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Denise Boudreau, PhD

TitleSenior Investigator
InstitutionKaiser Permanente Washington
DepartmentKaiser Permanente Washington Health Research Institute
Address1730 Minor Ave
Seattle WA 98101
ORCID ORCID Icon0000-0003-4300-4901 Additional info
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    Collapse Overview 
    Collapse overview
    Pharmacoepidemiologist Denise Boudreau, PhD, plays an integral role in Kaiser Permanente Washington Health Research Institute (KPWHRI) investigations into medication safety and cost-effectiveness of pharmaceuticals. Known at the Institute for her expertise in pharmacoepidemiologic methods, she has diverse experience spanning pharmacies, classrooms, and research institutions.

    Dr. Boudreau worked as a pharmacist before earning her Masters in Pharmacy Administration (1996) from the University of Rhode Island and PhD from the Pharmaceutical Outcomes and Research Policy Program (2002) at the University of Washington (UW). She began her career at KPWHRI in 2003. Dr. Boudreau is also a affiliate professor in the UW School of Pharmacy and UW Department of Epidemiology where she teaches the graduate pharmacoepidemiology course and mentors students.

    Dr. Boudreau is adept at using electronic health records for research purposes and has expertise in observational study design, managed care, drug safety, and economic evaluation. She brings an in-depth working knowledge of Kaiser Permanente Washington pharmacy data and practices to her research, which ranges from cancer to women’s health to opioid medication safety. She has been the Health Care Systems Research Network Steering Committee Representative for the Food and Drug Administration Mini Sentinel Initiative for the past eight years and was extensively involved in developing both the data and methods for signal detection of adverse events.

    Dr. Boudreau has pioneered work in the field of medication safety as it relates to cancer risk and cancer outcomes as well as studying the medication management of comorbidities among cancer survivors. For the last five years, she has dedicated her studies to helping solve the opioid epidemic in the U.S. She is currently leading two large multisite studies of the risk of opioid misuse, abuse, and addiction with long-term opioid therapy and the relation between opioid use during pregnancy and risk of birth defects. She is a co-investigator on a clinical trial to improve treatment of opioid use disorder and a co-investigator on an observational study to better understand what leads to successful tapering or discontinuing of opioids among long-term, high dose users.

    Dr. Boudreau's research has been exhibited internationally at conferences such as the International Society for Pharmacoepidemiology, the International Society for Pharmacoeconomics and Outcomes Research, and the Congress of Epidemiology. Her professional memberships include the International Society for Pharmacoepidemiology and the International Society for Pharmacoeconomics and Outcomes Research. She retains her pharmacy license in Washington state.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bagley SM, Chavez L, Braciszewski JM, Akolsile M, Boudreau DM, Lapham G, Campbell CI, Bart G, Yarborough BJH, Samet JH, Saxon AJ, Rossom RC, Binswanger IA, Murphy MT, Glass JE, Bradley KA, PROUD Collaborative. Receipt of medications for opioid use disorder among youth engaged in primary care: data from 6 health systems. Addict Sci Clin Pract. 2021 07 07; 16(1):46. PMID: 34233750; PMCID: PMC8262000.
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    2. Wartko PD, Boudreau DM, Turner JA, Cook AJ, Wellman RD, Fujii MM, Garcia RC, Moser KA, Sullivan MD. STRategies to Improve Pain and Enjoy life (STRIPE): Protocol for a pragmatic randomized trial of pain coping skills training and opioid medication taper guidance for patients on long-term opioid therapy. Contemp Clin Trials. 2021 Jul 01; 106499. PMID: 34217889.
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    3. Pocobelli G, Dublin S, Bobb JF, Albertson-Junkans L, Andrade S, Cheetham TC, Salgado G, Griffin MR, Raebel MA, Smith D, Li DK, Pawloski PA, Toh S, Taylor L, Hua W, Horn P, Trinidad JP, Boudreau DM. Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014. Pharmacoepidemiol Drug Saf. 2021 Jun 24. PMID: 34169607.
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    4. Tsui JI, Akosile MA, Lapham GT, Boudreau DM, Johnson EA, Bobb JF, Binswanger IA, Yarborough BJH, Glass JE, Rossom RC, Murphy MT, Cunningham CO, Arnsten JH, Thakral M, Saxon AJ, Merrill JO, Samet JH, Bart GB, Campbell CI, Loree AM, Silva A, Stotts AL, Ahmedani B, Braciszewski JM, Hechter RC, Northrup TF, Horigian VE, Bradley KA. Prevalence and Medication Treatment of Opioid Use Disorder Among Primary Care Patients with Hepatitis C and HIV. J Gen Intern Med. 2021 04; 36(4):930-937. PMID: 33569735; PMCID: PMC8041979.
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    5. Campbell CI, Saxon AJ, Boudreau DM, Wartko PD, Bobb JF, Lee AK, Matthews AG, McCormack J, Liu DS, Addis M, Altschuler A, Samet JH, LaBelle CT, Arnsten J, Caldeiro RM, Borst DT, Stotts AL, Braciszewski JM, Szapocznik J, Bart G, Schwartz RP, McNeely J, Liebschutz JM, Tsui JI, Merrill JO, Glass JE, Lapham GT, Murphy SM, Weinstein ZM, Yarborough BJH, Bradley KA. PRimary Care Opioid Use Disorders treatment (PROUD) trial protocol: a pragmatic, cluster-randomized implementation trial in primary care for opioid use disorder treatment. Addict Sci Clin Pract. 2021 01 31; 16(1):9. PMID: 33517894; PMCID: PMC7849121.
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    6. Fuller CC, Hua W, Leonard CE, Mosholder A, Carnahan R, Dutcher S, King K, Petrone AB, Rosofsky R, Shockro LA, Young J, Min JY, Binswanger I, Boudreau D, Griffin MR, Adgent MA, Kuntz J, McMahill-Walraven C, Pawloski PA, Ball R, Toh S. Developing a Standardized and Reusable Method to Link Distributed Health Plan Databases to the National Death Index: Methods Development Study Protocol. JMIR Res Protoc. 2020 Nov 02; 9(11):e21811. PMID: 33136063; PMCID: PMC7669437.
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    7. Kriplani A, Lavery JA, Mishra A, Korenstein D, Lipitz-Snyderman AN, Boudreau DM, Moryl N, Gillespie EF, Salz T. Trends in chronic opioid therapy among survivors of head and neck cancer. Head Neck. 2021 01; 43(1):223-228. PMID: 32964530; PMCID: PMC8405132.
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    8. Cheetham TC, Dublin S, Pocobelli G, Bobb JF, Andrade S, Hechter RC, Portugal C, Munis M, Albertson-Junkans L, Salgado G, Wong L, Maarup TJ, Carroll K, Griffin MR, Raebel MA, Smith D, Li DK, Pawloski PA, Toh S, Taylor L, Hua W, Dinatale M, Ceresa C, Trinidad JP, Boudreau DM. Validity of diagnosis and procedure codes for identifying neural tube defects in infants. Pharmacoepidemiol Drug Saf. 2020 11; 29(11):1489-1493. PMID: 32929845.
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    9. Her Q, Malenfant J, Zhang Z, Vilk Y, Young J, Tabano D, Hamilton J, Johnson R, Raebel M, Boudreau D, Toh S. Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance. JMIR Med Inform. 2020 Jun 04; 8(6):e15073. PMID: 32496200; PMCID: PMC7303834.
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    10. Boudreau DM, Lapham G, Johnson EA, Bobb JF, Matthews AG, McCormack J, Liu D, Campbell CI, Rossom RC, Binswanger IA, Yarborough BJ, Arnsten JH, Cunningham CO, Glass JE, Murphy MT, Zare M, Hechter RC, Ahmedani B, Braciszewski JM, Horigian VE, Szapocznik J, Samet JH, Saxon AJ, Schwartz RP, Bradley KA. Documented opioid use disorder and its treatment in primary care patients across six U.S. health systems. J Subst Abuse Treat. 2020 03; 112S:41-48. PMID: 32220410; PMCID: PMC7107675.
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    11. Gold HT, Shao H, Oratz R, Yu O, Hammer M, Richardson S, Boudreau D. Association of Diabetes and Other Clinical and Sociodemographic Factors With Guideline-concordant Breast Cancer Treatment for Breast Cancer. Am J Clin Oncol. 2020 02; 43(2):101-106. PMID: 31850918; PMCID: PMC7087365.
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    12. D Sullivan M, Boudreau D, Ichikawa L, Cronkite D, Albertson-Junkans L, Salgado G, VonKorff M, Carrell DS. Primary Care Opioid Taper Plans Are Associated with Sustained Opioid Dose Reduction. J Gen Intern Med. 2020 03; 35(3):687-695. PMID: 31907789; PMCID: PMC7080895.
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    13. Lapham G, Boudreau DM, Johnson EA, Bobb JF, Matthews AG, McCormack J, Liu D, Samet JH, Saxon AJ, Campbell CI, Glass JE, Rossom RC, Murphy MT, Binswanger IA, Yarborough BJH, Bradley KA, PROUD Collaborative Investigators. Prevalence and treatment of opioid use disorders among primary care patients in six health systems. Drug Alcohol Depend. 2020 02 01; 207:107732. PMID: 31835068; PMCID: PMC7158756.
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    14. Chen L, Chubak J, Yu O, Pocobelli G, Ziebell RA, Aiello Bowles EJ, Fujii MM, Sterrett AT, Boggs JM, Burnett-Hartman AN, Ritzwoller DP, Hubbard RA, Boudreau DM. Changes in use of opioid therapy after colon cancer diagnosis: a population-based study. Cancer Causes Control. 2019 Dec; 30(12):1341-1350. PMID: 31667710; PMCID: PMC6863090.
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    15. Cook AJ, Wellman RD, Marsh T, Shoaibi A, Tiwari R, Nguyen M, Boudreau D, Weintraub ES, Jackson L, Nelson JC. Applying sequential surveillance methods that use regression adjustment or weighting to control confounding in a multisite, rare-event, distributed setting: Part 2 in-depth example of a reanalysis of the measles-mumps-rubella-varicella combination vaccine and seizure risk. J Clin Epidemiol. 2019 09; 113:114-122. PMID: 31055178.
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    16. Calip GS, Yu O, Boudreau DM, Shao H, Oratz R, Richardson SB, Gold HT. Diabetes and differences in detection of incident invasive breast cancer. Cancer Causes Control. 2019 May; 30(5):435-441. PMID: 30949885.
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    17. Boudreau DM, Chen L, Yu O, Bowles EJA, Chubak J. Risk of second breast cancer events with chronic opioid use in breast cancer survivors. Pharmacoepidemiol Drug Saf. 2019 Apr 03. PMID: 30945381.
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    18. Bowles EJA, Yu O, Ziebell R, Chen L, Boudreau DM, Ritzwoller DP, Hubbard RA, Boggs JM, Burnett-Hartman AN, Sterrett A, Fujii M, Chubak J. Cardiovascular medication use and risks of colon cancer recurrences and additional cancer events: a cohort study. BMC Cancer. 2019 Mar 27; 19(1):270. PMID: 30917783.
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    19. Salz T, Lavery JA, Lipitz-Snyderman AN, Boudreau DM, Moryl N, Gillespie EF, Korenstein D. Trends in Opioid Use Among Older Survivors of Colorectal, Lung, and Breast Cancers. J Clin Oncol. 2019 Apr 20; 37(12):1001-1011. PMID: 30817249.
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    20. Pocobelli G, Yu O, Ziebell RA, Aiello Bowles EJ, Fujii MM, Sterrett AT, Boggs JM, Chen L, Boudreau DM, Ritzwoller DP, Hubbard RA, Chubak J. Use of antidepressants after colon cancer diagnosis and risk of recurrence. Psychooncology. 2019 Apr; 28(4):750-758. PMID: 30703275.
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    21. Chubak J, Yu O, Ziebell RA, Bowles EJA, Sterrett AT, Fujii MM, Boggs JM, Burnett-Hartman AN, Boudreau DM, Chen L, Floyd JS, Ritzwoller DP, Hubbard RA. Risk of colon cancer recurrence in relation to diabetes. Cancer Causes Control. 2018 Nov; 29(11):1093-1103. PMID: 30244297.
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    22. Heath L, Gray SL, Boudreau DM, Thummel K, Edwards KL, Fullerton SM, Crane PK, Larson EB. Cumulative Antidepressant Use and Risk of Dementia in a Prospective Cohort Study. J Am Geriatr Soc. 2018 Oct; 66(10):1948-1955. PMID: 30221747.
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    23. Leonard CE, Brensinger CM, Aquilante CL, Bilker WB, Boudreau DM, Deo R, Flory JH, Gagne JJ, Mangaali MJ, Hennessy S. Comparative Safety of Sulfonylureas and the Risk of Sudden Cardiac Arrest and Ventricular Arrhythmia. Diabetes Care. 2018 04; 41(4):713-722. PMID: 29437823.
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    24. Lott JP, Boudreau DM, Barnhill RL, Weinstock MA, Knopp E, Piepkorn MW, Elder DE, Knezevich SR, Baer A, Tosteson ANA, Elmore JG. Population-Based Analysis of Histologically Confirmed Melanocytic Proliferations Using Natural Language Processing. JAMA Dermatol. 2018 Jan 01; 154(1):24-29. PMID: 29094145.
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    25. Chen L, Chubak J, Boudreau DM, Barlow WE, Weiss NS, Li CI. Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis. Cancer Res. 2017 11 01; 77(21):6033-6041. PMID: 28935814.
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    26. Chen L, Chubak J, Boudreau DM, Barlow WE, Weiss NS, Li CI. Use of Antihypertensive Medications and Risk of Adverse Breast Cancer Outcomes in a SEER-Medicare Population. Cancer Epidemiol Biomarkers Prev. 2017 11; 26(11):1603-1610. PMID: 28807926.
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    27. Drieling RL, LaCroix AZ, Beresford SAA, Boudreau DM, Kooperberg C, Chlebowski RT, Ko MG, Heckbert SR. Long-Term Oral Bisphosphonate Therapy and Fractures in Older Women: The Women's Health Initiative. J Am Geriatr Soc. 2017 Sep; 65(9):1924-1931. PMID: 28555811.
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    28. Boudreau DM, Yu O, Balasubramanian A, Wirtz H, Grauer A, Crittenden DB, Scholes D. A Survey of Women's Awareness of and Reasons for Lack of Postfracture Osteoporotic Care. J Am Geriatr Soc. 2017 Aug; 65(8):1829-1835. PMID: 28422273.
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    29. Wirtz HS, Calip GS, Buist DSM, Gralow JR, Barlow WE, Gray S, Boudreau DM. Evidence for Detection Bias by Medication Use in a Cohort Study of Breast Cancer Survivors. Am J Epidemiol. 2017 04 15; 185(8):661-672. PMID: 28338879.
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    30. Raebel MA, Zeng C, Cheetham TC, Smith DH, Feigelson HS, Carroll NM, Goddard K, Tavel HM, Boudreau DM, Shetterly S, Xu S. Risk of Breast Cancer With Long-Term Use of Calcium Channel Blockers or Angiotensin-Converting Enzyme Inhibitors Among Older Women. Am J Epidemiol. 2017 02 15; 185(4):264-273. PMID: 28186527.
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    31. Babigumira JB, Li M, Boudreau DM, Best JH, Garrison LP. Estimating the Cost of Illness of Giant Cell Arteritis in the United States. Rheumatol Ther. 2017 Jun; 4(1):111-119. PMID: 28084585.
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    32. Veenstra DL, Guzauskas GF, Villa KF, Boudreau DM. The budget impact and cost-effectiveness of defibrotide for treatment of veno-occlusive disease with multi-organ dysfunction in patients post-hematopoietic stem cell transplant. J Med Econ. 2017 May; 20(5):453-463. PMID: 28008770.
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    33. Calip GS, Elmore JG, Boudreau DM. Characteristics associated with nonadherence to medications for hypertension, diabetes, and dyslipidemia among breast cancer survivors. Breast Cancer Res Treat. 2017 01; 161(1):161-172. PMID: 27826756.
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    34. Drieling RL, LaCroix AZ, Beresford SA, Boudreau DM, Kooperberg C, Chlebowski RT, Gass M, Crandall CJ, Womack CR, Heckbert SR. Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative. Menopause. 2016 11; 23(11):1168-1175. PMID: 27433859.
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    35. Reynolds K, Go AS, Leong TK, Boudreau DM, Cassidy-Bushrow AE, Fortmann SP, Goldberg RJ, Gurwitz JH, Magid DJ, Margolis KL, McNeal CJ, Newton KM, Novotny R, Quesenberry CP, Rosamond WD, Smith DH, VanWormer JJ, Vupputuri S, Waring SC, Williams MS, Sidney S. Trends in Incidence of Hospitalized Acute Myocardial Infarction in the Cardiovascular Research Network (CVRN). Am J Med. 2017 Mar; 130(3):317-327. PMID: 27751900.
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    36. Nelson JC, Wellman R, Yu O, Cook AJ, Maro JC, Ouellet-Hellstrom R, Boudreau D, Floyd JS, Heckbert SR, Pinheiro S, Reichman M, Shoaibi A. A Synthesis of Current Surveillance Planning Methods for the Sequential Monitoring of Drug and Vaccine Adverse Effects Using Electronic Health Care Data. EGEMS (Wash DC). 2016; 4(1):1219. PMID: 27713904.
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    37. Hart R, Veenstra DL, Boudreau DM, Roth JA. Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting. Am J Med. 2017 02; 130(2):222-228. PMID: 27593608.
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    38. Drieling RL, LaCroix AZ, Beresford SA, Boudreau DM, Kooperberg C, Heckbert SR. Validity of Self-Reported Medication Use Compared With Pharmacy Records in a Cohort of Older Women: Findings From the Women's Health Initiative. Am J Epidemiol. 2016 08 01; 184(3):233-8. PMID: 27402774.
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    39. Arterburn D, Sofer T, Boudreau DM, Bogart A, Westbrook EO, Theis MK, Simon G, Haneuse S. Long-Term Weight Change after Initiating Second-Generation Antidepressants. J Clin Med. 2016 Apr 13; 5(4). PMID: 27089374.
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    40. Calip GS, Yu O, Elmore JG, Boudreau DM. Comparative safety of diabetes medications and risk of incident invasive breast cancer: a population-based cohort study. Cancer Causes Control. 2016 May; 27(5):709-20. PMID: 27053250.
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    41. Haneuse S, Bogart A, Jazic I, Westbrook EO, Boudreau D, Theis MK, Simon GE, Arterburn D. Learning About Missing Data Mechanisms in Electronic Health Records-based Research: A Survey-based Approach. Epidemiology. 2016 Jan; 27(1):82-90. PMID: 26484425.
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    42. Chubak J, Bowles EJ, Yu O, Buist DS, Fujii M, Boudreau DM. Breast cancer recurrence in relation to antidepressant use. Cancer Causes Control. 2016 Jan; 27(1):125-36. PMID: 26518198.
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    43. Smith DH, Johnson ES, Boudreau DM, Cassidy-Bushrow AE, Fortmann SP, Greenlee RT, Gurwitz JH, Magid DJ, McNeal CJ, Reynolds K, Steinhubl SR, Thorp M, Tom JO, Vupputuri S, VanWormer JJ, Weinstein J, Yang X, Go AS, Sidney S. Comparative Effectiveness of Statin Therapy in Chronic Kidney Disease and Acute Myocardial Infarction: A Retrospective Cohort Study. Am J Med. 2015 Nov; 128(11):1252.e1-1252.e11. PMID: 26169887.
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    44. Hansen RN, Boudreau DM, Ebel BE, Grossman DC, Sullivan SD. Sedative Hypnotic Medication Use and the Risk of Motor Vehicle Crash. Am J Public Health. 2015 Aug; 105(8):e64-9. PMID: 26066943.
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    45. Calip GS, Yu O, Hoskins KF, Boudreau DM. Associations between diabetes medication use and risk of second breast cancer events and mortality. Cancer Causes Control. 2015 Aug; 26(8):1065-77. PMID: 25956271.
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    46. Roth JA, Bradley K, Thummel KE, Veenstra DL, Boudreau D. Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting. Pharmacoepidemiol Drug Saf. 2015 Jun; 24(6):619-27. PMID: 25858232.
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    47. Calip GS, Malone KE, Gralow JR, Stergachis A, Hubbard RA, Boudreau DM. Metabolic syndrome and outcomes following early-stage breast cancer. Breast Cancer Res Treat. 2014 Nov; 148(2):363-77. PMID: 25301086.
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    48. Boudreau DM, Guzauskas GF, Chen E, Lalla D, Tayama D, Fagan SC, Veenstra DL. Cost-effectiveness of recombinant tissue-type plasminogen activator within 3 hours of acute ischemic stroke: current evidence. Stroke. 2014 Oct; 45(10):3032-9. PMID: 25190439.
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    49. Wu JW, Boudreau DM, Park Y, Simonds NI, Freedman AN. Commonly used diabetes and cardiovascular medications and cancer recurrence and cancer-specific mortality: a review of the literature. Expert Opin Drug Saf. 2014 Aug; 13(8):1071-99. PMID: 24999107.
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    50. Calip GS, Hubbard RA, Stergachis A, Malone KE, Gralow JR, Boudreau DM. Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment. Pharmacoepidemiol Drug Saf. 2015 Jan; 24(1):75-85. PMID: 24923811.
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    51. Raebel MA, Newcomer SR, Bayliss EA, Boudreau D, DeBar L, Elliott TE, Ahmed AT, Pawloski PA, Fisher D, Toh S, Donahoo WT. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014 Dec; 23(12):1247-57. PMID: 24733580.
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    52. Boudreau DM, Yu O, Chubak J, Wirtz HS, Bowles EJ, Fujii M, Buist DS. Comparative safety of cardiovascular medication use and breast cancer outcomes among women with early stage breast cancer. Breast Cancer Res Treat. 2014 Apr; 144(2):405-16. PMID: 24557337.
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    53. Roth JA, Boudreau D, Fujii MM, Farin FM, Rettie AE, Thummel KE, Veenstra DL. Genetic risk factors for major bleeding in patients treated with warfarin in a community setting. Clin Pharmacol Ther. 2014 Jun; 95(6):636-43. PMID: 24503627.
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    54. Wirtz HS, Boudreau DM, Gralow JR, Barlow WE, Gray S, Bowles EJ, Buist DS. Factors associated with long-term adherence to annual surveillance mammography among breast cancer survivors. Breast Cancer Res Treat. 2014 Feb; 143(3):541-50. PMID: 24407530.
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    55. Raebel MA, Newcomer SR, Reifler LM, Boudreau D, Elliott TE, DeBar L, Ahmed A, Pawloski PA, Fisher D, Donahoo WT, Bayliss EA. Chronic use of opioid medications before and after bariatric surgery. JAMA. 2013 Oct 02; 310(13):1369-76. PMID: 24084922.
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    56. Chubak J, Boudreau DM, Wirtz HS, McKnight B, Weiss NS. Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival. J Natl Cancer Inst. 2013 Oct 02; 105(19):1456-62. PMID: 23940288.
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    57. Matlock DD, Groeneveld PW, Sidney S, Shetterly S, Goodrich G, Glenn K, Xu S, Yang L, Farmer SA, Reynolds K, Cassidy-Bushrow AE, Lieu T, Boudreau DM, Greenlee RT, Tom J, Vupputuri S, Adams KF, Smith DH, Gunter MJ, Go AS, Magid DJ. Geographic variation in cardiovascular procedure use among Medicare fee-for-service vs Medicare Advantage beneficiaries. JAMA. 2013 Jul 10; 310(2):155-62. PMID: 23839749.
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    58. Wirtz HS, Buist DS, Gralow JR, Barlow WE, Gray S, Chubak J, Yu O, Bowles EJ, Fujii M, Boudreau DM. Frequent antibiotic use and second breast cancer events. Cancer Epidemiol Biomarkers Prev. 2013 Sep; 22(9):1588-99. PMID: 23833124.
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    59. Chubak J, Yu O, Buist DS, Wirtz HS, Boudreau DM. Time scale in follow-up studies: considering disease prognosis. Epidemiology. 2013 Jul; 24(4):628-9. PMID: 23732747.
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    60. Lo Re V, Haynes K, Goldberg D, Forde KA, Carbonari DM, Leidl KB, Hennessy S, Reddy KR, Pawloski PA, Daniel GW, Cheetham TC, Iyer A, Coughlin KO, Toh S, Boudreau DM, Selvam N, Cooper WO, Selvan MS, VanWormer JJ, Avigan MI, Houstoun M, Zornberg GL, Racoosin JA, Shoaibi A. Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database. Pharmacoepidemiol Drug Saf. 2013 Aug; 22(8):861-72. PMID: 23801638.
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    61. Zhou Y, Boudreau DM, Freedman AN. Trends in the use of aspirin and nonsteroidal anti-inflammatory drugs in the general U.S. population. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):43-50. PMID: 23723142.
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    62. Kulldorff M, Dashevsky I, Avery TR, Chan AK, Davis RL, Graham D, Platt R, Andrade SE, Boudreau D, Gunter MJ, Herrinton LJ, Pawloski PA, Raebel MA, Roblin D, Brown JS. Drug safety data mining with a tree-based scan statistic. Pharmacoepidemiol Drug Saf. 2013 May; 22(5):517-23. PMID: 23512870.
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    63. Brown JS, Petronis KR, Bate A, Zhang F, Dashevsky I, Kulldorff M, Avery TR, Davis RL, Chan KA, Andrade SE, Boudreau D, Gunter MJ, Herrinton L, Pawloski PA, Raebel MA, Roblin D, Smith D, Reynolds R. Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic. Pharmaceutics. 2013 Mar 14; 5(1):179-200. PMID: 24300404.
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    64. Boudreau DM, Arterburn D, Bogart A, Haneuse S, Theis MK, Westbrook E, Simon G. Influence of body mass index on the choice of therapy for depression and follow-up care. Obesity (Silver Spring). 2013 Mar; 21(3):E303-13. PMID: 23404891.
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    65. Spangler L, Yu O, Loggers E, Boudreau DM. Bone mineral density screening among women with a history of breast cancer treated with aromatase inhibitors. J Womens Health (Larchmt). 2013 Feb; 22(2):132-40. PMID: 23362883.
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    66. Calip GS, Boudreau DM, Loggers ET. Changes in adherence to statins and subsequent lipid profiles during and following breast cancer treatment. Breast Cancer Res Treat. 2013 Feb; 138(1):225-33. PMID: 23358904.
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    67. Wong WB, Lin VW, Boudreau D, Devine EB. Statins in the prevention of dementia and Alzheimer's disease: a meta-analysis of observational studies and an assessment of confounding. Pharmacoepidemiol Drug Saf. 2013 Apr; 22(4):345-58. PMID: 23225700.
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    68. Boudreau DM, Yu O, Spangler L, Do TP, Fujii M, Ott SM, Critchlow CW, Scholes D. Accuracy of ICD-9 codes to identify nonunion and malunion and developing algorithms to improve case-finding of nonunion and malunion. Bone. 2013 Feb; 52(2):596-601. PMID: 23174214.
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    69. Boudreau DM, Wirtz H, Von Korff M, Catz SL, St John J, Stang PE. A survey of adult awareness and use of medicine containing acetaminophen. Pharmacoepidemiol Drug Saf. 2013 Mar; 22(3):229-40. PMID: 22890688.
      Citations:    
    70. Aiello Bowles EJ, Boudreau DM, Chubak J, Yu O, Fujii M, Chestnut J, Buist DS. Patient-reported discontinuation of endocrine therapy and related adverse effects among women with early-stage breast cancer. J Oncol Pract. 2012 Nov; 8(6):e149-57. PMID: 23598850.
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    71. Cutrona SL, Toh S, Iyer A, Foy S, Daniel GW, Nair VP, Ng D, Butler MG, Boudreau D, Forrow S, Goldberg R, Gore J, McManus D, Racoosin JA, Gurwitz JH. Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel program. Pharmacoepidemiol Drug Saf. 2013 Jan; 22(1):40-54. PMID: 22745038.
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    72. Boudreau DM, Guzauskas G, Villa KF, Fagan SC, Veenstra DL. A model of cost-effectiveness of tissue plasminogen activator in patient subgroups 3 to 4.5 hours after onset of acute ischemic stroke. Ann Emerg Med. 2013 Jan; 61(1):46-55. PMID: 22633340.
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    73. Guzauskas GF, Boudreau DM, Villa KF, Levine SR, Veenstra DL. The cost-effectiveness of primary stroke centers for acute stroke care. Stroke. 2012 Jun; 43(6):1617-23. PMID: 22535277.
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    74. Bowles EJ, Buist DS, Chubak J, Yu O, Johnson J, Chestnut J, Boudreau DM. Endocrine therapy initiation from 2001 to 2008 varies by age at breast cancer diagnosis and tumor size. J Oncol Pract. 2012 Mar; 8(2):113-20. PMID: 23077439.
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    75. Curtis LH, Weiner MG, Boudreau DM, Cooper WO, Daniel GW, Nair VP, Raebel MA, Beaulieu NU, Rosofsky R, Woodworth TS, Brown JS. Design considerations, architecture, and use of the Mini-Sentinel distributed data system. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:23-31. PMID: 22262590.
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    76. Habel LA, Cooper WO, Sox CM, Chan KA, Fireman BH, Arbogast PG, Cheetham TC, Quinn VP, Dublin S, Boudreau DM, Andrade SE, Pawloski PA, Raebel MA, Smith DH, Achacoso N, Uratsu C, Go AS, Sidney S, Nguyen-Huynh MN, Ray WA, Selby JV. ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. JAMA. 2011 Dec 28; 306(24):2673-83. PMID: 22161946.
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    77. Boudreau DM, Yu O, Gray SL, Raebel MA, Johnson J, Larson EB. Concomitant use of cholinesterase inhibitors and anticholinergics: prevalence and outcomes. J Am Geriatr Soc. 2011 Nov; 59(11):2069-76. PMID: 22091958.
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    78. Andrade SE, Moore Simas TA, Boudreau D, Raebel MA, Toh S, Syat B, Dashevsky I, Platt R. Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancy. Pharmacoepidemiol Drug Saf. 2011 Nov; 20(11):1168-76. PMID: 22020902.
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    79. Chubak J, Boudreau DM, Rulyak SJ, Mandelson MT. Colorectal cancer risk in relation to antidepressant medication use. Int J Cancer. 2011 Jan 01; 128(1):227-32. PMID: 20232382.
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    80. Chubak J, Boudreau DM, Fishman PA, Elmore JG. Cost of breast-related care in the year following false positive screening mammograms. Med Care. 2010 Sep; 48(9):815-20. PMID: 20706161.
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    81. Campbell CI, Weisner C, Leresche L, Ray GT, Saunders K, Sullivan MD, Banta-Green CJ, Merrill JO, Silverberg MJ, Boudreau D, Satre DD, Von Korff M. Age and gender trends in long-term opioid analgesic use for noncancer pain. Am J Public Health. 2010 Dec; 100(12):2541-7. PMID: 20724688.
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    82. Boudreau DM, Yu O, Johnson J. Statin use and cancer risk: a comprehensive review. Expert Opin Drug Saf. 2010 Jul; 9(4):603-21. PMID: 20377474.
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    83. Boudreau D, Von Korff M, Rutter CM, Saunders K, Ray GT, Sullivan MD, Campbell CI, Merrill JO, Silverberg MJ, Banta-Green C, Weisner C. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf. 2009 Dec; 18(12):1166-75. PMID: 19718704.
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    84. Malone DC, Boudreau DM, Nichols GA, Raebel MA, Fishman PA, Feldstein AC, Ben-Joseph RH, Okamoto LJ, Boscoe AN, Magid DJ. Association of cardiometabolic risk factors and prevalent cardiovascular events. Metab Syndr Relat Disord. 2009 Dec; 7(6):585-93. PMID: 19900158.
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    85. Boudreau DM, Malone DC, Raebel MA, Fishman PA, Nichols GA, Feldstein AC, Boscoe AN, Ben-Joseph RH, Magid DJ, Okamoto LJ. Health care utilization and costs by metabolic syndrome risk factors. Metab Syndr Relat Disord. 2009 Aug; 7(4):305-14. PMID: 19558267.
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    86. Weisner CM, Campbell CI, Ray GT, Saunders K, Merrill JO, Banta-Green C, Sullivan MD, Silverberg MJ, Mertens JR, Boudreau D, Von Korff M. Trends in prescribed opioid therapy for non-cancer pain for individuals with prior substance use disorders. Pain. 2009 Oct; 145(3):287-93. PMID: 19581051.
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    87. Mazor KM, Sabin JE, Goff SL, Smith DH, Rolnick S, Roblin D, Raebel MA, Herrinton LJ, Gurwitz JH, Boudreau D, Meterko V, Dodd KS, Platt R. Cluster randomized trials to study the comparative effectiveness of therapeutics: stakeholders' concerns and recommendations. Pharmacoepidemiol Drug Saf. 2009 Jul; 18(7):554-61. PMID: 19402030.
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    88. Chubak J, Boudreau DM, Rulyak SJ, Mandelson MT. Colorectal cancer risk in relation to use of acid suppressive medications. Pharmacoepidemiol Drug Saf. 2009 Jul; 18(7):540-4. PMID: 19367565.
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    89. Banta-Green CJ, Merrill JO, Doyle SR, Boudreau DM, Calsyn DA. Opioid use behaviors, mental health and pain--development of a typology of chronic pain patients. Drug Alcohol Depend. 2009 Sep 01; 104(1-2):34-42. PMID: 19473786.
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    90. Banta-Green CJ, Merrill JO, Doyle SR, Boudreau DM, Calsyn DA. Measurement of opioid problems among chronic pain patients in a general medical population. Drug Alcohol Depend. 2009 Sep 01; 104(1-2):43-9. PMID: 19473787.
      Citations:    
    91. Ogale SS, Lee TA, Au DH, Boudreau DM, Sullivan SD. Cardiovascular events associated with ipratropium bromide in COPD. Chest. 2010 Jan; 137(1):13-9. PMID: 19363211.
      Citations:    
    92. Brown JS, Kulldorff M, Petronis KR, Reynolds R, Chan KA, Davis RL, Graham D, Andrade SE, Raebel MA, Herrinton L, Roblin D, Boudreau D, Smith D, Gurwitz JH, Gunter MJ, Platt R. Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations. Pharmacoepidemiol Drug Saf. 2009 Mar; 18(3):226-34. PMID: 19148879.
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    93. Andrade SE, McPhillips H, Loren D, Raebel MA, Lane K, Livingston J, Boudreau DM, Smith DH, Davis RL, Willy ME, Platt R. Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn. Pharmacoepidemiol Drug Saf. 2009 Mar; 18(3):246-52. PMID: 19148882.
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    94. Yu O, Boudreau DM, Buist DS, Miglioretti DL. Statin use and female reproductive organ cancer risk in a large population-based setting. Cancer Causes Control. 2009 Jul; 20(5):609-16. PMID: 19043788.
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    95. Boudreau DM, Koehler E, Rulyak SJ, Haneuse S, Harrison R, Mandelson MT. Cardiovascular medication use and risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3076-80. PMID: 18957524.
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    96. Von Korff M, Korff MV, Saunders K, Thomas Ray G, Boudreau D, Campbell C, Merrill J, Sullivan MD, Rutter CM, Silverberg MJ, Banta-Green C, Weisner C. De facto long-term opioid therapy for noncancer pain. Clin J Pain. 2008 Jul-Aug; 24(6):521-7. PMID: 18574361.
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    97. Bonomi AE, Boudreau DM, Fishman PA, Ludman E, Mohelnitzky A, Cannon EA, Seger D. Quality of life valuations of mammography screening. Qual Life Res. 2008 Jun; 17(5):801-14. PMID: 18491217.
      Citations:    
    98. Boudreau DM, Yu O, Buist DS, Miglioretti DL. Statin use and prostate cancer risk in a large population-based setting. Cancer Causes Control. 2008 Sep; 19(7):767-74. PMID: 18322813.
      Citations:    
    99. Goff SL, Feld A, Andrade SE, Mahoney L, Beaton SJ, Boudreau DM, Davis RL, Goodman M, Hartsfield CL, Platt R, Roblin D, Smith D, Yood MU, Dodd K, Gurwitz JH. Administrative data used to identify patients with irritable bowel syndrome. J Clin Epidemiol. 2008 Jun; 61(6):617-21. PMID: 18471667.
      Citations:    
    100. Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, Rolnick SJ, Roblin D, Smith DH, Dal Pan GJ, Scott PE, Platt R. Outpatient use of cardiovascular drugs during pregnancy. Pharmacoepidemiol Drug Saf. 2008 Mar; 17(3):240-7. PMID: 18200619.
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    101. Chubak J, Buist DS, Boudreau DM, Rossing MA, Lumley T, Weiss NS. Breast cancer recurrence risk in relation to antidepressant use after diagnosis. Breast Cancer Res Treat. 2008 Nov; 112(1):123-32. PMID: 18058227.
      Citations:    
    102. Brown JS, Kulldorff M, Chan KA, Davis RL, Graham D, Pettus PT, Andrade SE, Raebel MA, Herrinton L, Roblin D, Boudreau D, Smith D, Gurwitz JH, Gunter MJ, Platt R. Early detection of adverse drug events within population-based health networks: application of sequential testing methods. Pharmacoepidemiol Drug Saf. 2007 Dec; 16(12):1275-84. PMID: 17955500.
      Citations:    
    103. Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, Rolnick SJ, Roblin D, Smith DH, Willy ME, Staffa JA, Platt R. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol. 2008 Feb; 198(2):194.e1-5. PMID: 17905176.
      Citations:    
    104. Mazor KM, Sabin JE, Boudreau D, Goodman MJ, Gurwitz JH, Herrinton LJ, Raebel MA, Roblin D, Smith DH, Meterko V, Platt R. Cluster randomized trials: opportunities and barriers identified by leaders of eight health plans. Med Care. 2007 Oct; 45(10 Supl 2):S29-37. PMID: 17909379.
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    105. Boudreau DM, Luce CL, Ludman E, Bonomi AE, Fishman PA. Concordance of population-based estimates of mammography screening. Prev Med. 2007 Oct; 45(4):262-6. PMID: 17698182.
      Citations:    
    106. Boudreau DM, Yu O, Miglioretti DL, Buist DS, Heckbert SR, Daling JR. Statin use and breast cancer risk in a large population-based setting. Cancer Epidemiol Biomarkers Prev. 2007 Mar; 16(3):416-21. PMID: 17372235.
      Citations:    
    107. Boudreau DM, Rutter CM, Buist DS. The influence of statin use on breast density. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):1026-9. PMID: 16702387.
      Citations:    
    108. Boudreau DM, Buist DS, Rutter CM, Fishman PA, Beverly KR, Taplin S. Impact of hormone therapy on false-positive recall and costs among women undergoing screening mammography. Med Care. 2006 Jan; 44(1):62-9. PMID: 16365614.
      Citations:    
    109. Chien C, Li CI, Heckbert SR, Malone KE, Boudreau DM, Daling JR. Antidepressant use and breast cancer risk. Breast Cancer Res Treat. 2006 Jan; 95(2):131-40. PMID: 16322894.
      Citations:    
    110. Boudreau DM, Doescher MP, Saver BG, Jackson JE, Fishman PA. Reliability of Group Health Cooperative automated pharmacy data by drug benefit status. Pharmacoepidemiol Drug Saf. 2005 Dec; 14(12):877-84. PMID: 15931653.
      Citations:    
    111. Bonomi AE, Boudreau DM, Fishman PA, Meenan RT, Revicki DA. Is a family equal to the sum of its parts? Estimating family-level well-being for cost-effectiveness analysis. Qual Life Res. 2005 May; 14(4):1127-33. PMID: 16041907.
      Citations:    
    112. Voigt LF, Boudreau DM, Weiss NS, Malone KE, Li CI, Daling JR. Re: "studies with low response proportions may be less biased than studies with high response proportions". Am J Epidemiol. 2005 Feb 15; 161(4):401-2; author reply 402-3. PMID: 15692084.
      Citations:    
    113. Greene SM, Larson EB, Boudreau DM, Johnson KE, Ralston J, Reid R, Fishman P. The coordinated clinical studies network: a multidisciplinary alliance to facilitate research and improve care. Perm J. 2005; 9(4):33-5. PMID: 22811643.
      Citations:    
    114. Boudreau DM, Gardner JS, Malone KE, Heckbert SR, Blough DK, Daling JR. The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study. Cancer. 2004 Jun 01; 100(11):2308-16. PMID: 15160333.
      Citations:    
    115. Boudreau DM, Doescher MP, Jackson JE, Fishman PA, Saver BG. Impact of healthcare delivery system on where HMO-enrolled seniors purchase medications. Ann Pharmacother. 2004 Jul-Aug; 38(7-8):1317-8. PMID: 15150379.
      Citations:    
    116. Capoccia KL, Boudreau DM, Blough DK, Ellsworth AJ, Clark DR, Stevens NG, Katon WJ, Sullivan SD. Randomized trial of pharmacist interventions to improve depression care and outcomes in primary care. Am J Health Syst Pharm. 2004 Feb 15; 61(4):364-72. PMID: 15011764.
      Citations:    
    117. Boudreau DM, Daling JR, Malone KE, Gardner JS, Blough DK, Heckbert SR. A validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use among older women. Am J Epidemiol. 2004 Feb 01; 159(3):308-17. PMID: 14742292.
      Citations:    
    118. Li CI, Malone KE, Weiss NS, Boudreau DM, Cushing-Haugen KL, Daling JR. Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65-79 years. Cancer. 2003 Oct 01; 98(7):1504-13. PMID: 14508839.
      Citations:    
    119. Boudreau DM, Leveille SG, Gray SL, Black DJ, Guralnik JM, Ferrucci L, LaCroix AZ. Risks for frequent antimicrobial-treated infections in postmenopausal women. Aging Clin Exp Res. 2003 Feb; 15(1):12-8. PMID: 12841413.
      Citations:    
    120. Boudreau DM, Capoccia KL, Sullivan SD, Blough DK, Ellsworth AJ, Clark DL, Katon WJ, Walker EA, Stevens NG. Collaborative care model to improve outcomes in major depression. Ann Pharmacother. 2002 Apr; 36(4):585-91. PMID: 11918503.
      Citations:    
    121. Chaiyakunapruk N, Boudreau D, Ramsey SD. Pharmaco-economic impact of HMG-CoA reductase inhibitors in type 2 diabetes. J Cardiovasc Risk. 2001 Jun; 8(3):127-32. PMID: 11455843.
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