      Citations:    
    482. Ramsey PG, Carline JD, Inui TS, Larson EB, LoGerfo JP, Norcini JJ, Wenrich MD. Changes over time in the knowledge base of practicing internists. JAMA. 1991 Aug 28; 266(8):1103-7. PMID: 1865543.
      Citations:    
    483. Larson EB. Geriatric medicine. JAMA. 1991 Jun 19; 265(23):3125-6. PMID: 2041122.
      Citations:    
    484. Larson EB. Exercise, functional decline and frailty. J Am Geriatr Soc. 1991 Jun; 39(6):635-6. PMID: 2037759.
      Citations:    
    485. Edwards JK, Larson EB, Hughes JP, Kukull WA. Are there clinical and epidemiological differences between familial and non-familial Alzheimer's disease? J Am Geriatr Soc. 1991 May; 39(5):477-83. PMID: 2022799.
      Citations:    
    486. Uhlmann RF, Larson EB, Koepsell TD, Rees TS, Duckert LG. Visual impairment and cognitive dysfunction in Alzheimer's disease. J Gen Intern Med. 1991 Mar-Apr; 6(2):126-32. PMID: 2023019.
      Citations:    
    487. Ellsworth AJ, Meyer EF, Larson EB. Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier. West J Med. 1991 Mar; 154(3):289-93. PMID: 2028586; PMCID: PMC1002747.
      Citations:    
    488. McCormick WC, Larson EB. Pragmatism and probabilities in dementia. Hosp Pract (Off Ed). 1990 Dec 15; 25(12):93-100, 103-6, 113-4. PMID: 2123215.
      Citations:    
    489. Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB, Raskind M. A case-control study of Alzheimer's disease. Ann Neurol. 1990 Dec; 28(6):766-74. PMID: 2285263.
      Citations:    
    490. Larson EB, Kukull WA, Teri L, McCormick W, Pfanschmidt M, van Belle G, Sumi M. University of Washington Alzheimer's Disease Patient Registry (ADPR): 1987-1988. Aging (Milano). 1990 Dec; 2(4):404-8. PMID: 2094380.
      Citations:    
    491. Walsh JS, Welch HG, Larson EB. Survival of outpatients with Alzheimer-type dementia. Ann Intern Med. 1990 Sep 15; 113(6):429-34. PMID: 2386336.
      Citations:    
    492. Kukull WA, Larson EB, Reifler BV, Lampe TH, Yerby MS, Hughes JP. The validity of 3 clinical diagnostic criteria for Alzheimer's disease. Neurology. 1990 Sep; 40(9):1364-9. PMID: 2392219.
      Citations:    
    493. Larson EB, Hughes JP, Kukull WA. New data gathering, instrument selection, and evaluation of existing information for determining entry. Aging (Milano). 1990 Jun; 2(2):215-22. PMID: 2095863.
      Citations:    
    494. Teri L, Hughes JP, Larson EB. Cognitive deterioration in Alzheimer's disease: behavioral and health factors. J Gerontol. 1990 Mar; 45(2):P58-63. PMID: 2313049.
      Citations:    
    495. Larson EB. Medical technologies: restraint or discretion? J Gen Intern Med. 1990 Mar-Apr; 5(2):178-9. PMID: 2313409.
      Citations:    
    496. Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB, Raskind M. The association between head trauma and Alzheimer's disease. Am J Epidemiol. 1990 Mar; 131(3):491-501. PMID: 2405648.
      Citations:    
    497. Kukull WA, Larson EB, Reifler BV, Lampe TH, Yerby M, Hughes J. Interrater reliability of Alzheimer's disease diagnosis. Neurology. 1990 Feb; 40(2):257-60. PMID: 2300244.
      Citations:    
    498. Fihn SD, Larson EB, Friedman RH, Moskowitz MA. Ambulatory care research in the VA: present status and recommendations for the future. Acad Med. 1989 Oct; 64(10 Suppl):S35-43. PMID: 2789613.
      Citations:    
    499. Carline JD, Inui TS, Larson EB, LoGerfo JP, Ramsey PG. The knowledge base of certified internists. Relationships to training, practice type, and other physician characteristics. Arch Intern Med. 1989 Oct; 149(10):2311-3. PMID: 2802895.
      Citations:    
    500. Bowen JD, Larson EB. Understanding the dizzy patient. A challenge to primary care physicians. J Fam Pract. 1989 Jul; 29(1):30-2. PMID: 2738547.
      Citations:    
    501. Kukull WA, Larson EB. Distinguishing Alzheimer's disease from other dementias. Questionnaire responses of close relatives and autopsy results. J Am Geriatr Soc. 1989 Jun; 37(6):521-7. PMID: 2654258.
      Citations:    
    502. Ramsey PG, Carline JD, Inui TS, Larson EB, LoGerfo JP, Wenrich MD. Predictive validity of certification by the American Board of Internal Medicine. Ann Intern Med. 1989 May 01; 110(9):719-26. PMID: 2930109.
      Citations:    
    503. Uhlmann RF, Larson EB, Rees TS, Koepsell TD, Duckert LG. Relationship of hearing impairment to dementia and cognitive dysfunction in older adults. JAMA. 1989 Apr 07; 261(13):1916-9. PMID: 2926927.
      Citations:    
    504. Uhlmann RF, Teri L, Rees TS, Mozlowski KJ, Larson EB. Impact of mild to moderate hearing loss on mental status testing. Comparability of standard and written Mini-Mental State Examinations. J Am Geriatr Soc. 1989 Mar; 37(3):223-8. PMID: 2918192.
      Citations:    
    505. VanArsdel PP, Larson EB. Diagnostic tests for patients with suspected allergic disease. Utility and limitations. Ann Intern Med. 1989 Feb 15; 110(4):304-12. PMID: 2643916.
      Citations:    
    506. Hughes JP, van Belle G, Kukull W, Larson EB, Teri L. On the uses of registries for Alzheimer disease. Alzheimer Dis Assoc Disord. 1989; 3(4):205-17. PMID: 2688699.
      Citations:    
    507. Larson EB. Attending to the needs of elderly patients. J Am Geriatr Soc. 1988 Aug; 36(8):753-4. PMID: 3403880.
      Citations:    
    508. Buchner DM, Larson EB. Transfer bias and the association of cognitive impairment with falls. J Gen Intern Med. 1988 May-Jun; 3(3):254-9. PMID: 3259981.
      Citations:    
    509. Kent DL, Larson EB. Diagnostic technology assessments: problems and prospects. Ann Intern Med. 1988 May; 108(5):759-61. PMID: 3358576.
      Citations:    
    510. Krueger DW, Larson EB. Recurrent fever of unknown origin, coma, and meningismus due to a leaking craniopharyngioma. Am J Med. 1988 Mar; 84(3 Pt 1):543-5. PMID: 3348255.
      Citations:    
    511. Kent DL, Larson EB. Magnetic resonance imaging of the brain and spine. Is clinical efficacy established after the first decade? Ann Intern Med. 1988 Mar; 108(3):402-24. PMID: 3277514.
      Citations:    
    512. Teri L, Larson EB, Reifler BV. Behavioral disturbance in dementia of the Alzheimer's type. J Am Geriatr Soc. 1988 Jan; 36(1):1-6. PMID: 3335725.
      Citations:    
    513. Ellsworth AJ, Larson EB, Strickland D. A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis. Am J Med. 1987 Dec; 83(6):1024-30. PMID: 3332564.
      Citations:    
    514. Larson EB. Competition and technology's consort. Am J Med. 1987 Aug; 83(2):340-2. PMID: 3618634.
      Citations:    
    515. Larson EB, Kukull WA, Buchner D, Reifler BV. Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Intern Med. 1987 Aug; 107(2):169-73. PMID: 2886086.
      Citations:    
    516. Buchner DM, Larson EB, White RF. Influenza vaccination in community elderly. A controlled trial of postcard reminders. J Am Geriatr Soc. 1987 Aug; 35(8):755-60. PMID: 3301990.
      Citations:    
    517. Nardone DA, Wallack P, Martinez-Weber C, Larson EB, Goldstein BJ, Mushlin AI. Letters to the editors. J Gen Intern Med. 1987 Jul; 2(4):288-9. PMID: 27519732.
      Citations:    
    518. Luthy DA, Shy KK, van Belle G, Larson EB, Hughes JP, Benedetti TJ, Brown ZA, Effer S, King JF, Stenchever MA. A randomized trial of electronic fetal monitoring in preterm labor. Obstet Gynecol. 1987 May; 69(5):687-95. PMID: 3554055.
      Citations:    
    519. Buchner DM, Larson EB. Falls and fractures in patients with Alzheimer-type dementia. JAMA. 1987 Mar 20; 257(11):1492-5. PMID: 3820464.
      Citations:    
    520. Shapiro MF, Larson EB. Funding for medical care research. J Gen Intern Med. 1987 Mar-Apr; 2(2):113-8. PMID: 3559775.
      Citations:    
    521. Larson EB, Bruce RA. Health benefits of exercise in an aging society. Arch Intern Med. 1987 Feb; 147(2):353-6. PMID: 3545119.
      Citations:    
    522. Reifler BV, Larson EB, Teri L. An outpatient geriatric psychiatry assessment and treatment service. Clin Geriatr Med. 1987 Feb; 3(1):203-9. PMID: 3815245.
      Citations:    
    523. Uhlmann RF, Larson EB, Buchner DM. Correlations of Mini-Mental State and modified Dementia Rating Scale to measures of transitional health status in dementia. J Gerontol. 1987 Jan; 42(1):33-6. PMID: 3794193.
      Citations:    
    524. Larson EB, Bruce RA. Exercise and aging. Ann Intern Med. 1986 Nov; 105(5):783-5. PMID: 3767154.
      Citations:    
    525. Larson EB, Buchner DM, Uhlmann RF, Reifler BV. Caring for elderly patients with dementia. Arch Intern Med. 1986 Oct; 146(10):1909-10. PMID: 3767532.
      Citations:    
    526. Larson EB, Reifler BV, Sumi SM, Canfield CG, Chinn NM. Diagnostic tests in the evaluation of dementia. A prospective study of 200 elderly outpatients. Arch Intern Med. 1986 Oct; 146(10):1917-22. PMID: 3767535.
      Citations:    
    527. Fletcher RH, Burack RC, Larson EB, Lewis CE, Noren JJ, Rabin DL, Stokes J, Scatarige CS, Reid Y. Interrelationships of general internal medicine and preventive/community medicine. Am J Prev Med. 1986 Sep-Oct; 2(5):285-9. PMID: 3453193.
      Citations:    
    528. Larson EB. Practice-based research in geriatrics by general internists. J Gen Intern Med. 1986 Jul-Aug; 1(4 Suppl):S42-4. PMID: 3772609.
      Citations:    
    529. Larson EB, Lo B, Williams ME. Evaluation and care of elderly patients with dementia. J Gen Intern Med. 1986 Mar-Apr; 1(2):116-26. PMID: 3534170.
      Citations:    
    530. Uhlmann RF, Larson EB, Koepsell TD. Hearing impairment and cognitive decline in senile dementia of the Alzheimer's type. J Am Geriatr Soc. 1986 Mar; 34(3):207-10. PMID: 3950288.
      Citations:    
    531. Yerby MS, Sundsten JW, Larson EB, Wu SA, Sumi SM. A new method of measuring brain atrophy: the effect of aging in its application for diagnosing dementia. Neurology. 1985 Sep; 35(9):1316-20. PMID: 4022378.
      Citations:    
    532. Heller TA, Larson EB, LoGerfo JP. Quality of ambulatory care of the elderly: an analysis of five conditions. J Am Geriatr Soc. 1984 Nov; 32(11):782-8. PMID: 6501764.
      Citations:    
    533. Fihn SD, Larson EB, Nelp WB, Rudd TG, Gerber FH. Should single-phase radionuclide bone imaging be used in suspected osteomyelitis? J Nucl Med. 1984 Oct; 25(10):1080-8. PMID: 6481459.
      Citations:    
    534. Larson EB, Reifler BV, Featherstone HJ, English DR. Dementia in elderly outpatients: a prospective study. Ann Intern Med. 1984 Mar; 100(3):417-23. PMID: 6696360.
      Citations:    
    535. Breen AR, Larson EB, Reifler BV, Vitaliano PP, Lawrence GL. Cognitive performance and functional competence in coexisting dementia and depression. J Am Geriatr Soc. 1984 Feb; 32(2):132-7. PMID: 6693699.
      Citations:    
    536. Fihn SD, Larson EB, Rudd TR, Nelp WB. Clinical use of radionuclide bone imaging in a university medical center. JAMA. 1982 Jul 23; 248(4):439-42. PMID: 7087143.
      Citations:    
    537. Larson EB, Mack LA, Watts B, Cromwell LD. Computed tomography in patients with psychiatric illnesses: advantage of a "rule-in" approach. Ann Intern Med. 1981 Sep; 95(3):360-4. PMID: 7271095.
      Citations:    
    538. Larson EB, Stratton JR, Pearlman AS. Selective use of two-dimensional echocardiography in stroke syndromes. Ann Intern Med. 1981 Jul; 95(1):112-4. PMID: 7247112.
      Citations:    
    539. Fihn SD, Larson EB. Relapsing Fever revisited. West J Med. 1981 Mar; 134(3):263-4. PMID: 18748834.
      Citations:    
    540. Fihn S, Larson EB. Tick-borne relapsing fever in the Pacific Northwest: an underdiagnosed illness? West J Med. 1980 Sep; 133(3):203-9. PMID: 7415171.
      Citations:    
    541. Larson EB, Omenn GS, Lewis H. Diagnostic evaluation of headache. Impact of computerized tomography and cost-effectiveness. JAMA. 1980 Jan 25; 243(4):359-62. PMID: 6766193.
      Citations:    
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